KEGG   DRUG: D00642Help
Entry
D00642                      Drug                                   

Name
Quinidine gluconate (USP);
Quinaglute (TN)
Product
  Generic
Formula
C20H24N2O2. C6H12O7
Exact mass
520.2421
Mol weight
520.572
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Cardiac depressant [anti-arrhythmic]
Remark
ATC code: 
Drug group: 
Comment
Class I antiarrhythmic agent
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Transporter: SLC22A1 [HSA:6580], SLC22A3 [HSA:6581]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP2D6 [HSA:1565]
Transporter inhibition: SLC22A2 [HSA:6582], SLC22A1 [HSA:6580], SLC47A1 [HSA:55244], SCL47A2 [HSA:146802], ABCB1 [HSA:5243]
Drug interaction
Structure map
Quinolines
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BA Antiarrhythmics, class Ia
     C01BA01 Quinidine
      D00642  Quinidine gluconate (USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Quinidine
    D00642  Quinidine gluconate (USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Quinidine
      D00642  Quinidine gluconate (USP)
    voltage-gated sodium channel (SCN2A)
     Quinidine
      D00642  Quinidine gluconate (USP)
    voltage-gated sodium channel (SCN3A)
     Quinidine
      D00642  Quinidine gluconate (USP)
    voltage-gated sodium channel (SCN4A)
     Quinidine
      D00642  Quinidine gluconate (USP)
    voltage-gated sodium channel (SCN5A)
     Quinidine
      D00642  Quinidine gluconate (USP)
    voltage-gated sodium channel (SCN8A)
     Quinidine
      D00642  Quinidine gluconate (USP)
    voltage-gated sodium channel (SCN9A)
     Quinidine
      D00642  Quinidine gluconate (USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Quinidine
    D00642  Quinidine gluconate (USP)
 Inhbitors
  CYP2D6
   Quinidine
    D00642  Quinidine gluconate (USP)
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from tryptophan and anthranillic acid
   Quinoline alkaloids
    D00642  Quinidine gluconate (USP)
BRITE hierarchy
Other DBs
CAS: 
7054-25-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        37
            1   C8y C    17.1259  -25.8770
            2   C8y C    18.3511  -25.1828
            3   C8y C    17.1200  -27.2832
            4   C8x C    15.9240  -25.1769
            5   C1c C    18.3568  -23.7825
            6   C8x C    19.5645  -25.8887
            7   C8x C    15.9240  -27.9891
            8   N5x N    18.3394  -27.9948
            9   C8y C    14.7046  -25.8770
            10  C1y C    19.5762  -23.0824
            11  O1a O    17.1374  -23.0707
            12  C8x C    19.5588  -27.2949
            13  C8x C    14.7046  -27.2832
            14  O2a O    13.4911  -25.1769
            15  N1y N    21.0115  -22.2073
            16  C1x C    18.8470  -22.0381
            17  C1a C    13.4911  -23.7766
            18  C1x C    21.0115  -20.9704
            19  C1x C    22.5109  -23.0124
            20  C1y C    20.2589  -21.2038
            21  C1y C    20.2647  -20.2178
            22  C1x C    21.8167  -21.9038
            23  C2b C    19.7280  -18.9109
            24  C2a C    20.5914  -17.8024
            25  C1c C    28.2753  -26.6350
            26  C1c C    27.0735  -25.9406
            27  C1c C    29.4887  -25.9406
            28  O1a O    28.2753  -28.0410
            29  C1c C    25.8598  -26.6350
            30  O1a O    27.0735  -24.5346
            31  C6a C    30.7024  -26.6350
            32  O1a O    29.4887  -24.5346
            33  C1b C    24.6464  -25.9406
            34  O1a O    25.8598  -28.0410
            35  O6a O    31.9158  -25.9406
            36  O6a O    30.7024  -28.0410
            37  O1a O    23.4327  -26.6350
BOND        39
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    5  11 1 #Down
            11    6  12 1
            12    7  13 1
            13    9  14 1
            14   10  15 1
            15   10  16 1
            16   14  17 1
            17   15  18 1
            18   15  19 1
            19   16  20 1
            20   18  21 1
            21   19  22 1
            22   21  23 1 #Up
            23   23  24 2
            24    8  12 2
            25    9  13 2
            26   20  21 1
            27   20  22 1
            28   25  26 1
            29   25  27 1
            30   25  28 1 #Up
            31   26  29 1
            32   26  30 1 #Up
            33   27  31 1
            34   27  32 1 #Up
            35   29  33 1
            36   29  34 1 #Down
            37   31  35 1
            38   31  36 2
            39   33  37 1

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