KEGG   DRUG: Tolterodine tartrateHelp
Entry
D01148                      Drug                                   

Name
Tolterodine tartrate (JAN/USAN);
Detrol (TN);
Detrusitol (TN)
Product
  Generic
Formula
C22H31NO. C4H6O6
Exact mass
475.257
Mol weight
475.5745
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
Cyp substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Overactive bladder agent, Muscarinic antagonist
Comment
Treatment of urinary incontinence
Target
CHRM3 [HSA:1131] [KO:K04131]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BD Urinary antispasmodics
     G04BD07 Tolterodine
      D01148  Tolterodine tartrate (JAN/USAN)
USP drug classification [BR:br08302]
 Genitourinary Agents
  Antispasmodics, Urinary
   Tolterodine
    D01148  Tolterodine tartrate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  25  Urogenital and anal organ agents
   259  Miscellaneous
    2590  Miscellaneous
     D01148  Tolterodine tartrate (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor M3
     Tolterodine
      D01148  Tolterodine tartrate (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2D6
   Tolterodine
    D01148  Tolterodine tartrate (JAN/USAN)
  CYP3A4
   Tolterodine
    D01148  Tolterodine tartrate (JAN/USAN)
Endocrine and hormonal agents [br08373.html]
 Other urological agents
  D01148
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D01148
BRITE hierarchy
Other DBs
CAS: 
124937-52-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        34
            1   O6a O    22.5567  -17.4447
            2   C6a C    23.7680  -16.7435
            3   C1c C    24.9791  -17.4447
            4   C1c C    26.1905  -16.7435
            5   C6a C    27.4018  -17.4447
            6   O6a O    28.6130  -16.7435
            7   O6a O    23.7680  -15.3410
            8   O1a O    24.9791  -18.8472
            9   O1a O    26.1905  -15.3410
            10  O6a O    27.4018  -18.8472
            11  C1c C     9.8068  -16.8754
            12  N1c N    11.0205  -17.5762
            13  C1b C    12.2344  -16.8754
            14  C1b C    13.4481  -17.5762
            15  C1c C    14.6618  -16.8754
            16  C8y C    15.8756  -17.5762
            17  C8x C    17.0894  -16.8754
            18  C8y C    18.3032  -17.5762
            19  C1a C    19.5170  -16.8754
            20  C1a C     8.5930  -17.5762
            21  C1a C     9.8068  -15.4739
            22  C1c C    11.0205  -18.9775
            23  C1a C     9.7899  -19.6882
            24  C1a C    12.2175  -19.6687
            25  C8y C    14.6618  -15.4740
            26  C8y C    15.8756  -18.9774
            27  C8x C    18.3032  -18.9776
            28  C8x C    17.1102  -19.6905
            29  O1a O    14.6827  -19.6663
            30  C8x C    15.8607  -14.7817
            31  C8x C    15.8606  -13.3802
            32  C8x C    14.6468  -12.6795
            33  C8x C    13.4479  -13.3718
            34  C8x C    13.4480  -14.7733
BOND        34
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     2   7 2
            7     3   8 1 #Up
            8     4   9 1 #Up
            9     5  10 2
            10   11  12 1
            11   12  13 1
            12   13  14 1
            13   15  14 1 #Down
            14   15  16 1
            15   16  17 1
            16   17  18 2
            17   18  19 1
            18   11  20 1
            19   11  21 1
            20   12  22 1
            21   22  23 1
            22   22  24 1
            23   15  25 1
            24   16  26 2
            25   18  27 1
            26   26  28 1
            27   28  27 2
            28   26  29 1
            29   25  30 2
            30   30  31 1
            31   31  32 2
            32   32  33 1
            33   33  34 2
            34   25  34 1

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