KEGG   DRUG: D00816Help
Entry
D00816                      Drug                                   

Name
Nortriptyline hydrochloride (JP16/USP/INN);
Pamelor (TN)
Product
  Generic
NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), NORTRIPTYLINE HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), NORTRIPTYLINE HYDROCHLORIDE (American Health Packaging), NORTRIPTYLINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Cardinal Health), NORTRIPTYLINE HYDROCHLORIDE (Clinical Solutions Wholesale), NORTRIPTYLINE HYDROCHLORIDE (Clinical Solutions Wholesale), NORTRIPTYLINE HYDROCHLORIDE (Direct Rx), NORTRIPTYLINE HYDROCHLORIDE (Dispensing Solutions), NORTRIPTYLINE HYDROCHLORIDE (KAISER FOUNDATION HOSPITALS), NORTRIPTYLINE HYDROCHLORIDE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), NORTRIPTYLINE HYDROCHLORIDE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), NORTRIPTYLINE HYDROCHLORIDE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), NORTRIPTYLINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), NORTRIPTYLINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), NORTRIPTYLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (Pharmaceutical Associates), NORTRIPTYLINE HYDROCHLORIDE (Physicians Total Care), NORTRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (Rebel Distributors Corp), NORTRIPTYLINE HYDROCHLORIDE (STAT RX USA LLC), NORTRIPTYLINE HYDROCHLORIDE (St Marys Medical Park Pharmacy), NORTRIPTYLINE HYDROCHLORIDE (Taro Pharmaceuticals U.S.A.), NORTRIPTYLINE HYDROCHLORIDE (Teva Pharmaceuticals USA), NORTRIPTYLINE HYDROCHLORIDE (Unit Dose Services), NORTRIPTYLINE HYDROCHLORIDE (Unit Dose Services), NORTRIPTYLINE HYDROCHLORIDE (Unit Dose Services), NORTRIPTYLINE HYDROCHLORIDE (Watson Laboratories)
Formula
C19H21N. HCl
Exact mass
299.1441
Mol weight
299.8377
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidepressant
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
norepinephrine reuptake inhibitor
Tricyclic antidepressants
Target
serotonin transporter inhibitor [HSA:6532] [KO:K05037];
noradrenalin transporter inhibitor [HSA:6530] [KO:K05035]
  Pathway
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antidepressants
Antimigraines
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AA Non-selective monoamine reuptake inhibitors
     N06AA10 Nortriptyline
      D00816  Nortriptyline hydrochloride (JP16/USP/INN)
USP drug classification [BR:br08302]
 Antidepressants
  Tricyclics
   Nortriptyline
    D00816  Nortriptyline hydrochloride (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00816  Nortriptyline hydrochloride (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter)
     Nortriptyline
      D00816  Nortriptyline hydrochloride (JP16/USP/INN)
    SLC6A4 (serotonin transporter)
     Nortriptyline
      D00816  Nortriptyline hydrochloride (JP16/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Nortriptyline
    D00816  Nortriptyline hydrochloride (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00816  Nortriptyline hydrochloride
BRITE hierarchy
Other DBs
CAS: 
894-71-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        21
            1   C1x C    11.2452  -10.4773
            2   C8y C    10.4008   -9.3647
            3   C8y C    10.7369   -8.0042
            4   C2y C    12.0014   -7.4245
            5   C1x C    12.6548  -10.5026
            6   C8y C    13.2583   -8.0485
            7   C8y C    13.5456   -9.4210
            8   C8x C     9.7270   -7.0331
            9   C8x C     8.3814   -7.4223
            10  C8x C     8.0453   -8.7828
            11  C8x C     9.0551   -9.7536
            12  C8x C    14.8804   -9.8593
            13  C8x C    15.9275   -8.9223
            14  C8x C    15.6404   -7.5498
            15  C8x C    14.3053   -7.1115
            16  C2b C    11.9531   -6.0458
            17  C1b C    13.1804   -5.3628
            18  C1b C    14.3520   -6.0642
            19  N1b N    15.5775   -5.3823
            20  C1a C    16.8156   -6.1229
            21  X   Cl   18.9026   -8.6429
BOND        22
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 2
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1

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