KEGG   DRUG: Quinidine gluconateHelp
Entry
D00642                      Drug                                   

Name
Quinidine gluconate (USP);
Quinaglute (TN)
Product
  Generic
Formula
C20H24N2O2. C6H12O7
Exact mass
520.2421
Mol weight
520.572
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01649  Class Ia antiarrhythmic agent
Cyp substrate
 DG01633  CYP3A4 substrate
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
Remark
ATC code: 
Chemical group: 
Activity
Cardiac depressant [anti-arrhythmic]
Comment
Class I antiarrhythmic agent
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Transporter: SLC22A1 [HSA:6580], SLC22A3 [HSA:6581]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP2D6 [HSA:1565]
Transporter inhibition: SLC22A2 [HSA:6582], SLC22A1 [HSA:6580], SLC47A1 [HSA:55244], SCL47A2 [HSA:146802], ABCB1 [HSA:5243]
Drug interaction
Structure map
Quinolines
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BA Antiarrhythmics, class Ia
     C01BA01 Quinidine
      D00642  Quinidine gluconate (USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Quinidine
    D00642  Quinidine gluconate (USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Quinidine
      D00642  Quinidine gluconate (USP)
    voltage-gated sodium channel (SCN2A)
     Quinidine
      D00642  Quinidine gluconate (USP)
    voltage-gated sodium channel (SCN3A)
     Quinidine
      D00642  Quinidine gluconate (USP)
    voltage-gated sodium channel (SCN4A)
     Quinidine
      D00642  Quinidine gluconate (USP)
    voltage-gated sodium channel (SCN5A)
     Quinidine
      D00642  Quinidine gluconate (USP)
    voltage-gated sodium channel (SCN8A)
     Quinidine
      D00642  Quinidine gluconate (USP)
    voltage-gated sodium channel (SCN9A)
     Quinidine
      D00642  Quinidine gluconate (USP)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2D6
   Quinidine
    D00642  Quinidine gluconate (USP)
 CYP substrates
  CYP3A4
   Quinidine
    D00642  Quinidine gluconate (USP)
  CYP3A
   Quinidine
    D00642  Quinidine gluconate (USP)
 Transporter inhibitors
  ABCB1
   Quinidine
    D00642  Quinidine gluconate (USP)
  SLC22A1
   Quinidine
    D00642  Quinidine gluconate (USP)
  SLC22A2
   Quinidine
    D00642  Quinidine gluconate (USP)
  MATE1
   Quinidine
    D00642  Quinidine gluconate (USP)
  MATE2
   Quinidine
    D00642  Quinidine gluconate (USP)
 Transporter substrates
  ABCB1
   Quinidine
    D00642  Quinidine gluconate (USP)
  SLC22A1
   Quinidine
    D00642  Quinidine gluconate (USP)
  SLC22A3
   Quinidine
    D00642  Quinidine gluconate (USP)
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from tryptophan and anthranillic acid
   Quinoline alkaloids
    D00642  Quinidine gluconate (USP)
Cardiovascular agents [br08364.html]
 Antiarrhythmics
  D00642
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00642
BRITE hierarchy
Other DBs
CAS: 
7054-25-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        37
            1   C8y C    17.1259  -25.8770
            2   C8y C    18.3511  -25.1828
            3   C8y C    17.1200  -27.2832
            4   C8x C    15.9240  -25.1769
            5   C1c C    18.3568  -23.7825
            6   C8x C    19.5645  -25.8887
            7   C8x C    15.9240  -27.9891
            8   N5x N    18.3394  -27.9948
            9   C8y C    14.7046  -25.8770
            10  C1y C    19.5762  -23.0824
            11  O1a O    17.1374  -23.0707
            12  C8x C    19.5588  -27.2949
            13  C8x C    14.7046  -27.2832
            14  O2a O    13.4911  -25.1769
            15  N1y N    21.0115  -22.2073
            16  C1x C    18.8470  -22.0381
            17  C1a C    13.4911  -23.7766
            18  C1x C    21.0115  -20.9704
            19  C1x C    22.5109  -23.0124
            20  C1y C    20.2589  -21.2038
            21  C1y C    20.2647  -20.2178
            22  C1x C    21.8167  -21.9038
            23  C2b C    19.7280  -18.9109
            24  C2a C    20.5914  -17.8024
            25  C1c C    28.2753  -26.6350
            26  C1c C    27.0735  -25.9406
            27  C1c C    29.4887  -25.9406
            28  O1a O    28.2753  -28.0410
            29  C1c C    25.8598  -26.6350
            30  O1a O    27.0735  -24.5346
            31  C6a C    30.7024  -26.6350
            32  O1a O    29.4887  -24.5346
            33  C1b C    24.6464  -25.9406
            34  O1a O    25.8598  -28.0410
            35  O6a O    31.9158  -25.9406
            36  O6a O    30.7024  -28.0410
            37  O1a O    23.4327  -26.6350
BOND        39
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    5  11 1 #Down
            11    6  12 1
            12    7  13 1
            13    9  14 1
            14   10  15 1
            15   10  16 1
            16   14  17 1
            17   15  18 1
            18   15  19 1
            19   16  20 1
            20   18  21 1
            21   19  22 1
            22   21  23 1 #Up
            23   23  24 2
            24    8  12 2
            25    9  13 2
            26   20  21 1
            27   20  22 1
            28   25  26 1
            29   25  27 1
            30   25  28 1 #Up
            31   26  29 1
            32   26  30 1 #Up
            33   27  31 1
            34   27  32 1 #Up
            35   29  33 1
            36   29  34 1 #Down
            37   31  35 1
            38   31  36 2
            39   33  37 1

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