KEGG   DRUG: D00601Help
Entry
D00601                      Drug                                   

Name
Metoprolol tartrate (JP16/USP);
Lopressor (TN)
Product
  Generic
METOPROLOL TARTATE (Northwind Pharmaceuticals), METOPROLOL TARTRATE (Aidarex Pharmaceuticals LLC), METOPROLOL TARTRATE (Alembic Pharmaceuticals Limited), METOPROLOL TARTRATE (American Health Packaging), METOPROLOL TARTRATE (American Regent), METOPROLOL TARTRATE (Aphena Pharma Solutions - Tennessee), METOPROLOL TARTRATE (Aphena Pharma Solutions - Tennessee), METOPROLOL TARTRATE (Aurobindo Pharma Limited), METOPROLOL TARTRATE (Aurolife Pharma LLC), METOPROLOL TARTRATE (Bedford Laboratories), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Caraco Pharmaceutical Laboratories), METOPROLOL TARTRATE (Caraco Pharmaceutical Laboratories), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL (Claris Lifesciences), METOPROLOL TARTRATE (Clinical Solutions Wholesale), METOPROLOL TARTRATE (Contract Pharmacy Services-PA), METOPROLOL TARTRATE (Contract Pharmacy Services-PA), METOPROLOL TARTRATE (Cronus Pharma LLC), METOPROLOL TARTRATE (DIRECT RX), METOPROLOL TARTRATE (Dispensing Solutions), METOPROLOL (Fresenius Kabi USA), METOPROLOL TARTRATE (Gen-Source Rx), METOPROLOL TARTRATE (General Injectables & Vaccines), METOPROLOL TARTRATE (Greenstone LLC), METOPROLOL TARTRATE (Hospira), METOPROLOL TARTRATE (Hospira), METOPROLOL TARTRATE (Ingenus Pharmaceuticals), METOPROLOL TARTRATE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), METOPROLOL TARTRATE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), METOPROLOL TARTRATE (Lake Erie Medical DBA Quality Care Products LLC), METOPROLOL TARTRATE (Lake Erie Medical DBA Quality Care Products LLC), METOPROLOL TARTRATE (Lake Erie Medical DBA Quality Care Products LLC), METOPROLOL TARTRATE (Legacy Pharmaceutical Packaging), METOPROLOL TARTRATE (Major Pharmaceuticals), METOPROLOL TARTRATE (Major Pharmaceuticals), METOPROLOL TARTRATE (Major Pharmaceuticals), METOPROLOL TARTRATE (McKesson Contract Packaging), METOPROLOL TARTRATE (McKesson Contract Packaging), METOPROLOL TARTRATE (Med-Health Pharma), METOPROLOL TARTRATE (MedVantx), METOPROLOL TARTRATE (Mylan Institutional), METOPROLOL TARTRATE (Mylan Pharmaceuticals), METOPROLOL TARTRATE (Mylan Pharmaceuticals), METOPROLOL TARTRATE (NCS HealthCare of KY), METOPROLOL TARTRATE (NCS HealthCare of KY), METOPROLOL TARTRATE (New Horizon Rx Group), METOPROLOL TARTRATE (PD-Rx Pharmaceuticals), METOPROLOL TARTRATE (PD-Rx Pharmaceuticals), METOPROLOL TARTRATE (PD-Rx Pharmaceuticals), METOPROLOL TARTRATE (PD-Rx Pharmaceuticals), METOPROLOL TARTRATE (PD-Rx Pharmaceuticals), METOPROLOL TARTRATE (Physicians Total Care), METOPROLOL TARTRATE (Physicians Total Care), METOPROLOL TARTRATE (Preferred Pharmaceuticals), METOPROLOL TARTRATE (Preferred Pharmaceuticals), METOPROLOL TARTRATE (Proficient Rx LP), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (Ranbaxy Pharmaceuticals), METOPROLOL TARTRATE (Rebel Distributors Corp.), METOPROLOL TARTRATE (STAT RX USA LLC), METOPROLOL (Sagent Pharmaceuticals), METOPROLOL TARTRATE (Sandoz), METOPROLOL TARTRATE (Sandoz), METOPROLOL TARTRATE (St Marys Medical Park Pharmacy), METOPROLOL TARTRATE (St Marys Medical Park Pharmacy), METOPROLOL TARTRATE (State of Florida DOH Central Pharmacy), METOPROLOL TARTRATE (State of Florida DOH Central Pharmacy), METOPROLOL TARTRATE (Teva Pharmaceuticals USA), METOPROLOL TARTRATE (Unit Dose Services), METOPROLOL TARTRATE (Unit Dose Services), METOPROLOL TARTRATE (Unit Dose Services), METOPROLOL TARTRATE (Watson Laboratories), METOPROLOL TARTRATE (West-ward Pharmaceutical Corp)
Formula
(C15H25NO3)2. C4H6O6
Exact mass
684.3833
Mol weight
684.8146
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-adrenergic [beta-receptor]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04970  Salivary secretion  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antiarrhythmic drugs
Antimigraines
beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AB Beta blocking agents, selective
     C07AB02 Metoprolol
      D00601  Metoprolol tartrate (JP16/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Metoprolol
    D00601  Metoprolol tartrate (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2123  Beta blockers
