KEGG   DRUG: D00635Help
Entry
D00635                      Drug                                   

Name
Metoprolol succinate (USP);
Toprol XL (TN)
Product
  Generic
METOPROLOL SUCCINATE (Aidarex Pharmaceuticals LLC), METOPROLOL SUCCINATE (American Health Packaging), METOPROLOL SUCCINATE (American Health Packaging), METOPROLOL SUCCINATE (Aphena Pharma Solutions - Tennessee), METOPROLOL SUCCINATE (BluePoint Laboratories), METOPROLOL SUCCINATE (BluePoint Laboratories), METOPROLOL SUCCINATE (Bryant Ranch Prepack), METOPROLOL SUCCINATE (Bryant Ranch Prepack), METOPROLOL SUCCINATE (Bryant Ranch Prepack), METOPROLOL SUCCINATE (Cardinal Health), METOPROLOL SUCCINATE (Cardinal Health), METOPROLOL SUCCINATE (Carilion Materials Management), METOPROLOL SUCCINATE (Clinical Solutions Wholesale), METOPROLOL SUCCINATE (Clinical Solutions Wholesale), METOPROLOL SUCCINATE (Dispensing Solutions), METOPROLOL SUCCINATE (Dr. Reddy's Laboratories Limited), METOPROLOL SUCCINATE (Dr. Reddy's Laboratories Limited), METOPROLOL SUCCINATE (Ethex Corporation), METOPROLOL SUCCINATE (Ethex Corporation), METOPROLOL SUCCINATE (Ethex Corporation), METOPROLOL SUCCINATE (Golden State Medical Supply), METOPROLOL SUCCINATE (Golden State Medical Supply), METOPROLOL SUCCINATE (International Labs), METOPROLOL SUCCINATE (Lake Erie Medical DBA Quality Care Products LLC), METOPROLOL SUCCINATE (Lake Erie Medical DBA Quality Care Products LLC), METOPROLOL SUCCINATE (Legacy Pharmaceutical Packaging), METOPROLOL SUCCINATE (Legacy Pharmaceutical Packaging), METOPROLOL SUCCINATE (Major Pharmaceuticals), METOPROLOL SUCCINATE (Major Pharmaceuticals), METOPROLOL SUCCINATE (Major Pharmaceuticals), METOPROLOL SUCCINATE (McKesson Packaging Services Business Unit of McKesson Corporation), METOPROLOL SUCCINATE (Mylan Institutional), METOPROLOL SUCCINATE (Mylan Pharmaceuticals), METOPROLOL SUCCINATE (NCS HealthCare of KY), METOPROLOL SUCCINATE (NCS HealthCare of KY), METOPROLOL SUCCINATE (NCS HealthCare of KY), METOPROLOL SUCCINATE (Northwind Pharmaceuticals), METOPROLOL SUCCINATE (Northwind Pharmaceuticals), METOPROLOL SUCCINATE (Par Pharmaceutical), METOPROLOL SUCCINATE (Physicians Total Care), METOPROLOL SUCCINATE (REMEDYREPACK), METOPROLOL SUCCINATE (REMEDYREPACK), METOPROLOL SUCCINATE (REMEDYREPACK), METOPROLOL SUCCINATE (REMEDYREPACK), METOPROLOL SUCCINATE (Rebel Distributors Corp), METOPROLOL SUCCINATE (Rebel Distributors Corp), METOPROLOL SUCCINATE (St Marys Medical Park Pharmacy), METOPROLOL SUCCINATE (St Marys Medical Park Pharmacy), METOPROLOL SUCCINATE (Unit Dose Services), METOPROLOL SUCCINATE (Unit Dose Services), METOPROLOL SUCCINATE (Unit Dose Services), METOPROLOL SUCCINATE (Watson Pharma), METOPROLOL SUCCINATE (Wockhardt Limited), METOPROLOL SUCCINATE (Wockhardt USA LLC.)
