KEGG   DRUG: D00893Help
Entry
D00893                      Drug                                   

Name
Pravastatin sodium (JP16/USAN);
CS-514;
Pravachol (TN)
Product
  Generic
PRAVASTATIN SODIUM (Aidarex Pharmaceuticals LLC), PRAVASTATIN SODIUM (American Health Packaging), PRAVASTATIN SODIUM (Aphena Pharma Solutions - Tennessee), PRAVASTATIN SODIUM (Aphena Pharma Solutions - Tennessee), PRAVASTATIN SODIUM (Apotex Corp.), PRAVASTATIN SODIUM (AvKARE), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Cadila Healthcare Limited), PRAVASTATIN SODIUM (Cardinal Health), PRAVASTATIN SODIUM (Cardinal Health), PRAVASTATIN SODIUM (Cardinal Health), PRAVASTATIN SODIUM (Cardinal Health), PRAVASTATIN SODIUM (Cardinal Health), PRAVASTATIN SODIUM (Clinical Solutions Wholesale), PRAVASTATIN SODIUM (Cobalt Laboratories), PRAVASTATIN SODIUM (Dr.Reddy's Laboratories Limited), PRAVASTATIN SODIUM (Glenmark Generics), PRAVASTATIN SODIUM (Golden State Medical Supply), PRAVASTATIN SODIUM (International Labs), PRAVASTATIN SODIUM (International Labs), PRAVASTATIN SODIUM (International Labs), PRAVASTATIN SODIUM (Lake Erie Medical DBA Quality Care Products LLC), PRAVASTATIN SODIUM (Lupin Pharmaceuticals), PRAVASTATIN SODIUM (Major Pharmaceuticals), PRAVASTATIN SODIUM (Major Pharmaceuticals), PRAVASTATIN SODIUM (McKesson Contract Packaging), PRAVASTATIN SODIUM (MedVantx), PRAVASTATIN SODIUM (Mylan Institutional), PRAVASTATIN SODIUM (Mylan Pharmaceuticals), PRAVASTATIN SODIUM (NCS HealthCare of KY), PRAVASTATIN (NCS HealthCare of KY), PRAVASTATIN SODIUM (NCS HealthCare of KY), PRAVASTATIN SODIUM (Northwind Pharmaceuticals), PRAVASTATIN SODIUM (Northwind Pharmaceuticals), PRAVASTATIN SODIUM (Northwind Pharmaceuticals), PRAVASTATIN SODIUM (PD-Rx Pharmaceuticals), PRAVASTATIN SODIUM (PD-Rx Pharmaceuticals), PRAVASTATIN SODIUM (PD-Rx Pharmaceuticals), PRAVASTATIN SODIUM (PD-Rx Pharmaceuticals), PRAVASTATIN SODIUM (Physicians Total Care), PRAVASTATIN SODIUM (Preferred Pharmaceuticals), PRAVASTATIN SODIUM (REMEDYREPACK), PRAVASTATIN SODIUM (REMEDYREPACK), PRAVASTATIN SODIUM (REMEDYREPACK), PRAVASTATIN SODIUM (REMEDYREPACK), PRAVASTATIN SODIUM (REMEDYREPACK), PRAVASTATIN SODIUM (REMEDYREPACK), PRAVASTATIN SODIUM (REMEDYREPACK), PRAVASTATIN SODIUM (REMEDYREPACK), PRAVASTATIN SODIUM (REMEDYREPACK), PRAVASTATIN SODIUM (REMEDYREPACK), PRAVASTATIN SODIUM (REMEDYREPACK), PRAVASTATIN SODIUM (REMEDYREPACK), PRAVASTATIN SODIUM (REMEDYREPACK), PRAVASTATIN SODIUM (REMEDYREPACK), PRAVASTATIN SODIUM (Rebel Distributors Corp), PRAVASTATIN SODIUM (Rebel Distributors Corp), PRAVASTATIN SODIUM (Rebel Distributors Corp), PRAVASTATIN SODIUM (Sandoz), PRAVASTATIN SODIUM (Sandoz), PRAVASTATIN SODIUM (St Marys Medical Park Pharmacy), PRAVASTATIN SODIUM (State of Florida DOH Central Pharmacy), PRAVASTATIN SODIUM (State of Florida DOH Central Pharmacy), PRAVASTATIN SODIUM (State of Florida DOH Central Pharmacy), PRAVASTATIN SODIUM (State of Florida DOH Central Pharmacy), PRAVASTATIN SODIUM (State of Florida DOH Central Pharmacy), PRAVASTATIN SODIUM (Teva Pharmaceuticals USA), PRAVASTATIN SODIUM (Teva Pharmaceuticals USA), PRAVASTATIN SODIUM (Unit Dose Services), PRAVASTATIN SODIUM (Unit Dose Services), PRAVASTATIN SODIUM (Zydus Pharmaceuticals (USA))
Formula
C23H35O7. Na
Exact mass
446.228
Mol weight
446.5096
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihyperlipidemic [DS:H00153 H00155 H00156]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor [HSA:3156] [KO:K00021]
