KEGG   DRUG: Propafenone hydrochlorideHelp
Entry
D00640                      Drug                                   

Name
Propafenone hydrochloride (JP17/USP);
Rythmol (TN)
Product
  Generic
PROPAFENONE HYDROCHLORIDE (Mylan Pharmaceuticals), PROPAFENONE HYDROCHLORIDE (A-S Medication Solutions), PROPAFENONE HYDROCHLORIDE (ANI Pharmaceuticals), PROPAFENONE HYDROCHLORIDE (Actavis Pharma), PROPAFENONE HCL (Actavis Pharma), PROPAFENONE HYDROCHLORIDE (American Health Packaging), PROPAFENONE HYDROCHLORIDE (American Health Packaging), PROPAFENONE HCL (American Health Packaging), PROPAFENONE HYDROCHLORIDE (AvKARE), PROPAFENONE HCL (Avera McKennan Hospital), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Cardinal Health), PROPAFENONE HYDROCHLORIDE (Golden State Medical Supply), PROPAFENONE HCL (McKesson Packaging Services a business unit of McKesson Corporation), PROPAFENONE HYDROCHLORIDE (Mutual Pharmaceutical), PROPAFENONE HYDROCHLORIDE (Mylan Institutional), PROPAFENONE HYDROCHLORIDE (NCS HealthCare of KY), PROPAFENONE HYDROCHLORIDE (Par Pharmaceutical), PROPAFENONE HYDROCHLORIDE (Physicians Total Care), PROPAFENONE HYDROCHLORIDE (Prasco Laboratories), PROPAFENONE HYDROCHLORIDE (Qualitest Pharmaceuticals), PROPAFENONE (Rebel Distributors Corp)
Formula
C21H27NO3. HCl
Exact mass
377.1758
Mol weight
377.9049
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01650  Class Ic antiarrhythmic agent
Cyp substrate
 DG01892  CYP1A2 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A4 substrate
Cyp inhibitor
 DG01634  CYP1A2 inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Cardiac depressant [anti-arrhythmic]
Comment
Class I antiarrhythmic agent (Ic)
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841];
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141]
  Pathway
Adrenergic signaling in cardiomyocytes
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP1A2 [HSA:1544], CYP2D6 [HSA:1565]
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BC Antiarrhythmics, class Ic
     C01BC03 Propafenone
      D00640  Propafenone hydrochloride (JP17/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Propafenone
    D00640  Propafenone hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D00640  Propafenone hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Propafenone
      D00640  Propafenone hydrochloride (JP17/USP)
    voltage-gated sodium channel (SCN2A)
     Propafenone
      D00640  Propafenone hydrochloride (JP17/USP)
    voltage-gated sodium channel (SCN3A)
     Propafenone
      D00640  Propafenone hydrochloride (JP17/USP)
    voltage-gated sodium channel (SCN4A)
     Propafenone
      D00640  Propafenone hydrochloride (JP17/USP)
    voltage-gated sodium channel (SCN5A)
     Propafenone
      D00640  Propafenone hydrochloride (JP17/USP)
    voltage-gated sodium channel (SCN8A)
     Propafenone
      D00640  Propafenone hydrochloride (JP17/USP)
    voltage-gated sodium channel (SCN9A)
     Propafenone
      D00640  Propafenone hydrochloride (JP17/USP)
   K+ channel, KCNA, Kv1.x (Shaker)
    voltage-gated potassium channel (KCNA5)
     Propafenone
      D00640  Propafenone hydrochloride (JP17/USP)
   K+ channel, KCNK, K2px.x
    voltage-gated potassium channel (KCNK5)
     Propafenone
      D00640  Propafenone hydrochloride (JP17/USP)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP1A2
   Propafenone
    D00640  Propafenone hydrochloride (JP17/USP)
  CYP2D6
   Propafenone
    D00640  Propafenone hydrochloride (JP17/USP)
 CYP substrates
  CYP1A2
   Propafenone
    D00640  Propafenone hydrochloride (JP17/USP)
  CYP2D6
   Propafenone
    D00640  Propafenone hydrochloride (JP17/USP)
  CYP3A4
   Propafenone
    D00640  Propafenone hydrochloride (JP17/USP)
 Transporter inhibitors
  ABCB1
   Propafenone
    D00640  Propafenone hydrochloride (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00640  Propafenone hydrochloride
  D00640  Propafenone hydrochloride tablets
Phytochemicals used as drugs [BR:br08306]
 Phenylpropanoids and related compounds
  Flavonoids
   Flavonoids
    Chalcones, Dihydrochalcone, aurone and auronols
     Dihydrochalcones
      D00640  Propafenone hydrochloride (JAN/USP)
Cardiovascular agents [br08364.html]
 Antiarrhythmics
  D00640
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00640
BRITE hierarchy
Other DBs
CAS: 
34183-22-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        26
            1   C8y C    27.3415  -18.7772
            2   C8y C    27.3474  -20.1862
            3   O2a O    26.1247  -18.0844
            4   C8x C    28.5641  -18.0785
            5   C5a C    26.1363  -20.8906
            6   C8x C    28.5641  -20.8849
            7   C1b C    26.1363  -16.6871
            8   C8x C    29.7753  -18.7772
            9   C1b C    24.9311  -20.1919
            10  O5a O    26.1422  -22.2880
            11  C8x C    29.7693  -20.1803
            12  C1c C    24.9311  -15.9825
            13  C1b C    23.7259  -20.8965
            14  C1b C    23.7259  -16.6928
            15  O1a O    24.9253  -14.5851
            16  C8y C    22.5090  -20.2036
            17  N1b N    22.5149  -15.9941
            18  C8x C    22.5090  -18.8005
            19  C8x C    21.3097  -20.9082
            20  C1b C    21.3097  -16.6987
            21  C8x C    21.2921  -18.1135
            22  C8x C    20.0869  -20.2212
            23  C1b C    20.0928  -16.0000
            24  C8x C    20.0754  -18.8121
            25  C1a C    18.8819  -16.7045
            26  X   Cl   31.8596  -18.4395
BOND        26
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 1
            8     5   9 1
            9     5  10 2
            10    6  11 1
            11    7  12 1
            12    9  13 1
            13   12  14 1
            14   12  15 1
            15   13  16 1
            16   14  17 1
            17   16  18 2
            18   16  19 1
            19   17  20 1
            20   18  21 1
            21   19  22 2
            22   20  23 1
            23   21  24 2
            24   23  25 1
            25    8  11 2
            26   22  24 1

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