KEGG   DRUG: D01355Help
Entry
D01355                      Drug                                   

Name
Tramadol hydrochloride (JAN/USAN);
Ultram (TN)
Product
ULTRAM (A-S Medication Solutions LLC), TRAMADOL HYDROCHLORIDE (A-S Medication Solutions LLC), TRAMADOL HYDROCHLORIDE (DIRECT RX), TRAMADOL HYDROCHLORIDE (H.J. Harkins Company), ULTRAM ER (Janssen Pharmaceuticals), ULTRAM (Janssen Pharmaceuticals), TRAMADOL HYDROCHLORIDE (KLE 2), ULTRAM (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), RYZOLT (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ULTRAM ER (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), TRAMADOL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), ULTRAM (Lake Erie Medical DBA Quality Care Products LLC), ULTRAM (PD-Rx Pharmaceuticals), TRAMADOL HYDROCHLORIDE (Patriot Pharmaceuticals), TRAMADOL HYDROCHLORIDE (Preferred Pharmaceuticals), TRAMADOL HYDROCHLORIDE (Proficient Rx LP), ULTRAM (REMEDYREPACK), TRAMADOL HYDROCHLORIDE (REMEDYREPACK), TRAMADOL HYDROCHLORIDE (REMEDYREPACK), ULTRAM ER (Rebel Distributors Corp), RYBIX (Shionogi), RYZOLT (Stat Rx USA), TRAMADOL HYDROCHLORIDE (Unit Dose Services), CONZIP (Vertical Pharmaceuticals), CONZIP (Vertical Pharmaceuticals)
  Generic
TRAMADOL ER (Stat Rx USA), ULTRAM (NORTHWIND PHARMACEUTICALS), TRAMADOL HYDROCHLORIDE (A-S Medication Solutions LLC), TRAMADOL HYDROCHLORIDE (A-S Medication Solutions LLC), TRAMADOL HYDROCHLORIDE (A-S Medication Solutions LLC), TRAMADOL HYDROCHLORIDE (APOTHECA), TRAMADOL HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), TRAMADOL HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), TRAMADOL HYDROCHLORIDE (Altura Pharmaceuticals), TRAMADOL HYDROCHLORIDE (American Health Packaging), TRAMADOL HYDROCHLORIDE (Amneal Pharmaceuticals of New York), TRAMADOL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), TRAMADOL HYDROCHLORIDE (Apotex Corp.), TRAMADOL HYDROCHLORIDE (Aurobindo Pharma Limited), TRAMADOL HYDROCHLORIDE (Blenheim Pharmacal), TRAMADOL HYDROCHLORIDE (Bryant Ranch Prepack), TRAMADOL HYDROCHLORIDE (Bryant Ranch Prepack), TRAMADOL HYDROCHLORIDE (Bryant Ranch Prepack), TRAMADOL HYDROCHLORIDE (Cadila Healthcare Limited), TRAMADOL HYDROCHLORIDE (Cardinal Health), TRAMADOL HYDROCHLORIDE (Cardinal Health), TRAMADOL HYDROCHLORIDE (Cardinal Health), TRAMADOL HYDROCHLORIDE (Cardinal Health), TRAMADOL HYDROCHLORIDE (Cardinal Health), TRAMADOL HYDROCHLORIDE (Cardinal Health), TRAMADOL HYDROCHLORIDE (Contract Pharmacy Services-PA), TRAMADOL HYDROCHLORIDE (Direct Rx), TRAMADOL HYDROCHLORIDE (Dispensing Solutions), TRAMADOL HYDROCHLORIDE (Dispensing Solutions), TRAMADOL HYDROCHLORIDE (Keltman Pharmaceuticals), TRAMADOL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), TRAMADOL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), TRAMADOL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), TRAMADOL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), TRAMADOL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), TRAMADOL HYDROCHLORIDE (Life Line Home Care Services), TRAMADOL HYDROCHLORIDE (Lupin Pharmaceuticals), TRAMADOL HYDROCHLORIDE (Lupin Pharmaceuticals), TRAMADOL HYDROCHLORIDE (Major Pharmaceuticals), TRAMADOL HYDROCHLORIDE (Major Pharmaceuticals), TRAMADOL HYDROCHLORIDE (McKesson Contract Packaging), TRAMADOL HYDROCHLORIDE (McKesson Packaging Services a business unit of McKesson Corporation), TRAMADOL HYDROCHLORIDE (Med-Health Pharma), TRAMADOL HYDROCHLORIDE (Mylan Institutional), TRAMADOL HYDROCHLORIDE (Mylan Pharmaceuticals), TRAMADOL HYDROCHLORIDE (Northstar RxLLC), TRAMADOL HYDROCHLORIDE (PD-Rx Pharmaceuticals), TRAMADOL HYDROCHLORIDE (PD-Rx Pharmaceuticals), TRAMADOL HYDROCHLORIDE (Par Pharmaceutical), TRAMADOL HYDROCHLORIDE (Physicians Total Care), TRAMADOL HYDROCHLORIDE (Physicians