KEGG   DRUG: Fluvoxamine maleateHelp
Entry
D00824                      Drug                                   

Name
Fluvoxamine maleate (JP17/USAN);
Luvox (TN)
Product
  Generic
Formula
C15H21F3N2O2. C4H4O4
Exact mass
434.1665
Mol weight
434.4068
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01659  Selective serotonin reuptake inhibitor
Cyp substrate
 DG01892  CYP1A2 substrate
 DG01639  CYP2C19 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A4 substrate
Cyp inhibitor
 DG01634  CYP1A2 inhibitor
 DG01641  CYP2C8 inhibitor
 DG01643  CYP2C9 inhibitor
 DG01522  CYP3A4 inhibitor
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antidepressant, SSRI
Comment
Selective serotonin reuptake inhibitor (SSRI)
Agent of antiobsessional
Target
serotonin transporter inhibitor [HSA:6532] [KO:K05037]
  Pathway
Serotonergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576], CYP2D6 [HSA:1565], CYP2C19 [HSA:1557]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP1A2 [HSA:1544], CYP2C8 [HSA:1558], CYP2C9 [HSA:1559], CYP2C19 [HSA:1557], CYP2D6 [HSA:1565], CYP3A [HSA:1576 1577 1551]
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AB Selective serotonin reuptake inhibitors
     N06AB08 Fluvoxamine
      D00824  Fluvoxamine maleate (JP17/USAN)
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP17/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00824  Fluvoxamine maleate (JP17/USAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (serotonin transporter)
     Fluvoxamine
      D00824  Fluvoxamine maleate (JP17/USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP1A2
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP17/USAN)
  CYP2C8
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP17/USAN)
  CYP2C9
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP17/USAN)
  CYP2C19
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP17/USAN)
  CYP3A
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP17/USAN)
 CYP inducers
  CYP2C8
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP17/USAN)
 CYP substrates
  CYP1A2
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP17/USAN)
  CYP2C19
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP17/USAN)
  CYP2D6
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP17/USAN)
  CYP3A4
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP17/USAN)
 Transporter inhibitors
  ABCB1
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP17/USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00824  Fluvoxamine maleate
  D00824  Fluvoxamine maleate tablets
Psychiatric agents [br08363.html]
 Antidepressants
  D00824
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00824
BRITE hierarchy
Other DBs
CAS: 
61718-82-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        30
            1   C2b C    39.7600  -15.4000
            2   C2b C    41.4400  -15.4000
            3   C6a C    39.0600  -16.5900
            4   C6a C    42.1400  -16.5900
            5   O6a O    37.6600  -16.5900
            6   O6a O    39.7600  -17.7800
            7   O6a O    41.4400  -17.7800
            8   O6a O    43.5400  -16.5900
            9   C8y C    23.5900  -14.4900
            10  C8x C    23.5900  -15.8900
            11  C8x C    24.7800  -16.5900
            12  C8y C    26.0400  -15.8900
            13  C8x C    26.0400  -14.4900
            14  C8x C    24.7800  -13.7900
            15  C1d C    22.4000  -13.7900
            16  X   F    21.1400  -13.0900
            17  X   F    23.0300  -12.5300
            18  X   F    21.7700  -15.0500
            19  C2c C    27.2300  -16.5900
            20  C1b C    28.4900  -15.8900
            21  N2b N    27.2300  -17.9900
            22  O2a O    28.4900  -18.6900
            23  C1b C    29.6800  -17.9900
            24  C1b C    30.8700  -18.6900
            25  N1a N    32.0600  -17.9900
            26  C1b C    29.6100  -16.5900
            27  C1b C    30.8700  -15.8900
            28  C1b C    32.0600  -16.5900
            29  O2a O    33.2500  -15.8900
            30  C1a C    34.4400  -16.5900
BOND        29
            1     1   2 2
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     3   6 2
            6     4   7 1
            7     4   8 2
            8     9  10 2
            9    10  11 1
            10   11  12 2
            11   12  13 1
            12   13  14 2
            13    9  14 1
            14    9  15 1
            15   15  16 1
            16   15  17 1
            17   15  18 1
            18   12  19 1
            19   19  20 1
            20   19  21 2
            21   21  22 1
            22   22  23 1
            23   23  24 1
            24   24  25 1
            25   20  26 1
            26   26  27 1
            27   27  28 1
            28   28  29 1
            29   29  30 1

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