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Entry
D00640                      Drug                                   

Name
Propafenone hydrochloride (JP16/USP);
Rythmol (TN)
Product
  Generic
Formula
C21H27NO3. HCl
Exact mass
377.1758
Mol weight
377.9049
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Cardiac depressant [anti-arrhythmic]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Class I antiarrhythmic agent (Ic)
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841];
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes  
 
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP1A2 [HSA:1544], CYP2D6 [HSA:1565]
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BC Antiarrhythmics, class Ic
     C01BC03 Propafenone
      D00640  Propafenone hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Propafenone
    D00640  Propafenone hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D00640  Propafenone hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Propafenone
      D00640  Propafenone hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN2A)
     Propafenone
      D00640  Propafenone hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN3A)
     Propafenone
      D00640  Propafenone hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN4A)
     Propafenone
      D00640  Propafenone hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN5A)
     Propafenone
      D00640  Propafenone hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN8A)
     Propafenone
      D00640  Propafenone hydrochloride (JP16/USP)
    voltage-gated sodium channel (SCN9A)
     Propafenone
      D00640  Propafenone hydrochloride (JP16/USP)
   K+ channel, KCNA, Kv1.x (Shaker)
    voltage-gated potassium channel (KCNA5)
     Propafenone
      D00640  Propafenone hydrochloride (JP16/USP)
   K+ channel, KCNK, K2px.x
    voltage-gated potassium channel (KCNK5)
     Propafenone
      D00640  Propafenone hydrochloride (JP16/USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Propafenone
    D00640  Propafenone hydrochloride (JP16/USP)
  CYP2D6
   Propafenone
    D00640  Propafenone hydrochloride (JP16/USP)
  CYP3A4
   Propafenone
    D00640  Propafenone hydrochloride (JP16/USP)
 Inhbitors
  CYP1A2
   Propafenone
    D00640  Propafenone hydrochloride (JP16/USP)
  CYP2D6
   Propafenone
    D00640  Propafenone hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00640  Propafenone hydrochloride
  D00640  Propafenone hydrochloride tablets
Phytochemicals used as drugs [BR:br08306]
 Phenylpropanoids and related compounds
  Flavonoids
   Flavonoids
    Chalcones, Dihydrochalcone, aurone and auronols
     Dihydrochalcones
      D00640  Propafenone hydrochloride (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
34183-22-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        26
            1   C8y C    27.3415  -18.7772
            2   C8y C    27.3474  -20.1862
            3   O2a O    26.1247  -18.0844
            4   C8x C    28.5641  -18.0785
            5   C5a C    26.1363  -20.8906
            6   C8x C    28.5641  -20.8849
            7   C1b C    26.1363  -16.6871
            8   C8x C    29.7753  -18.7772
            9   C1b C    24.9311  -20.1919
            10  O5a O    26.1422  -22.2880
            11  C8x C    29.7693  -20.1803
            12  C1c C    24.9311  -15.9825
            13  C1b C    23.7259  -20.8965
            14  C1b C    23.7259  -16.6928
            15  O1a O    24.9253  -14.5851
            16  C8y C    22.5090  -20.2036
            17  N1b N    22.5149  -15.9941
            18  C8x C    22.5090  -18.8005
            19  C8x C    21.3097  -20.9082
            20  C1b C    21.3097  -16.6987
            21  C8x C    21.2921  -18.1135
            22  C8x C    20.0869  -20.2212
            23  C1b C    20.0928  -16.0000
            24  C8x C    20.0754  -18.8121
            25  C1a C    18.8819  -16.7045
            26  X   Cl   31.8596  -18.4395
BOND        26
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 1
            8     5   9 1
            9     5  10 2
            10    6  11 1
            11    7  12 1
            12    9  13 1
            13   12  14 1
            14   12  15 1
            15   13  16 1
            16   14  17 1
            17   16  18 2
            18   16  19 1
            19   17  20 1
            20   18  21 1
            21   19  22 2
            22   20  23 1
            23   21  24 2
            24   23  25 1
            25    8  11 2
            26   22  24 1

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