  Pathway
hsa00900  Terpenoid backbone biosynthesis
hsa04976  Bile secretion  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Transporter: ABCB11 [HSA:8647], SLCO1B1 [HSA:10599], SLC22A8 [HSA:9376]
Interaction
Genomic biomarker: LDLR [HSA:3949]
Transporter inhibition: ABCB11 (BSEP) [HSA:8647]
Drug interaction
Structure map
HMG-CoA reductase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AA HMG CoA reductase inhibitors
     C10AA03 Pravastatin
      D00893  Pravastatin sodium (JP16/USAN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, HMG CoA Reductase Inhibitors
   Pravastatin
    D00893  Pravastatin sodium (JP16/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   218  Hyperlipidemia agents
    2189  Others
     D00893  Pravastatin sodium (JP16/USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase
    Pravastatin
     D00893  Pravastatin sodium (JP16/USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Pravastatin
    D00893  Pravastatin sodium (JP16/USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00893  Pravastatin sodium
  D00893  Pravastatin sodium solution
  D00893  Pravastatin sodium fine granules
  D00893  Pravastatin sodium tablets
BRITE hierarchy
Other DBs
CAS: 
81131-70-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        31
            1   C1y C    23.0209  -21.3559
            2   C1y C    24.2277  -20.6597
            3   C1y C    21.8141  -20.6540
            4   C2y C    23.0152  -22.7543
            5   C1y C    25.4345  -21.3675
            6   C1b C    24.2335  -19.2674
            7   C1x C    20.6014  -21.3559
            8   O7a O    21.7444  -18.9309
            9   C2x C    21.8141  -23.4447
            10  C2x C    24.2161  -23.4506
            11  C2x C    25.4288  -22.7600
            12  C1a C    26.6471  -20.6713
            13  C1b C    25.4460  -18.5768
            14  C1y C    20.6014  -22.7543
            15  C7a C    20.6536  -18.2287
            16  O1a O    19.3947  -23.4447
            17  C1c C    19.4469  -18.9250
            18  O6a O    20.6536  -16.8362
            19  C1b C    18.2402  -18.2287
            20  C1a C    19.4469  -20.3174
            21  C1a C    17.0276  -18.9250
            22  C1c C    25.4276  -17.1575
            23  C1b C    24.2075  -16.4743
            24  O1a O    26.6293  -16.4427
            25  C1c C    24.2156  -15.0601
            26  C1b C    25.4307  -14.3679
            27  O1a O    23.0087  -14.3541
            28  C6a C    26.8259  -14.3609
            29  O6a O    27.5310  -15.5685 #-
            30  O6a O    27.5189  -13.1465
            31  Z   Na   29.1409  -15.4559 #+
BOND        31
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1 #Up
            6     3   7 1
            7     3   8 1 #Down
            8     4   9 2
            9     4  10 1
            10    5  11 1
            11    5  12 1 #Up
            12    6  13 1
            13    7  14 1
            14    8  15 1
            15   14  16 1 #Up
            16   15  17 1
            17   15  18 2
            18   17  19 1
            19   17  20 1 #Up
            20   19  21 1
            21    9  14 1
            22   10  11 2
            23   22  13 1 #Down
            24   22  23 1
            25   22  24 1
            26   23  25 1
            27   25  26 1
            28   25  27 1 #Up
            29   26  28 1
            30   28  29 1
            31   28  30 2

» Japanese version   » Back

DBGET integrated database retrieval system