KEGG   DRUG: D00811Help
Entry
D00811                      Drug                                   

Name
Clomipramine hydrochloride (JP16/USP);
Anafranil (TN)
Product
  Generic
Formula
C19H23ClN2. HCl
Exact mass
350.1317
Mol weight
351.3133
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidepressant
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
serotonin norepinephrine reuptake inhibitor
Tricyclic antidepressants
Target
serotonin transporter inhibitor [HSA:6532] [KO:K05037];
noradrenalin transporter inhibitor [HSA:6530] [KO:K05035]
  Pathway
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2C19 [HSA:1557], CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AA Non-selective monoamine reuptake inhibitors
     N06AA04 Clomipramine
      D00811  Clomipramine hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Antidepressants
  Tricyclics
   Clomipramine
    D00811  Clomipramine hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1174  Imipramines
     D00811  Clomipramine hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter)
     Clomipramine
      D00811  Clomipramine hydrochloride (JP16/USP)
    SLC6A4 (serotonin transporter)
     Clomipramine
      D00811  Clomipramine hydrochloride (JP16/USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Clomipramine
    D00811  Clomipramine hydrochloride (JP16/USP)
  CYP2C19
   Clomipramine
    D00811  Clomipramine hydrochloride (JP16/USP)
  CYP2D6
   Clomipramine
    D00811  Clomipramine hydrochloride (JP16/USP)
  CYP3A4
   Clomipramine
    D00811  Clomipramine hydrochloride (JP16/USP)
 Inhbitors
  CYP2D6
   Clomipramine
    D00811  Clomipramine hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00811  Clomipramine hydrochloride
BRITE hierarchy
Other DBs
CAS: 
17321-77-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        23
            1   C1x C    18.7534  -14.2894
            2   C8y C    17.9113  -13.1798
            3   C8y C    18.2465  -11.8230
            4   N1y N    19.5075  -11.2449
            5   C1x C    20.1592  -14.3146
            6   C8y C    20.7611  -11.8672
            7   C8y C    21.0476  -13.2359
            8   C8x C    17.2394  -10.8546
            9   C8y C    15.8974  -11.2427
            10  C8x C    15.5622  -12.5995
            11  C8x C    16.5693  -13.5676
            12  C8x C    22.3788  -13.6730
            13  C8x C    23.4230  -12.7386
            14  C8x C    23.1366  -11.3699
            15  C8x C    21.8052  -10.9328
            16  X   Cl   14.8980  -10.2821
            17  C1b C    19.5292   -9.8700
            18  C1b C    20.7532   -9.1889
            19  C1b C    21.9216   -9.8884
            20  N1c N    23.1437   -9.2083
            21  C1a C    24.3784   -9.9469
            22  C1a C    23.1657   -7.8400
            23  X   Cl   26.3900  -12.4600
BOND        24
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    9  16 1
            19    4  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   20  22 1

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