KEGG   DRUG: D00809Help
Entry
D00809                      Drug                                   

Name
Amitriptyline hydrochloride (JP16/USP);
Elavil (TN)
Product
  Generic
AMITRIPTYLINE HYDROCHLORIDE (A-S Medication Solutions LLC), AMITRIPTYLINE HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), AMITRIPTYLINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), AMITRIPTYLINE HYDROCHLORIDE (Blenheim Pharmacal), AMITRIPTYLINE HYDROCHLORIDE (Blenheim Pharmacal), AMITRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), AMITRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), AMITRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), AMITRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), AMITRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), AMITRIPTYLINE HYDROCHLORIDE (C.O. Truxton), AMITRIPTYLINE HYDROCHLORIDE (Cardinal Health), AMITRIPTYLINE HYDROCHLORIDE (Clinical Solutions Wholesale), AMITRIPTYLINE HYDROCHLORIDE (Clinical Solutions Wholesale), AMITRIPTYLINE HYDROCHLORIDE (Contract Pharmacy Services-PA), AMITRIPTYLINE HYDROCHLORIDE (Contract Pharmacy Services-PA), AMITRIPTYLINE HYDROCHLORIDE (DIRECT RX), AMITRIPTYLINE HYDROCHLORIDE (Direct Rx), AMITRIPTYLINE HYDROCHLORIDE (Direct Rx), AMITRIPTYLINE HYDROCHLORIDE (Dispensing Solutions), AMITRIPTYLINE HYDROCHLORIDE (Dispensing Solutions), AMITRIPTYLINE HYDROCHLORIDE (Dispensing Solutions), AMITRIPTYLINE HYDROCHLORIDE (Dispensing Solutions), AMITRIPTYLINE HYDROCHLORIDE (H.J. Harkins Company), AMITRIPTYLINE HYDROCHLORIDE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), AMITRIPTYLINE HYDROCHLORIDE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), AMITRIPTYLINE HYDROCHLORIDE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), AMITRIPTYLINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), AMITRIPTYLINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), AMITRIPTYLINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), AMITRIPTYLINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), AMITRIPTYLINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), AMITRIPTYLINE HYDROCHLORIDE (Major Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (MedVantx), AMITRIPTYLINE HYDROCHLORIDE (Mylan Institutional), AMITRIPTYLINE HYDROCHLORIDE (Mylan Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (NCS HealthCare of KY), AMITRIPTYLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Physicians Total Care), AMITRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (Qualitest Pharmaceuticals), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), AMITRIPTYLINE HYDROCHLORIDE (Rebel Distributors Corp.), AMITRIPTYLINE HYDROCHLORIDE (STAT RX USA LLC), AMITRIPTYLINE HYDROCHLORIDE (STAT RX USA LLC), AMITRIPTYLINE HYDROCHLORIDE (STAT Rx USA LLC), AMITRIPTYLINE HYDROCHLORIDE (STAT Rx USA LLC), AMITRIPTYLINE HYDROCHLORIDE (Sandoz), AMITRIPTYLINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), AMITRIPTYLINE HYDROCHLORIDE (Unit Dose Services), AMITRIPTYLINE HYDROCHLORIDE (Unit Dose Services), AMITRIPTYLINE HYDROCHLORIDE (Unit Dose Services), AMITRIPTYLINE HYDROCHLORIDE (Unit Dose Services), AMITRIPTYLINE HYDROCHLORIDE (Unit Dose Services), AMITRIPTYLINE HYDROCHLORIDE (bryant ranch prepack)
Formula
C20H23N. HCl
Exact mass
313.1597
Mol weight
313.8643
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidepressant
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Tricyclic antidepressants
Target
serotonin transporter inhibitor [HSA:6532] [KO:K05037];
noradrenalin transporter inhibitor [HSA:6530] [KO:K05035]
  Pathway
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2C19 [HSA:1557], CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antidepressants
Antimigraines
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AA Non-selective monoamine reuptake inhibitors
     N06AA09 Amitriptyline
      D00809  Amitriptyline hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Antidepressants
  Tricyclics
   Amitriptyline
    D00809  Amitriptyline hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00809  Amitriptyline hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter)
     Amitriptyline
      D00809  Amitriptyline hydrochloride (JP16/USP)
    SLC6A4 (serotonin transporter)
     Amitriptyline
      D00809  Amitriptyline hydrochloride (JP16/USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Amitriptyline
    D00809  Amitriptyline hydrochloride (JP16/USP)
  CYP2C19
   Amitriptyline
    D00809  Amitriptyline hydrochloride (JP16/USP)
  CYP2D6
   Amitriptyline
    D00809  Amitriptyline hydrochloride (JP16/USP)
  CYP3A4
   Amitriptyline
    D00809  Amitriptyline hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00809  Amitriptyline hydrochloride
  D00809  Amitriptyline hydrochloride tablets
BRITE hierarchy
Other DBs
CAS: 
549-18-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        22
            1   C1x C    22.3053  -18.3173
            2   C8y C    21.4609  -17.2047
            3   C8y C    21.7970  -15.8442
            4   C2y C    23.0615  -15.2645
            5   C1x C    23.7149  -18.3426
            6   C8y C    24.3184  -15.8885
            7   C8y C    24.6057  -17.2610
            8   C8x C    20.7871  -14.8731
            9   C8x C    19.4414  -15.2623
            10  C8x C    19.1053  -16.6228
            11  C8x C    20.1152  -17.5936
            12  C8x C    25.9405  -17.6993
            13  C8x C    26.9876  -16.7623
            14  C8x C    26.7005  -15.3898
            15  C8x C    25.3654  -14.9515
            16  C2b C    23.0132  -13.8858
            17  C1b C    24.2405  -13.2028
            18  C1b C    25.4121  -13.9042
            19  N1c N    26.6376  -13.2223
            20  C1a C    27.8757  -13.9629
            21  C1a C    26.6597  -11.8503
            22  X   Cl   29.9627  -16.4829
BOND        23
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 2
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   19  21 1

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