KEGG   DRUG: Imatinib mesylateHelp
Entry
D01441                      Drug                                   

Name
Imatinib mesylate (USAN);
Imatinib mesilate (JAN);
Gleevec (TN);
Glivec (TN)
Product
  Generic
Formula
C29H31N7O. CH4SO3
Exact mass
589.2471
Mol weight
589.7084
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
Cyp substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A4 substrate
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
 DG01522  CYP3A4 inhibitor
Transporter substrate
 DG01665  P-glycoprotein substrate
 DG01913  BCRP substrate
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antineoplastic, Tyrosine kinase inhibitor
  Disease
Chronic myeloid leukemia (Philadelphia chromosome positive) [DS:H00004]
Acute lymphoblastic leukemia (Philadelphia chromosome positive) [DS:H00001]
Hypereosinophilic syndrome (FIP1L1-PDGFRA positive) [DS:H01599]
Chronic eosinophilic leukemia (FIP1L1-PDGFRA positive) [DS:H01590]
Gastrointestinal stromal tumors (KIT positive) [DS:H01591]
Target
BCR-ABL [HSA:25] [KO:K06619];
FIP1L1-PDGFRA [HSA:5156] [KO:K04363];
KIT (CD117) [HSA:3815] [KO:K05091]
  Pathway
MAPK signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Pathways in cancer
Chronic myeloid leukemia
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP2D6 [HSA:1565], CYP2C9 [HSA:1559]
Transporter: ABCB1 [HSA:5243], ABCG2 [HSA:9429]
Interaction
Genomic biomarker: BCR-ABL [HSA:613 25], FIP1L1-PDGFRA [HSA:81608 5156], KIT [HSA:3815]
CYP inhibition: CYP3A [HSA:1576 1577 1551], CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antineoplastics - protein kinases inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XE Protein kinase inhibitors
     L01XE01 Imatinib
      D01441  Imatinib mesylate (USAN)
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Imatinib
    D01441  Imatinib mesylate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D01441  Imatinib mesylate (USAN); Imatinib mesilate (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    PDGFRA tyrosine kinase
     Imatinib
      D01441  Imatinib mesylate (USAN)
    PDGFRB tyrosine kinase
     Imatinib
      D01441  Imatinib mesylate (USAN)
    c-KIT tyrosine kinase
     Imatinib
      D01441  Imatinib mesylate (USAN)
 Protein kinases
  Tyrosine protein kinases
   Abl family
    Bcr-Abl tyrosine kinase
     Imatinib
      D01441  Imatinib mesylate (USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2D6
   Imatinib
    D01441  Imatinib mesylate (USAN)
  CYP3A
   Imatinib
    D01441  Imatinib mesylate (USAN)
 CYP substrates
  CYP2C9
   Imatinib
    D01441  Imatinib mesylate (USAN)
  CYP2D6
   Imatinib
    D01441  Imatinib mesylate (USAN)
  CYP3A4
   Imatinib
    D01441  Imatinib mesylate (USAN)
  CYP3A5
   Imatinib
    D01441  Imatinib mesylate (USAN)
 Transporter substrates
  ABCB1
   Imatinib
    D01441  Imatinib mesylate (USAN)
  ABCG2
   Imatinib
    D01441  Imatinib mesylate (USAN)
Antineoplastics [br08340.html]
 D01441
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D01441
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D01441
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Companion diagnostics
  D01441
BRITE hierarchy
Other DBs
CAS: 
220127-57-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        42
            1   C8x C    33.4600  -13.6500
            2   C8y C    33.4600  -12.2500
            3   C8x C    32.2700  -11.5500
            4   C8x C    31.0100  -12.2500
            5   C8y C    31.0100  -13.6500
            6   C8x C    32.2700  -14.3500
            7   C5a C    29.8200  -14.3500
            8   N1b N    28.6300  -13.6500
            9   C8y C    27.4400  -14.3500
            10  C8x C    26.1800  -13.6500
            11  C8y C    24.9900  -14.3500
            12  C8y C    24.9900  -15.7500
            13  C8x C    26.1800  -16.4500
            14  C8x C    27.4400  -15.7500
            15  N1b N    23.8000  -13.7200
            16  C8y C    22.5400  -14.4200
            17  N5x N    21.3500  -13.7200
            18  C8y C    20.1600  -14.4200
            19  C8x C    20.1600  -15.8200
            20  C8x C    21.3500  -16.5200
            21  N5x N    22.5400  -15.8200
            22  C8y C    18.9000  -13.7200
            23  C8x C    18.9000  -12.3200
            24  N5x N    17.7100  -11.6200
            25  C8x C    16.5200  -12.3200
            26  C8x C    16.5200  -13.7200
            27  C8x C    17.7100  -14.4200
            28  C1b C    34.6500  -11.5500
            29  N1y N    35.9100  -12.2500
            30  C1x C    35.9100  -13.6500
            31  C1x C    37.1000  -14.3500
            32  N1y N    38.2900  -13.6500
            33  C1x C    38.2900  -12.2500
            34  C1x C    37.1000  -11.5500
            35  C1a C    39.5500  -14.3500
            36  O5a O    29.8200  -15.7500
            37  C1a C    23.8000  -16.4500
            38  S4a S    34.9300  -16.5900
            39  O1d O    34.9300  -15.1900
            40  O1d O    34.9300  -17.9900
            41  C1a C    33.5300  -16.5900
            42  O1d O    36.3300  -16.5900
BOND        45
            1    18  19 2
            2    19  20 1
            3    20  21 2
            4    21  16 1
            5     3   4 2
            6    18  22 1
            7     4   5 1
            8     5   6 2
            9     6   1 1
            10    9  10 2
            11   10  11 1
            12   22  23 2
            13   23  24 1
            14   24  25 2
            15   25  26 1
            16   26  27 2
            17   27  22 1
            18   11  12 2
            19    2  28 1
            20   12  13 1
            21   28  29 1
            22   13  14 2
            23   14   9 1
            24   11  15 1
            25    5   7 1
            26   29  30 1
            27   30  31 1
            28   31  32 1
            29   32  33 1
            30   33  34 1
            31   34  29 1
            32   15  16 1
            33   32  35 1
            34    7  36 2
            35    7   8 1
            36   12  37 1
            37    1   2 2
            38    8   9 1
            39    2   3 1
            40   16  17 2
            41   17  18 1
            42   38  39 2
            43   38  40 2
            44   38  41 1
            45   38  42 1

» Japanese version   » Back

DBGET integrated database retrieval system