KEGG   DRUG: D00483Help
Entry
D00483                      Drug                                   

Name
Propranolol hydrochloride (JP16/USP);
Inderal (TN);
Innopran XL (TN)
Product
  Generic
PROPRANOLOL (General Injectables & Vaccines), PROPRANOLOL (Physicians Total Care), PROPRANOLOL HYDROCHLORIDE (Physicians Total Care), PROPRANOLOL (West-ward Pharmaceutical Corp), PROPRANOLOL HYDROCHLORIDE (A-S Medication Solutions LLC), PROPRANOLOL (APP Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Actavis Elizabeth LLC), PROPRANOLOL HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), PROPRANOLOL HYDROCHLORIDE (American Health Packaging), PROPRANOLOL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), PROPRANOLOL HYDROCHLORIDE (Breckenridge Pharmaceutical), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Cadila Healthcare Limited), PROPRANOLOL HYDROCHLORIDE (Cardinal Health), PROPRANOLOL HYDROCHLORIDE (Cardinal Health), PROPRANOLOL HYDROCHLORIDE (Cardinal Health), PROPRANOLOL HYDROCHLORIDE (Carilion Materials Management), PROPRANOLOL HYDROCHLORIDE (Carilion Materials Management), PROPRANOLOL HYDROCHLORIDE (Clinical Solutions Wholesale), PROPRANOLOL HYDROCHLORIDE (Dispensing Solutions), PROPRANOLOL HYDROCHLORIDE (General Injectables & Vaccines), PROPRANOLOL HYDROCHLORIDE (Golden State Medical Supply), PROPRANOLOL HYDROCHLORIDE (Heritage Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), PROPRANOLOL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), PROPRANOLOL HYDROCHLORIDE (Major Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Mylan Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Mylan Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (NCS HealthCare of KY), PROPRANOLOL HYDROCHLORIDE (NCS HealthCare of KY), PROPRANOLOL HYDROCHLORIDE (Northstar RxLLC), PROPRANOLOL HYROCHLORIDE (Northwind Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (PD-Rx Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (PD-Rx Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Physicians Total Care), PROPRANOLOL HYDROCHLORIDE (Physicians Total Care), PROPRANOLOL HYDROCHLORIDE (Pliva), PROPRANOLOL HYDROCHLORIDE (Preferred Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Qualitest Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (Rebel Distributors Corp), PROPRANOLOL HYDROCHLORIDE (Rebel Distributors Corp.), PROPRANOLOL HYDROCHLORIDE (Rouses Point Pharm), PROPRANOLOL HYDROCHLORIDE (Roxane Laboratories), PROPRANOLOL (STAT RX USA LLC), PROPRANOLOL HYDROCHLORIDE (Sandoz), PROPRANOLOL HYDROCHLORIDE (State of Florida DOH Central Pharmacy), PROPRANOLOL HYDROCHLORIDE (State of Florida DOH Central Pharmacy), PROPRANOLOL HYDROCHLORIDE (State of Florida DOH Central Pharmacy), PROPRANOLOL HYDROCHLORIDE (State of Florida DOH Central Pharmacy), PROPRANOLOL HYDROCHLORIDE (State of Florida DOH Central Pharmacy), PROPRANOLOL HYDROCHLORIDE (TYA Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (UDL Laboratories), PROPRANOLOL HYDROCHLORIDE (Unit Dose Services), PROPRANOLOL HYDROCHLORIDE (Unit Dose Services), PROPRANOLOL HYDROCHLORIDE (Unit Dose Services), PROPRANOLOL HYDROCHLORIDE (Unit Dose Services), PROPRANOLOL HYDROCHLORIDE (Upsher-Smith Laboratories), PROPRANOLOL HYDROCHLORIDE (Watson Laboratories), PROPRANOLOL HYDROCHLORIDE (Zydus Pharmaceuticals (USA))
Formula
C16H21NO2. HCl
Exact mass
295.1339
Mol weight
295.8044
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-adrenergic [beta-receptor];
Cardiac depressant [anti-arrhythmic]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Class II antiarrhythmic agent
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor antagonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor antagonist [HSA:155] [KO:K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04970  Salivary secretion  
 
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2C19 [HSA:1557], CYP2D6 [HSA:1565], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP1A2 [HSA:1544]
Drug interaction
Structure map
Antiarrhythmic drugs
Antimigraines
Naphthalene family
beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AA Beta blocking agents, non-selective
     C07AA05 Propranolol
      D00483  Propranolol hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Propranolol
    D00483  Propranolol hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2123  Beta blockers
     D00483  Propranolol hydrochloride (JP16/USP)
   214  Antihypertensives
    2149  Others
     D00483  Propranolol hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Propranolol
      D00483  Propranolol hydrochloride (JP16/USP)
    beta2-adrenergic receptor
     Propranolol
      D00483  Propranolol hydrochloride (JP16/USP)
    beta3-adrenergic receptor
     Propranolol
      D00483  Propranolol hydrochloride (JP16/USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Propranolol
    D00483  Propranolol hydrochloride (JP16/USP)
  CYP2C19
   Propranolol
    D00483  Propranolol hydrochloride (JP16/USP)
  CYP2D6
   Propranolol
    D00483  Propranolol hydrochloride (JP16/USP)
  CYP3A4
   Propranolol
    D00483  Propranolol hydrochloride (JP16/USP)
   Propranolol
    D00483  Propranolol hydrochloride (JP16/USP)
  CYP3A5
   Propranolol
    D00483  Propranolol hydrochloride (JP16/USP)
  CYP3A7
   Propranolol
    D00483  Propranolol hydrochloride (JP16/USP)
 Inhbitors
  CYP1A2
   Propranolol
    D00483  Propranolol hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00483  Propranolol hydrochloride
  D00483  Propranolol hydrochloride tablets
BRITE hierarchy
Other DBs
CAS: 
318-98-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        20
            1   C8x C     7.6300  -12.9500
            2   C8x C     7.6300  -14.3500
            3   C8x C     8.8424  -15.0500
            4   C8y C    10.0549  -14.3500
            5   C8y C    10.0549  -12.9500
            6   C8x C     8.8424  -12.2500
            7   C8x C    11.2673  -15.0500
            8   C8x C    12.4797  -14.3500
            9   C8x C    12.4797  -12.9500
            10  C8y C    11.2673  -12.2500
            11  O2a O    11.2673  -10.8500
            12  C1b C    12.4818  -10.1488
            13  C1c C    13.6783  -10.8398
            14  C1b C    14.8651  -10.1546
            15  O1a O    13.6784  -12.2497
            16  N1b N    16.0566  -10.8428
            17  C1c C    17.2460  -10.1561
            18  C1a C    18.4362  -10.8435
            19  C1a C    17.2462   -8.7502
            20  X   Cl   18.7600  -14.2800
BOND        20
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12   10  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   13  15 1
            17   14  16 1
            18   16  17 1
            19   17  18 1
            20   17  19 1

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