KEGG   DRUG: D00635Help
Entry
D00635                      Drug                                   

Name
Metoprolol succinate (USP);
Toprol XL (TN)
Product
  Generic
METOPROLOL SUCCINATE (Aidarex Pharmaceuticals LLC), METOPROLOL SUCCINATE (American Health Packaging), METOPROLOL SUCCINATE (American Health Packaging), METOPROLOL SUCCINATE (Aphena Pharma Solutions - Tennessee), METOPROLOL SUCCINATE (BluePoint Laboratories), METOPROLOL SUCCINATE (BluePoint Laboratories), METOPROLOL SUCCINATE (Bryant Ranch Prepack), METOPROLOL SUCCINATE (Bryant Ranch Prepack), METOPROLOL SUCCINATE (Bryant Ranch Prepack), METOPROLOL SUCCINATE (Cardinal Health), METOPROLOL SUCCINATE (Cardinal Health), METOPROLOL SUCCINATE (Carilion Materials Management), METOPROLOL SUCCINATE (Clinical Solutions Wholesale), METOPROLOL SUCCINATE (Clinical Solutions Wholesale), METOPROLOL SUCCINATE (Dispensing Solutions), METOPROLOL SUCCINATE (Dr. Reddy's Laboratories Limited), METOPROLOL SUCCINATE (Dr. Reddy's Laboratories Limited), METOPROLOL SUCCINATE (Ethex Corporation), METOPROLOL SUCCINATE (Ethex Corporation), METOPROLOL SUCCINATE (Ethex Corporation), METOPROLOL SUCCINATE (Golden State Medical Supply), METOPROLOL SUCCINATE (Golden State Medical Supply), METOPROLOL SUCCINATE (International Labs), METOPROLOL SUCCINATE (Lake Erie Medical DBA Quality Care Products LLC), METOPROLOL SUCCINATE (Lake Erie Medical DBA Quality Care Products LLC), METOPROLOL SUCCINATE (Legacy Pharmaceutical Packaging), METOPROLOL SUCCINATE (Legacy Pharmaceutical Packaging), METOPROLOL SUCCINATE (Major Pharmaceuticals), METOPROLOL SUCCINATE (Major Pharmaceuticals), METOPROLOL SUCCINATE (Major Pharmaceuticals), METOPROLOL SUCCINATE (McKesson Packaging Services Business Unit of McKesson Corporation), METOPROLOL SUCCINATE (Mylan Institutional), METOPROLOL SUCCINATE (Mylan Pharmaceuticals), METOPROLOL SUCCINATE (NCS HealthCare of KY), METOPROLOL SUCCINATE (Northwind Pharmaceuticals), METOPROLOL SUCCINATE (Northwind Pharmaceuticals), METOPROLOL SUCCINATE (Par Pharmaceutical), METOPROLOL SUCCINATE (Physicians Total Care), METOPROLOL SUCCINATE (REMEDYREPACK), METOPROLOL SUCCINATE (REMEDYREPACK), METOPROLOL SUCCINATE (REMEDYREPACK), METOPROLOL SUCCINATE (REMEDYREPACK), METOPROLOL SUCCINATE (Rebel Distributors Corp), METOPROLOL SUCCINATE (Rebel Distributors Corp), METOPROLOL SUCCINATE (St Marys Medical Park Pharmacy), METOPROLOL SUCCINATE (St Marys Medical Park Pharmacy), METOPROLOL SUCCINATE (Unit Dose Services), METOPROLOL SUCCINATE (Unit Dose Services), METOPROLOL SUCCINATE (Unit Dose Services), METOPROLOL SUCCINATE (Watson Pharma), METOPROLOL SUCCINATE (Wockhardt Limited), METOPROLOL SUCCINATE (Wockhardt USA LLC.)
