KEGG   DRUG: Quinidine gluconateHelp
Entry
D00642                      Drug                                   

Name
Quinidine gluconate (USP);
Quinaglute (TN)
Product
  Generic
Formula
C20H24N2O2. C6H12O7
Exact mass
520.2421
Mol weight
520.572
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01649  Class Ia antiarrhythmic agent
Cyp substrate
 DG01633  CYP3A substrate
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
Remark
ATC code: C01BA01
Chemical structure group: DG00192
Product (DG00192): D00642<US> D02272<JP/US>
Efficacy
Antiarrhythmic, Sodium channel blocker
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Transporter: SLC22A1 [HSA:6580], SLC22A3 [HSA:6581]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Transporter inhibition: SLC22A2 [HSA:6582], SLC22A1 [HSA:6580], SLC47A1 [HSA:55244], SCL47A2 [HSA:146802], ABCB1 [HSA:5243]
Drug interaction
Structure map
map07025  Quinolines
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BA Antiarrhythmics, class Ia
     C01BA01 Quinidine
      D00642  Quinidine gluconate (USP) <US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Quinidine
    D00642  Quinidine gluconate (USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00642  Quinidine gluconate (USP) <US>
    SCN2A
     D00642  Quinidine gluconate (USP) <US>
    SCN3A
     D00642  Quinidine gluconate (USP) <US>
    SCN4A
     D00642  Quinidine gluconate (USP) <US>
    SCN5A
     D00642  Quinidine gluconate (USP) <US>
    SCN8A
     D00642  Quinidine gluconate (USP) <US>
    SCN9A
     D00642  Quinidine gluconate (USP) <US>
    SCN10A
     D00642  Quinidine gluconate (USP) <US>
    SCN11A
     D00642  Quinidine gluconate (USP) <US>
Drug classes of therapeutic agents [br08360.html]
 Cardiovascular agents
  D00642
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00642
BRITE hierarchy
Other DBs
CAS: 7054-25-3
PubChem: 7847708
ChEBI: 27502
ChEMBL: CHEMBL1200437
DrugBank: DB00908
LigandBox: D00642
NIKKAJI: J231.528I
LinkDB All DBs
KCF data Show

ATOM        37
            1   C8y C    17.1259  -25.8770
            2   C8y C    18.3511  -25.1828
            3   C8y C    17.1200  -27.2832
            4   C8x C    15.9240  -25.1769
            5   C1c C    18.3568  -23.7825
            6   C8x C    19.5645  -25.8887
            7   C8x C    15.9240  -27.9891
            8   N5x N    18.3394  -27.9948
            9   C8y C    14.7046  -25.8770
            10  C1y C    19.5762  -23.0824
            11  O1a O    17.1374  -23.0707
            12  C8x C    19.5588  -27.2949
            13  C8x C    14.7046  -27.2832
            14  O2a O    13.4911  -25.1769
            15  N1y N    21.0115  -22.2073
            16  C1x C    18.8470  -22.0381
            17  C1a C    13.4911  -23.7766
            18  C1x C    21.0115  -20.9704
            19  C1x C    22.5109  -23.0124
            20  C1y C    20.2589  -21.2038
            21  C1y C    20.2647  -20.2178
            22  C1x C    21.8167  -21.9038
            23  C2b C    19.7280  -18.9109
            24  C2a C    20.5914  -17.8024
            25  C1c C    28.2753  -26.6350
            26  C1c C    27.0735  -25.9406
            27  C1c C    29.4887  -25.9406
            28  O1a O    28.2753  -28.0410
            29  C1c C    25.8598  -26.6350
            30  O1a O    27.0735  -24.5346
            31  C6a C    30.7024  -26.6350
            32  O1a O    29.4887  -24.5346
            33  C1b C    24.6464  -25.9406
            34  O1a O    25.8598  -28.0410
            35  O6a O    31.9158  -25.9406
            36  O6a O    30.7024  -28.0410
            37  O1a O    23.4327  -26.6350
BOND        39
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    5  11 1 #Down
            11    6  12 1
            12    7  13 1
            13    9  14 1
            14   10  15 1
            15   10  16 1
            16   14  17 1
            17   15  18 1
            18   15  19 1
            19   16  20 1
            20   18  21 1
            21   19  22 1
            22   21  23 1 #Up
            23   23  24 2
            24    8  12 2
            25    9  13 2
            26   20  21 1
            27   20  22 1
            28   25  26 1
            29   25  27 1
            30   25  28 1 #Up
            31   26  29 1
            32   26  30 1 #Up
            33   27  31 1
            34   27  32 1 #Up
            35   29  33 1
            36   29  34 1 #Down
            37   31  35 1
            38   31  36 2
            39   33  37 1

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