KEGG   DRUG: D00812Help
Entry
D00812                      Drug                                   

Name
Desipramine hydrochloride (JAN/USP);
Norpramin (TN)
Product
  Generic
DESIPRAMINE HYDROCHLORIDE (Actavis Pharma), DESIPRAMINE HYDROCHLORIDE (Bryant Ranch Prepack), DESIPRAMINE HYDROCHLORIDE (Bryant Ranch Prepack), DESIPRAMINE HYDROCHLORIDE (Bryant Ranch Prepack), DESIPRAMINE HYDROCHLORIDE (Carilion Materials Management), DESIPRAMINE HYDROCHLORIDE (KAISER FOUNDATION HOSPITALS), DESIPRAMINE HYDROCHLORIDE (Preferred Pharmaceuticals), DESIPRAMINE HYDROCHLORIDE (REMEDYREPACK), DESIPRAMINE HYDROCHLORIDE (REMEDYREPACK), DESIPRAMINE HYDROCHLORIDE (REMEDYREPACK), DESIPRAMINE HYDROCHLORIDE (REMEDYREPACK), DESIPRAMINE HYDROCHLORIDE (REMEDYREPACK), DESIPRAMINE HYDROCHLORIDE (Rebel Distributors Corp), DESIPRAMINE HYDROCHLORIDE (Rebel Distributors Corp), DESIPRAMINE HYDROCHLORIDE (STAT RX USA LLC), DESIPRAMINE HYDROCHLORIDE (Sandoz), DESIPRAMINE HYDROCHLORIDE (Winthrop U.S.)
Formula
C18H22N2. HCl
Exact mass
302.155
Mol weight
302.8416
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidepressant
Remark
ATC code: 
Drug group: 
Comment
Tricyclic antidepressants
Target
serotonin transporter inhibitor [HSA:6532] [KO:K05037];
noradrenalin transporter inhibitor [HSA:6530] [KO:K05035]
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AA Non-selective monoamine reuptake inhibitors
     N06AA01 Desipramine
      D00812  Desipramine hydrochloride (JAN/USP)
USP drug classification [BR:br08302]
 Antidepressants
  Tricyclics
   Desipramine
    D00812  Desipramine hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter)
     Desipramine
      D00812  Desipramine hydrochloride (JAN/USP)
    SLC6A4 (serotonin transporter)
     Desipramine
      D00812  Desipramine hydrochloride (JAN/USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Desipramine
    D00812  Desipramine hydrochloride (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
58-28-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        21
            1   C1x C    12.5108  -18.1831
            2   C8y C    11.6661  -17.0701
            3   C8y C    12.0023  -15.7092
            4   N1y N    13.2672  -15.1293
            5   C1x C    13.9209  -18.2084
            6   C8y C    14.5246  -15.7535
            7   C8y C    14.8120  -17.1264
            8   C8x C    10.9921  -14.7378
            9   C8x C     9.6460  -15.1271
            10  C8x C     9.3098  -16.4880
            11  C8x C    10.3200  -17.4591
            12  C8x C    16.1472  -17.5648
            13  C8x C    17.1946  -16.6276
            14  C8x C    16.9074  -15.2547
            15  C8x C    15.5719  -14.8162
            16  C1b C    13.2889  -13.7502
            17  C1b C    14.5167  -13.0670
            18  C1b C    15.6886  -13.7686
            19  N1b N    16.9145  -13.0865
            20  C1a C    18.1530  -13.8273
            21  X   Cl   20.1707  -16.3481
BOND        22
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1

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