     D00601  Metoprolol tartrate (JP16/USP)
   214  Antihypertensives
    2149  Others
     D00601  Metoprolol tartrate (JP16/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Metoprolol
      D00601  Metoprolol tartrate (JP16/USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Metoprolol
    D00601  Metoprolol tartrate (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00601  Metoprolol tartrate
  D00601  Metoprolol tartrate tablets
BRITE hierarchy
Other DBs
CAS: 
56392-17-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        48
            1   C8y C    31.6068  -15.3787
            2   C8x C    30.4184  -16.0777
            3   C8x C    31.6068  -13.9806
            4   O2a O    32.7952  -16.0777
            5   C8x C    29.1601  -15.3787
            6   C8x C    30.4184  -13.2817
            7   C1b C    34.0534  -15.3787
            8   C8y C    29.1601  -13.9806
            9   C1c C    35.2418  -16.0777
            10  C1b C    27.9718  -13.2817
            11  C1b C    36.4302  -15.3787
            12  O1a O    35.2418  -17.4758
            13  C1b C    26.7833  -13.9806
            14  N1b N    37.6884  -16.0777
            15  O2a O    25.5251  -13.2817
            16  C1c C    38.8768  -15.3787
            17  C1a C    24.2669  -14.0505
            18  C1a C    40.0652  -16.0777
            19  C1a C    38.8768  -14.0505
            20  C1c C    37.3800  -21.1400
            21  C1c C    38.6400  -20.4400
            22  C6a C    36.1900  -20.4400
            23  O1a O    37.3800  -22.5400
            24  C6a C    39.8300  -21.1400
            25  O1a O    38.6400  -19.0400
            26  O6a O    35.0000  -21.1400
            27  O6a O    36.1900  -19.0400
            28  O6a O    41.0200  -20.4400
            29  O6a O    39.8300  -22.5400
            30  C8y C    31.6068  -15.3787
            31  C8x C    30.4184  -16.0777
            32  C8x C    29.1601  -15.3787
            33  C8y C    29.1601  -13.9806
            34  C1b C    27.9718  -13.2817
            35  C1b C    26.7833  -13.9806
            36  O2a O    25.5251  -13.2817
            37  C1a C    24.2669  -14.0505
            38  C8x C    30.4184  -13.2817
            39  C8x C    31.6068  -13.9806
            40  O2a O    32.7952  -16.0777
            41  C1b C    34.0534  -15.3787
            42  C1c C    35.2418  -16.0777
            43  C1b C    36.4302  -15.3787
            44  N1b N    37.6884  -16.0777
            45  C1c C    38.8768  -15.3787
            46  C1a C    40.0652  -16.0777
            47  C1a C    38.8768  -14.0505
            48  O1a O    35.2418  -17.4758
BOND        47
            1    20  21 1
            2    20  22 1
            3    20  23 1 #Up
            4    21  24 1
            5    21  25 1 #Up
            6    22  26 1
            7    22  27 2
            8    24  28 1
            9    24  29 2
            10    1   2 2
            11    1   3 1
            12    1   4 1
            13    2   5 1
            14    3   6 2
            15    4   7 1
            16    5   8 2
            17    7   9 1
            18    8  10 1
            19    9  11 1
            20    9  12 1
            21   10  13 1
            22   11  14 1
            23   13  15 1
            24   14  16 1
            25   15  17 1
            26   16  18 1
            27   16  19 1
            28    6   8 1
            29   30  31 2
            30   30  39 1
            31   30  40 1
            32   31  32 1
            33   39  38 2
            34   40  41 1
            35   32  33 2
            36   41  42 1
            37   33  34 1
            38   42  43 1
            39   42  48 1
            40   34  35 1
            41   43  44 1
            42   35  36 1
            43   44  45 1
            44   36  37 1
            45   45  46 1
            46   45  47 1
            47   38  33 1
BRACKET     1    22.1900  -18.0600   22.1900  -12.1800
            1    41.5800  -12.1800   41.5800  -18.0600
            1  2
 ORIGINAL  1    1   2   5   8  10  13  15  17   6   3   4   7   9  11  14  16
            1   18  19  12
 REPEAT    1   30  31  32  33  34  35  36  37  38  39  40  41  42  43  44  45
            1   46  47  48

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