KEGG   DRUG: Venlafaxine hydrochlorideHelp
Entry
D00821                      Drug                                   

Name
Venlafaxine hydrochloride (JAN/USAN);
Effexor (TN)
Product
  Generic
VENLAFAXINE (Aidarex Pharmaceuticals LLC), VENLAFAXINE (Aidarex Pharmaceuticals LLC), VENLAFAXINE (Aidarex Pharmaceuticals LLC), VENLAFAXINE (Aidarex Pharmaceuticals LLC), VENLAFAXINE (Aidarex Pharmaceuticals LLC), VENLAFAXINE (Aidarex Pharmaceuticals LLC), VENLAFAXINE (Alembic Pharmaceuticals), VENLAFAXINE (Alembic Pharmaceuticals Limited), VENLAFAXINE (American Health Packaging), VENLAFAXINE HYDROCHLORIDE (Amneal Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (AvPAK), VENLAFAXINE (Avera McKennan Hospital), VENLAFAXINE (Avera McKennan Hospital), VENLAFAXINE (BluePoint Laboratories), VENLAFAXINE (Bryant Ranch Prepack), VENLAFAXINE (Bryant Ranch Prepack), VENLAFAXINE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE (Clinical Solutions Wholesale), VENLAFAXINE (Contract Pharmacy Services-PA), VENLAFAXINE (Contract Pharmacy Services-PA), VENLAFAXINE (DIRECT RX), EFFEXOR (DIRECT RX), VENLAFAXINE (DIRECT RX), VENLAFAXINE (Direct Rx), VENLAFAXINE (DirectRX), VENLAFAXINE (DirectRX), VENLAFAXINE (Heritage Pharmaceuticals), VENLAFAXINE (KAISER FOUNDATION HOSPITALS), VENLAFAXINE (NCS HealthCare of KY), VENLAFAXINE (NCS HealthCare of KY), VENLAFAXINE (NorthStar RxLLC), VENLAFAXINE (Northstar Rx LLC), VENLAFAXINE (NuCare Pharmaceuticals), VENLAFAXINE (NuCare Pharmaceuticals), VENLAFAXINE (PD-Rx Pharmaceuticals), VENLAFAXINE (Proficient Rx LP), VENLAFAXINE (Proficient Rx LP), VENLAFAXINE (Proficient Rx LP), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE (State of Florida DOH Central Pharmacy), VENLAFAXINE (Sun Pharmaceutical Industries), VENLAFAXINE (Zydus Pharmaceuticals (USA)), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), VENLAFAXINE HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), VENLAFAXINE HYDROCHLORIDE (American Health Packaging), VENLAFAXINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VENLAFAXINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VENLAFAXINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VENLAFAXINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VENLAFAXINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VENLAFAXINE HYDROCHLORIDE (Aurobindo Pharma Limited), VENLAFAXINE (Aurobindo Pharma Limited), VENLAFAXINE HYDROCHLORIDE (AvKARE), VENLAFAXINE HYDROCHLORIDE (AvKARE), VENLAFAXINE HYDROCHLORIDE (Avera McKennan Hospital), VENLAFAXINE HYDROCHLORIDE (Avera McKennan Hospital), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Cadila Healthcare Limited), VENLAFAXINE HYDROCHLORIDE (Cadila Healthcare Limited), VENLAFAXINE HYDROCHLORIDE (Carilion Materials Management), VENLAFAXINE HYDROCHLORIDE (Carilion Materials Management), VENLAFAXINE HYDROCHLORIDE (Carilion Materials Management), VENLAFAXINE HYDROCHLORIDE (Clinical Solutions Wholesale), VENLAFAXINE HYDROCHLORIDE (Clinical Solutions Wholesale), VENLAFAXINE HYDROCHLORIDE (DIRECT RX), VENLAFAXINE HYDROCHLORIDE (DIRECT RX), VENLAFAXINE HYDROCHLORIDE (DIRECT RX), VENLAFAXINE HYDROCHLORIDE (Dr. Reddy's Laboratories Limited), VENLAFAXINE HYDROCHLORIDE (Dr.Reddy's Laboratories), VENLAFAXINE HYDROCHLORIDE (Golden State Medical Supply), VENLAFAXINE HYDROCHLORIDE (Golden State Medical Supply), VENLAFAXINE HYDROCHLORIDE (Greenstone LLC), VENLAFAXINE HYDROCHLORIDE (H.J. Harkins Company), VENLAFAXINE HYDROCHLORIDE (KAISER FOUNDATION HOSPITALS), VENLAFAXINE HYDROCHLORIDE (KAISER FOUNDATION HOSPITALS), VENLAFAXINE HYDROCHLORIDE (LUCID PHARMA LLC), VENLAFAXINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), VENLAFAXINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), VENLAFAXINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), VENLAFAXINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), VENLAFAXINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), VENLAFAXINE HYDROCHLORIDE (Macleods Pharmaceuticals Limited), VENLAFAXINE HYDROCHLORIDE (Major Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Major Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (McKesson Corporation), VENLAFAXINE HYDROCHLORIDE (McKesson Corporation), VENLAFAXINE HYDROCHLORIDE (MedVantx), VENLAFAXINE HYDROCHLORIDE (Medsource Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Mylan Institutional), VENLAFAXINE HYDROCHLORIDE (Mylan Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NCS HealthCare of KY), VENLAFAXINE HYDROCHLORIDE (Nostrum Laboratories), VENLAFAXINE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Orchid Healthcare (a division of Orchid Chemicals & Pharmaceuticals Ltd.)), VENLAFAXINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Physicians Total Care), VENLAFAXINE HYDROCHLORIDE (Physicians Total Care), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Proficient Rx LP), VENLAFAXINE HYDROCHLORIDE (Proficient Rx LP), VENLAFAXINE HYDROCHLORIDE (Proficient Rx LP), VENLAFAXINE HYDROCHLORIDE (Proficient Rx LP), VENLAFAXINE HYDROCHLORIDE (QPharma), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (RPK Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Rebel Distributors Corp), VENLAFAXINE HYDROCHLORIDE (Rebel Distributors Corp.), VENLAFAXINE (Rising Health), VENLAFAXINE HYDROCHLORIDE (RxChange), VENLAFAXINE (St. Mary's Medical Park Pharmacy), VENLAFAXINE (St. Mary's Medical Park Pharmacy), VENLAFAXINE HYDROCHLORIDE (St. Marys Medical Park Pharmacy), VENLAFAXINE HYDROCHLORIDE (Sun Pharma Global FZE), VENLAFAXINE HYDROCHLORIDE (TYA Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Teva Pharmaceuticals USA), VENLAFAXINE HYDROCHLORIDE (Teva Pharmaceuticals USA), VENLAFAXINE HYDROCHLORIDE (Torrent Pharmaceuticals Limited), VENLAFAXINE HYDROCHLORIDE (Trigen Laboratories), VENLAFAXINE (Trupharma), VENLAFAXINE HYDROCHLORIDE (Unit Dose Services), VENLAFAXINE HYDROCHLORIDE (Unit Dose Services), VENLAFAXINE HYDROCHLORIDE (Unit Dose Services), VENLAFAXINE HYDROCHLORIDE (Vertical Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Wockhardt Limited), VENLAFAXINE HYDROCHLORIDE (Wockhardt USA LLC.), VENLAFAXINE HYDROCHLORIDE (Yaopharma), VENLAFAXINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals)
Formula
C17H27NO2. HCl
Exact mass
313.1809
Mol weight
313.8627
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01658  Serotonin and norepinephrine reuptake inhibitor
Cyp substrate
 DG01644  CYP2D6 substrate
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Therapeutic category: 1179
ATC code: N06AX16
Chemical structure group: DG00959
Product (DG00959): D00821<JP/US>
Efficacy
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI)
  Disease
Major depressive disorder [DS:H01646]
Generalized anxiety disorder [DS:H01662]
Social anxiety disorder [DS:H01670]
Panic disorder [DS:H01664]
Comment
serotonin norepinephrine reuptake inhibitor (SNRI)
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
  Pathway
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]; CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07027  Antidepressants
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX16 Venlafaxine
      D00821  Venlafaxine hydrochloride (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Venlafaxine
    D00821  Venlafaxine hydrochloride (JAN/USAN)
 Anxiolytics
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Venlafaxine
    D00821  Venlafaxine hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00821  Venlafaxine hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D00821  Venlafaxine hydrochloride (JAN/USAN) <JP/US>
    SLC6A4 (HTT)
     D00821  Venlafaxine hydrochloride (JAN/USAN) <JP/US>
Drug classes of therapeutic agents [br08360.html]
 Psychiatric agents
  D00821
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00821
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00821
BRITE hierarchy
Other DBs
CAS: 99300-78-4
PubChem: 7847886
ChEBI: 9944
ChEMBL: CHEMBL1201066
DrugBank: DB00285
LigandBox: D00821
NIKKAJI: J397.344A
LinkDB All DBs
KCF data Show