Formula
(C15H25NO3)2. C4H6O4
Exact mass
652.3935
Mol weight
652.8158
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-anginal;
Antihypertensive
Remark
ATC code: 
Drug group: 
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04970  Salivary secretion  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antiarrhythmic drugs
Antimigraines
beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AB Beta blocking agents, selective
     C07AB02 Metoprolol
      D00635  Metoprolol succinate (USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Metoprolol
    D00635  Metoprolol succinate (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Metoprolol
      D00635  Metoprolol succinate (USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Metoprolol
    D00635  Metoprolol succinate (USP)
BRITE hierarchy
Other DBs
CAS: 
98418-47-4
PubChem: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        46
            1   C1b C    34.4465  -17.7764
            2   C1b C    35.6566  -17.0789
            3   C6a C    33.2292  -17.0859
            4   C6a C    36.8737  -17.7694
            5   O6a O    32.0192  -17.7834
            6   O6a O    33.2292  -15.6837
            7   O6a O    38.0838  -17.0717
            8   O6a O    36.8737  -19.1787
            9   C8y C    28.7453  -12.4424
            10  C8x C    27.5565  -13.1416
            11  C8x C    28.7453  -11.0439
            12  O2a O    29.9340  -13.1416
            13  C8x C    26.2979  -12.4424
            14  C8x C    27.5565  -10.3447
            15  C1b C    31.1926  -12.4424
            16  C8y C    26.2979  -11.0439
            17  C1c C    32.3813  -13.1416
            18  C1b C    25.1092  -10.3447
            19  C1b C    33.5701  -12.4424
            20  O1a O    32.3813  -14.5401
            21  C1b C    23.9204  -11.0439
            22  N1b N    34.8287  -13.1416
            23  O2a O    22.6618  -10.3447
            24  C1c C    36.0174  -12.4424
            25  C1a C    21.4032  -11.1138
            26  C1a C    37.2062  -13.1416
            27  C1a C    36.0174  -11.1138
            28  C8y C    28.7453  -12.4424
            29  C8x C    27.5565  -13.1416
            30  C8x C    26.2979  -12.4424
            31  C8y C    26.2979  -11.0439
            32  C1b C    25.1092  -10.3447
            33  C1b C    23.9204  -11.0439
            34  O2a O    22.6618  -10.3447
            35  C1a C    21.4032  -11.1138
            36  C8x C    27.5565  -10.3447
            37  C8x C    28.7453  -11.0439
            38  O2a O    29.9340  -13.1416
            39  C1b C    31.1926  -12.4424
            40  C1c C    32.3813  -13.1416
            41  C1b C    33.5701  -12.4424
            42  N1b N    34.8287  -13.1416
            43  C1c C    36.0174  -12.4424
            44  C1a C    37.2062  -13.1416
            45  C1a C    36.0174  -11.1138
            46  O1a O    32.3813  -14.5401
BOND        45
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     3   6 2
            6     4   7 1
            7     4   8 2
            8     9  10 2
            9     9  11 1
            10    9  12 1
            11   10  13 1
            12   11  14 2
            13   12  15 1
            14   13  16 2
            15   15  17 1
            16   16  18 1
            17   17  19 1
            18   17  20 1
            19   18  21 1
            20   19  22 1
            21   21  23 1
            22   22  24 1
            23   23  25 1
            24   24  26 1
            25   24  27 1
            26   14  16 1
            27   28  29 2
            28   28  37 1
            29   28  38 1
            30   29  30 1
            31   37  36 2
            32   38  39 1
            33   30  31 2
            34   39  40 1
            35   31  32 1
            36   40  41 1
            37   40  46 1
            38   32  33 1
            39   41  42 1
            40   33  34 1
            41   42  43 1
            42   34  35 1
            43   43  44 1
            44   43  45 1
            45   36  31 1
BRACKET     1    19.3900  -15.1900   19.3900   -9.3100
            1    38.7800   -9.3100   38.7800  -15.1900
            1  2
 ORIGINAL  1    9  10  13  16  18  21  23  25  14  11  12  15  17  19  22  24
            1   26  27  20
 REPEAT    1   28  29  30  31  32  33  34  35  36  37  38  39  40  41  42  43
            1   44  45  46

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