KEGG   DRUG: Fentanyl citrateHelp
Entry
D01399                      Drug                                   

Name
Fentanyl citrate (JP17/USP);
Abstral (TN);
Fentora (TN);
Lazanda (TN);
Oralet (TN)
Product
  Generic
  Other
FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company), FENTANYL CITRATE (Cantrell Drug Company)
Formula
C22H28N2O. C6H8O7
Exact mass
528.2472
Mol weight
528.594
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG02027  General anesthetics
   DG02026  Opioid anesthetics
 DG02027  General anesthetics
  DG02026  Opioid anesthetics
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Cyp substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Efficacy
Analgesic (narcotic), Opioid receptor agonist
Comment
Phenylpiperidine derivative
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
Drug interaction
Structure map
Opioid analgesics
Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01A ANESTHETICS, GENERAL
    N01AH Opioid anesthetics
     N01AH01 Fentanyl
      D01399  Fentanyl citrate (JP17/USP)
  N02 ANALGESICS
   N02A OPIOIDS
    N02AB Phenylpiperidine derivatives
     N02AB03 Fentanyl
      D01399  Fentanyl citrate (JP17/USP)
USP drug classification [BR:br08302]
 Analgesics
  Opioid Analgesics, Long-acting
   Fentanyl
    D01399  Fentanyl citrate (JP17/USP)
  Opioid Analgesics, Short-acting
   Fentanyl
    D01399  Fentanyl citrate (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 8  Narcotics
  82  Non-alkaloidal narcotics
   821  Synthetic narcotics
    8219  Others
     D01399  Fentanyl citrate (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    mu-opioid receptor
     Fentanyl
      D01399  Fentanyl citrate (JP17/USP)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP3A4
   Fentanyl
    D01399  Fentanyl citrate (JP17/USP)
  CYP3A5
   Fentanyl
    D01399  Fentanyl citrate (JP17/USP)
  CYP3A7
   Fentanyl
    D01399  Fentanyl citrate (JP17/USP)
  CYP3A
   Fentanyl
    D01399  Fentanyl citrate (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01399  Fentanyl citrate
Anesthetics, analgesics and anti-inflammatory drugs [br08369.html]
 Analgesics
  D01399
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01399
BRITE hierarchy
Other DBs
CAS: 
990-73-8
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        38
            1   C1d C    39.8723  -15.9084
            2   C1b C    38.6652  -16.6023
            3   C1b C    41.0794  -16.5964
            4   C6a C    40.5604  -14.6954
            5   O1a O    39.1666  -14.6954
            6   C6a C    37.4638  -15.9142
            7   C6a C    41.0677  -17.9902
            8   O6a O    39.8547  -13.4825
            9   O6a O    41.9600  -14.6954
            10  O6a O    36.2569  -16.6140
            11  O6a O    37.4522  -14.5205
            12  O6a O    42.2749  -18.6900
            13  O6a O    39.8547  -18.6840
            14  N1c N    25.4800  -15.0500
            15  C1y C    26.7400  -15.7500
            16  C8y C    24.2900  -15.7500
            17  C5a C    25.4800  -13.6500
            18  C1x C    26.7400  -17.1500
            19  C1x C    27.9300  -15.0500
            20  C8x C    23.1000  -15.0500
            21  C8x C    24.2900  -17.1500
            22  C1b C    26.7400  -12.9500
            23  O5a O    24.2900  -12.9500
            24  C1x C    27.9300  -17.8500
            25  C1x C    29.1200  -15.7500
            26  C8x C    21.8400  -15.7500
            27  C8x C    23.0300  -17.8500
            28  C1a C    27.9300  -13.6500
            29  N1y N    29.1200  -17.1500
            30  C8x C    21.8400  -17.0800
            31  C1b C    30.3800  -17.8500
            32  C1b C    31.5700  -17.1500
            33  C8y C    32.7600  -17.8500
            34  C8x C    32.7600  -19.2500
            35  C8x C    34.0200  -17.1500
            36  C8x C    34.0200  -19.9500
            37  C8x C    35.2100  -17.8500
            38  C8x C    35.2100  -19.2500
BOND        39
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 2
            9     6  10 1
            10    6  11 2
            11    7  12 1
            12    7  13 2
            13   14  15 1
            14   14  16 1
            15   14  17 1
            16   15  18 1
            17   15  19 1
            18   16  20 2
            19   16  21 1
            20   17  22 1
            21   17  23 2
            22   18  24 1
            23   19  25 1
            24   20  26 1
            25   21  27 2
            26   22  28 1
            27   24  29 1
            28   26  30 2
            29   29  31 1
            30   31  32 1
            31   32  33 1
            32   33  34 1
            33   33  35 2
            34   34  36 2
            35   35  37 1
            36   36  38 1
            37   25  29 1
            38   27  30 1
            39   37  38 2

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