KEGG   DRUG: D00824Help
Entry
D00824                      Drug                                   

Name
Fluvoxamine maleate (JP16/USAN);
Luvox (TN)
Product
  Generic
Formula
C15H21F3N2O2. C4H4O4
Exact mass
434.1665
Mol weight
434.4068
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiobsessional agent
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Selective serotonin reuptake inhibitor (SSRI)
Target
serotonin transporter inhibitor [HSA:6532] [KO:K05037]
  Pathway
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576], CYP2D6 [HSA:1565], CYP2C19 [HSA:1557]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP1A2 [HSA:1544], CYP2C8 [HSA:1558], CYP2C9 [HSA:1559], CYP2C19 [HSA:1557], CYP3A [HSA:1576 1577 1551]
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AB Selective serotonin reuptake inhibitors
     N06AB08 Fluvoxamine
      D00824  Fluvoxamine maleate (JP16/USAN)
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP16/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00824  Fluvoxamine maleate (JP16/USAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (serotonin transporter)
     Fluvoxamine
      D00824  Fluvoxamine maleate (JP16/USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP16/USAN)
  CYP2C19
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP16/USAN)
  CYP2D6
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP16/USAN)
  CYP3A4
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP16/USAN)
 Inhbitors
  CYP1A2
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP16/USAN)
  CYP2C8
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP16/USAN)
  CYP2C9
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP16/USAN)
  CYP2C19
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP16/USAN)
  CYP3A
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP16/USAN)
 Inducers
  CYP2C8
   Fluvoxamine
    D00824  Fluvoxamine maleate (JP16/USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00824  Fluvoxamine maleate
  D00824  Fluvoxamine maleate tablets
BRITE hierarchy
Other DBs
CAS: 
61718-82-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        30
            1   C2b C    39.7600  -15.4000
            2   C2b C    41.4400  -15.4000
            3   C6a C    39.0600  -16.5900
            4   C6a C    42.1400  -16.5900
            5   O6a O    37.6600  -16.5900
            6   O6a O    39.7600  -17.7800
            7   O6a O    41.4400  -17.7800
            8   O6a O    43.5400  -16.5900
            9   C8y C    23.5900  -14.4900
            10  C8x C    23.5900  -15.8900
            11  C8x C    24.7800  -16.5900
            12  C8y C    26.0400  -15.8900
            13  C8x C    26.0400  -14.4900
            14  C8x C    24.7800  -13.7900
            15  C1d C    22.4000  -13.7900
            16  X   F    21.1400  -13.0900
            17  X   F    23.0300  -12.5300
            18  X   F    21.7700  -15.0500
            19  C2c C    27.2300  -16.5900
            20  C1b C    28.4900  -15.8900
            21  N2b N    27.2300  -17.9900
            22  O2a O    28.4900  -18.6900
            23  C1b C    29.6800  -17.9900
            24  C1b C    30.8700  -18.6900
            25  N1a N    32.0600  -17.9900
            26  C1b C    29.6100  -16.5900
            27  C1b C    30.8700  -15.8900
            28  C1b C    32.0600  -16.5900
            29  O2a O    33.2500  -15.8900
            30  C1a C    34.4400  -16.5900
BOND        29
            1     1   2 2
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     3   6 2
            6     4   7 1
            7     4   8 2
            8     9  10 2
            9    10  11 1
            10   11  12 2
            11   12  13 1
            12   13  14 2
            13    9  14 1
            14    9  15 1
            15   15  16 1
            16   15  17 1
            17   15  18 1
            18   12  19 1
            19   19  20 1
            20   19  21 2
            21   21  22 1
            22   22  23 1
            23   23  24 1
            24   24  25 1
            25   20  26 1
            26   26  27 1
            27   27  28 1
            28   28  29 1
            29   29  30 1

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