KEGG   DRUG: D00592Help
Entry
D00592                      Drug                                   

Name
Diaphenylsulfone (JAN);
Dapsone (USP);
Aczone (TN)
Product
  Generic
Formula
C12H12N2O2S
Exact mass
248.0619
Mol weight
248.3009
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial [leprostatic];
Suppressant [dermatitis herpetiformis] [DS:H00344]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency [DS:H00668] are more prone to hemolysis with the use of Dapsone.
Target
dihydropteroate synthase inhibitor [KO:K00796]
  Pathway
ko00790  Folate biosynthesis  
 
Metabolism
Enzyme: CYP2E1 [HSA:1571], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: G6PD [HSA:2539]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AX Other anti-acne preparations for topical use
     D10AX05 Dapsone
      D00592  Diaphenylsulfone (JAN); Dapsone (USP)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J04 ANTIMYCOBACTERIALS
   J04B DRUGS FOR TREATMENT OF LEPRA
    J04BA Drugs for treatment of lepra
     J04BA02 Dapsone
      D00592  Diaphenylsulfone (JAN); Dapsone (USP)
USP drug classification [BR:br08302]
 Antimycobacterials
  Antimycobacterials, Other
   Dapsone
    D00592  Diaphenylsulfone (JAN); Dapsone (USP)
 Dermatological Agents
  Dapsone
   D00592  Diaphenylsulfone (JAN); Dapsone (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   269  Miscellaneous
    2699  Others
     D00592  Diaphenylsulfone (JAN); Dapsone (USP)
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   623  Leprostatics
    6231  Sulfones
     D00592  Diaphenylsulfone (JAN); Dapsone (USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Folic acid biosynthesis inhibitor
   dihydropteroate synthase inhibitor
    Others
     Dapsone
      D00592  Diaphenylsulfone (JAN); Dapsone (USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Diaphenylsulfone
    D00592  Diaphenylsulfone (JAN); Dapsone (USP)
BRITE hierarchy
Other DBs
CAS: 
80-08-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        17
            1   S4a S    21.9800  -14.6136
            2   C8y C    23.1922  -15.3246
            3   C8y C    20.7736  -15.3187
            4   O3c O    20.9776  -13.6228
            5   O3c O    22.9708  -13.6228
            6   C8x C    24.4045  -14.6195
            7   C8x C    23.1922  -16.7234
            8   C8x C    19.5614  -14.6136
            9   C8x C    20.7736  -16.7175
            10  C8x C    25.6050  -15.3187
            11  C8x C    24.4045  -17.4168
            12  C8x C    18.3433  -15.3187
            13  C8x C    19.5614  -17.4168
            14  C8y C    25.6167  -16.7234
            15  C8y C    18.3433  -16.7175
            16  N1a N    26.8174  -17.4285
            17  N1a N    17.1369  -17.4168
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     1   5 2
            5     2   6 2
            6     2   7 1
            7     3   8 2
            8     3   9 1
            9     6  10 1
            10    7  11 2
            11    8  12 1
            12    9  13 2
            13   10  14 2
            14   12  15 2
            15   14  16 1
            16   15  17 1
            17   11  14 1
            18   13  15 1

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