KEGG   DRUG: D01164Help
Entry
D01164                      Drug                                   

Name
Aripiprazole (JAN/USAN/INN);
Abilify (TN)
Product
ABILIFY (Aphena Pharma Solutions - Tennessee), ABILIFY (Bryant Ranch Prepack), ABILIFY (Bryant Ranch Prepack), ABILIFY (Bryant Ranch Prepack), ABILIFY (Cardinal Health), ABILIFY (Carilion Materials Management), ABILIFY (Carilion Materials Management), ABILIFY (Carilion Materials Management), ABILIFY (H.J. Harkins Company), ABILIFY (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ABILIFY (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ABILIFY (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ABILIFY (Lake Erie Medical DBA Quality Care Products LLC), ABILIFY (Lake Erie Medical Surgical & Supply DBA Quality Care Products LLC), ABILIFY (Otsuka America Pharmaceutical), ABILIFY MAINTENA (Otsuka America Pharmaceutical), ABILIFY (PD-Rx Pharmaceuticals), ABILIFY (Physicians Total Care), ABILIFY (REMEDYREPACK), ABILIFY (REMEDYREPACK), ABILIFY (REMEDYREPACK), ABILIFY (Rebel Distributors Corp.), ABILIFY (STAT RX USA LLC), ABILIFY (TYA Pharmaceuticals), ABILIFY (TYA Pharmaceuticals)
  Generic
Formula
C23H27Cl2N3O2
Exact mass
447.148
Mol weight
448.3854
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antipsychotic: Antischizophrenic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Dopamine system stabilizer (Dopamine-serotonin system stabilizer) (DSS)
Target
dopamine D2-receptor agonist/antagonist [HSA:1813] [KO:K04145];
5-HT2A-receptor antagonist [HSA:3356] [KO:K04157];
5-HT1A-receptor agonist/antagonist [HSA:3350] [KO:K04153]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AX Other antipsychotics
     N05AX12 Aripiprazole
      D01164  Aripiprazole (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Antidepressants
  Antidepressants, Other
   Aripiprazole
    D01164  Aripiprazole (JAN/USAN/INN)
 Antipsychotics
  2nd Generation/Atypical
   Aripiprazole
    D01164  Aripiprazole (JAN/USAN/INN)
 Bipolar Agents
  Bipolar Agents, Other
   Aripiprazole
    D01164  Aripiprazole (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01164  Aripiprazole (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor
     Aripiprazole
      D01164  Aripiprazole (JAN/USAN/INN)
   Serotonin
    5-HT1A-receptor
     Aripiprazole
      D01164  Aripiprazole (JAN/USAN/INN)
    5-HT2A-receptor
     Aripiprazole
      D01164  Aripiprazole (JAN/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Aripiprazole
    D01164  Aripiprazole (JAN/USAN/INN)
  CYP3A4
   Aripiprazole
    D01164  Aripiprazole (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
129722-12-9
PubChem: 
DrugBank: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        30
            1   C8y C    21.1093  -20.1077
            2   C8x C    21.1093  -18.7072
            3   C8x C    19.8936  -18.0069
            4   C8x C    19.8936  -20.8080
            5   C8y C    18.6849  -20.1077
            6   C8y C    18.6910  -18.7072
            7   C1x C    16.2652  -18.6969
            8   C5x C    16.2592  -20.0974
            9   N1x N    17.4691  -20.8027
            10  O5x O    15.0434  -20.7924
            11  O2a O    22.3219  -20.8085
            12  C1b C    23.5352  -20.1089
            13  C1b C    24.7476  -20.8099
            14  C1b C    25.9609  -20.1101
            15  C1b C    27.1735  -20.8110
            16  N1y N    28.3868  -20.1115
            17  C1x C    29.5955  -20.8116
            18  C1x C    30.8088  -20.1120
            19  N1y N    30.8094  -18.7115
            20  C1x C    29.5970  -18.0105
            21  C1x C    28.4537  -18.7103
            22  C8y C    32.0227  -18.0119
            23  C8y C    33.2328  -18.7123
            24  C8y C    34.4460  -18.0127
            25  C8x C    34.4467  -16.6123
            26  C8x C    33.2341  -15.9114
            27  C8x C    32.0208  -16.6111
            28  X   Cl   33.2316  -20.1128
            29  X   Cl   35.6585  -18.7137
            30  C1x C    17.4783  -18.0066
BOND        33
            1     5   4 2
            2    14  15 1
            3     5   6 1
            4    15  16 1
            5    30   7 1
            6     7   8 1
            7     8   9 1
            8     9   5 1
            9     4   1 1
            10   16  17 1
            11   17  18 1
            12   18  19 1
            13   19  20 1
            14   20  21 1
            15   21  16 1
            16    8  10 2
            17   19  22 1
            18    1  11 1
            19    1   2 2
            20   11  12 1
            21    2   3 1
            22   22  23 2
            23   23  24 1
            24   24  25 2
            25   25  26 1
            26   26  27 2
            27   27  22 1
            28   12  13 1
            29   23  28 1
            30    3   6 2
            31   24  29 1
            32   13  14 1
            33    6  30 1

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