Formula
(C15H25NO3)2. C4H6O4
Exact mass
652.3935
Mol weight
652.8158
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-anginal;
Antihypertensive
Remark
ATC code: 
Drug group: 
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04970  Salivary secretion  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antiarrhythmic drugs
Antimigraines
beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AB Beta blocking agents, selective
     C07AB02 Metoprolol
      D00635  Metoprolol succinate (USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Metoprolol
    D00635  Metoprolol succinate (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Metoprolol
      D00635  Metoprolol succinate (USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Metoprolol
    D00635  Metoprolol succinate (USP)
BRITE hierarchy
Other DBs
CAS: 
98418-47-4
PubChem: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        46
            1   C1b C    31.7165  -26.4564
            2   C1b C    32.9266  -25.7589
            3   C6a C    30.4992  -25.7659
            4   C6a C    34.1437  -26.4494
            5   O6a O    29.2892  -26.4634
            6   O6a O    30.4992  -24.3637
            7   O6a O    35.3538  -25.7517
            8   O6a O    34.1437  -27.8587
            9   O2a O    17.6400  -23.5900
            10  C1b C    18.9000  -22.8900
            11  C1c C    20.0900  -23.5900
            12  C1b C    21.2800  -22.8900
            13  O1a O    20.0900  -24.9900
            14  N1b N    22.5400  -23.5900
            15  C1c C    23.7300  -22.8900
            16  C1a C    24.9200  -23.5900
            17  C1a C    23.7300  -21.5600
            18  C8y C    17.6400  -24.9900
            19  C8x C    16.4276  -25.6900
            20  C8x C    16.4276  -27.0900
            21  C8y C    17.6400  -27.7900
            22  C8x C    18.8524  -27.0900
            23  C8x C    18.8524  -25.6900
            24  C1b C    17.6400  -29.1900
            25  C1b C    16.4276  -29.8900
            26  O2a O    15.2321  -29.1996
            27  C1a C    14.0447  -29.8851
            28  O2a O    17.6400  -23.5900
            29  C1b C    18.9000  -22.8900
            30  C1c C    20.0900  -23.5900
            31  C1b C    21.2800  -22.8900
            32  N1b N    22.5400  -23.5900
            33  C1c C    23.7300  -22.8900
            34  C1a C    24.9200  -23.5900
            35  C1a C    23.7300  -21.5600
            36  O1a O    20.0900  -24.9900
            37  C8y C    17.6400  -24.9900
            38  C8x C    16.4276  -25.6900
            39  C8x C    16.4276  -27.0900
            40  C8y C    17.6400  -27.7900
            41  C8x C    18.8524  -27.0900
            42  C8x C    18.8524  -25.6900
            43  C1b C    17.6400  -29.1900
            44  C1b C    16.4276  -29.8900
            45  O2a O    15.2321  -29.1996
            46  C1a C    14.0447  -29.8851
BOND        45
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     3   6 2
            6     4   7 1
            7     4   8 2
            8     9  10 1
            9    10  11 1
            10   11  12 1
            11   11  13 1
            12   12  14 1
            13   14  15 1
            14   15  16 1
            15   15  17 1
            16    9  18 1
            17   18  19 2
            18   19  20 1
            19   20  21 2
            20   21  22 1
            21   22  23 2
            22   18  23 1
            23   21  24 1
            24   24  25 1
            25   25  26 1
            26   26  27 1
            27   28  29 1
            28   29  30 1
            29   30  31 1
            30   30  36 1
            31   31  32 1
            32   32  33 1
            33   33  34 1
            34   33  35 1
            35   28  37 1
            36   37  38 2
            37   38  39 1
            38   39  40 2
            39   40  41 1
            40   41  42 2
            41   37  42 1
            42   40  43 1
            43   43  44 1
            44   44  45 1
            45   45  46 1
BRACKET     1    11.8300  -31.1500   11.8300  -20.5800
            1    26.9500  -20.5800   26.9500  -31.1500
            1  2
 ORIGINAL  1    9  10  11  12  14  15  16  17  13  18  19  20  21  22  23  24
            1   25  26  27
 REPEAT    1   28  29  30  31  32  33  34  35  36  37  38  39  40  41  42  43
            1   44  45  46

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