ATOM        21
            1   X   Cl   27.9676  -14.4620
            2   C8x C    18.0600  -14.7700
            3   C8y C    18.0600  -16.1700
            4   C8x C    19.2724  -16.8700
            5   C8x C    20.4849  -16.1700
            6   C8y C    20.4849  -14.7700
            7   C8x C    19.2724  -14.0700
            8   C1x C    22.9097  -16.1700
            9   C1z C    22.9097  -14.7700
            10  C1c C    21.6973  -14.0700
            11  C1x C    24.1222  -16.8700
            12  C1x C    25.3346  -16.1700
            13  C1x C    25.3346  -14.7700
            14  C1x C    24.1222  -14.0700
            15  O2a O    16.8476  -16.8700
            16  C1a C    15.6521  -16.1796
            17  C1b C    21.6973  -12.6700
            18  O1a O    22.9097  -13.3700
            19  N1c N    20.4869  -11.9712
            20  C1a C    19.2924  -12.6610
            21  C1a C    20.4868  -10.5702
BOND        21
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     8   9 1
            8     9  10 1
            9     6  10 1
            10    8  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14    9  14 1
            15    3  15 1
            16   15  16 1
            17   10  17 1
            18    9  18 1
            19   17  19 1
            20   19  20 1
            21   19  21 1

» Japanese version   » Back

DBGET integrated database retrieval system