KEGG   DRUG: D00503Help
Entry
D00503                      Drug                                   

Name
Perphenazine (JP16/USP/INN);
Trilafon (TN)
Product
  Generic
Formula
C21H26ClN3OS
Exact mass
403.1485
Mol weight
403.9686
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antipsychotic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Phenothiazine derivatives
Target
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Phenothiazines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AB Phenothiazines with piperazine structure
     N05AB03 Perphenazine
      D00503  Perphenazine (JP16/USP/INN)
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Perphenazine
    D00503  Perphenazine (JP16/USP/INN)
 Antipsychotics
  1st Generation/Typical
   Perphenazine
    D00503  Perphenazine (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1172  Phenothiazines
     D00503  Perphenazine (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor
     Perphenazine
      D00503  Perphenazine (JP16/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Perphenazine
    D00503  Perphenazine (JP16/USP/INN)
 Inhbitors
  CYP2D6
   Perphenazine
    D00503  Perphenazine (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00503  Perphenazine
  D00503  Perphenazine tablets
BRITE hierarchy
Other DBs
CAS: 
58-39-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        27
            1   C8x C    16.1000  -11.4100
            2   C8x C    16.1000  -12.8100
            3   C8x C    17.3124  -13.5100
            4   C8y C    18.5249  -12.8100
            5   C8y C    18.5249  -11.4100
            6   C8x C    17.3124  -10.7100
            7   S2x S    19.7373  -13.5100
            8   C8y C    20.9497  -12.8100
            9   C8y C    20.9497  -11.4100
            10  N4y N    19.7373  -10.7100
            11  C8x C    22.1622  -13.5100
            12  C8x C    23.3746  -12.8100
            13  C8y C    23.3746  -11.4100
            14  C8x C    22.1622  -10.7100
            15  C1b C    19.7373   -9.3100
            16  C1b C    20.9518   -8.6088
            17  C1b C    22.1483   -9.2998
            18  N1y N    23.3351   -8.6146
            19  C1x C    24.5266   -9.3028
            20  C1x C    25.7391   -8.6029
            21  N1y N    25.7393   -7.2029
            22  C1x C    24.5478   -6.5148
            23  C1x C    23.3353   -7.2146
            24  C1b C    26.9641   -6.4958
            25  C1b C    28.1720   -7.1932
            26  O1a O    29.3532   -6.5113
            27  X   Cl   24.5911  -10.7077
BOND        30
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    8  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16    9  14 2
            17   10  15 1
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   18  23 1
            27   21  24 1
            28   24  25 1
            29   25  26 1
            30   13  27 1

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