Total Care), TRAMADOL HYDROCHLORIDE (Preferred Pharmaceuticals), TRAMADOL HYDROCHLORIDE (Proficient Rx LP), TRAMADOL HYDROCHLORIDE (REMEDYREPACK), TRAMADOL HYDROCHLORIDE (REMEDYREPACK), TRAMADOL HYDROCHLORIDE (REMEDYREPACK), TRAMADOL HYDRCHLORIDE (REMEDYREPACK), TRAMADOL HYDROCHLORIDE (REMEDYREPACK), TRAMADOL HYDROCHLORIDE (REMEDYREPACK), TRAMADOL HYDROCHLORIDE (REMEDYREPACK), TRAMADOL HYDRCHLORIDE (REMEDYREPACK), TRAMADOL HYDROCHLORIDE (REMEDYREPACK), TRAMADOL HYDROCHLORIDE (REMEDYREPACK), TRAMADOL HYDROCHLORIDE (REMEDYREPACK), TRAMADOL HYDROCHLORIDE (ReadyMeds), TRAMADOL HYDROCHLORIDE (Rebel Distributors Corp.), TRAMADOL HYDROCHLORIDE (Rebel Distributors Corp.), TRAMADOL HYDROCHLORIDE (STAT Rx USA LLC), TRAMADOL HYDROCHLORIDE (STAT Rx USA LLC), TRAMADOL HYDROCHLORIDE (St. Marys Medical Park Pharmacy), TRAMADOL HYDROCHLORIDE (Sun Pharma Global FZE), TRAMADOL HYDROCHLORIDE (Sun Pharma Global FZE), TRAMADOL HYDROCHLORIDE (Sun Pharmaceutical Industries), TRAMADOL HYDROCHLORIDE (Teva Pharmaceuticals USA), TRAMADOL HYDROCHLORIDE (Unit Dose Services), TRAMADOL HYDROCHLORIDE (Unit Dose Services), TRAMADOL HYDROCHLORIDE (Virtus Pharmaceuticals LLC), TRAMADOL HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), TRAMADOL HYDROCHLORIDE (Par Pharmaceutical), TRAMADOL (Accord Healthcare)
Formula
C16H25NO2. HCl
Exact mass
299.1652
Mol weight
299.8361
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Analgesic
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
mu-opioid receptor agonist [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AX Other opioids
     N02AX02 Tramadol
      D01355  Tramadol hydrochloride (JAN/USAN)
USP drug classification [BR:br08302]
 Analgesics
  Opioid Analgesics, Long-acting
   Tramadol
    D01355  Tramadol hydrochloride (JAN/USAN)
  Opioid Analgesics, Short-acting
   Tramadol
    D01355  Tramadol hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D01355  Tramadol hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    mu-opioid receptor
     Tramadol
      D01355  Tramadol hydrochloride (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Tramadol
    D01355  Tramadol hydrochloride (JAN/USAN)
  CYP3A4
   Tramadol
    D01355  Tramadol hydrochloride (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
36282-47-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        20
            1   C1z C    21.0055  -18.6181
            2   C8y C    22.2165  -19.3259
            3   C1y C    21.0114  -17.2258
            4   C1x C    19.7888  -19.3201
            5   O1a O    21.0114  -20.0162
            6   C8x C    23.4274  -18.6298
            7   C8x C    22.2107  -20.7299
            8   C1x C    19.7945  -16.5238
            9   C1b C    22.2222  -16.5238
            10  C1x C    18.5836  -18.6239
            11  C8y C    24.6325  -19.3318
            12  C8x C    23.4215  -21.4319
            13  C1x C    18.5778  -17.2258
            14  N1c N    22.2222  -15.1257
            15  C8x C    24.6384  -20.7359
            16  O2a O    25.8494  -18.6298
            17  C1a C    23.4332  -14.4236
            18  C1a C    21.0114  -14.4236
            19  C1a C    27.0603  -19.3318
            20  X   Cl   31.3776  -18.7645
BOND        20
            1     1   2 1 #Up
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Down
            5     2   6 2
            6     2   7 1
            7     3   8 1
            8     3   9 1 #Down
            9     4  10 1
            10    6  11 1
            11    7  12 2
            12    8  13 1
            13    9  14 1
            14   11  15 2
            15   11  16 1
            16   14  17 1
            17   14  18 1
            18   16  19 1
            19   10  13 1
            20   12  15 1

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