KEGG   DRUG: D00584Help
Entry
D00584                      Drug                                   

Name
Fluorouracil (JP16/USP/INN);
5-FU (TN);
Adrucil (TN);
Carac (TN);
Fluoroplex (TN)
Product
  Generic
FLUOROURACIL (Accord Healthcare), FLUOROURACIL (Accord Healthcare), FLUOROURACIL (Fresenius Kabi USA), FLUOROURACIL (Fresenius Kabi USA), FLUOROURACIL (Fresenius Kabi USA), FLUOROURACIL (Fresenius Kabi USA), FLUOROURACIL (Fresenius Kabi USA), FLUOROURACIL (Fresenius Kabi USA), FLUOROURACIL (GeneraMedix), FLUOROURACIL (Pfizer Laboratories Div Pfizer), FLUOROURACIL (Pfizer Laboratories Div Pfizer), FLUOROURACIL (Physicians Total Care), FLUOROURACIL (Rebel Distributors Corp), FLUOROURACIL (Sandoz), FLUOROURACIL (Sandoz), FLUOROURACIL (Spear Dermatology Products), FLUOROURACIL (Spear Dermatology Products), FLUOROURACIL (Taro Pharmaceutical Industries), FLUOROURACIL (Taro Pharmaceuticals U.S.A.), FLUOROURACIL (Taro Pharmaceuticals U.S.A.), ADRUCIL (Teva Parenteral Medicines), ADRUCIL (Teva Parenteral Medicines)
Formula
C4H3FN2O2
Exact mass
130.0179
Mol weight
130.0772
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Target
thymidylate synthase inhibitor [HSA:7298] [KO:K00560]
  Pathway
hsa00240  Pyrimidine metabolism
hsa00670  One carbon pool by folate  
 
Metabolism
Enzyme: DPYD [HSA:1806]
Interaction
Genomic biomarker: DPYD [HSA:1806]
Drug interaction
Structure map
Antineoplastics - antimetabolic agents
Other map
Drug metabolism - other enzymes
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01B ANTIMETABOLITES
    L01BC Pyrimidine analogues
     L01BC02 Fluorouracil
      D00584  Fluorouracil (JP16/USP/INN)
USP drug classification [BR:br08302]
 Dermatological Agents
  Fluorouracil
   D00584  Fluorouracil (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   422  Antimetabolites
    4223  Fluorouracils
     D00584  Fluorouracil (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases
   thymidylate synthase
    Fluorouracil
     D00584  Fluorouracil (JP16/USP/INN)
Antineoplastics [BR:br08308]
 Antimetabolites
  Pyrimidine analogs
   Fluorouracil
    D00584  Fluorouracil (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00584  Fluorouracil
BRITE hierarchy
Other DBs
CAS: 
51-21-8
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        9
            1   C8y C    20.7957  -18.3013
            2   C8y C    19.5791  -19.0057
            3   N4x N    22.0068  -19.0057
            4   O5x O    20.7843  -16.8981
            5   C8x C    19.5791  -20.4030
            6   X   F    18.3622  -18.3013
            7   C8y C    22.0068  -20.4030
            8   N4x N    20.7957  -21.1017
            9   O5x O    23.2061  -21.1017
BOND        9
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     5   8 1
            8     7   9 2
            9     7   8 1

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