KEGG   DRUG: D01832Help
Entry
D01832                      Drug                                   

Name
Modafinil (JAN/USAN/INN);
Provigil (TN)
Product
  Generic
Formula
C15H15NO2S
Exact mass
273.0823
Mol weight
273.3501
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Analeptic [treatment of narcolepsy and hypersomnia]
Remark
Therapeutic category: 
ATC code: 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2C9 [HSA:1559], CYP2C19 [HSA:1557], CYP1A2 [HSA:1544], CYP2B6 [HSA:1555]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP induction: CYP1A2 [HSA:1544], CYP3A [HSA:1576 1577 1551]
CYP inhibition: CYP2C19 [HSA:1557]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA07 Modafinil
      D01832  Modafinil (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Sleep Disorder Agents
  Sleep Disorders, Other
   Modafinil
    D01832  Modafinil (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01832  Modafinil (JAN/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Modafinil
    D01832  Modafinil (JAN/USAN/INN)
  CYP2B6
   Modafinil
    D01832  Modafinil (JAN/USAN/INN)
  CYP2C9
   Modafinil
    D01832  Modafinil (JAN/USAN/INN)
  CYP2C19
   Modafinil
    D01832  Modafinil (JAN/USAN/INN)
  CYP3A4
   Modafinil
    D01832  Modafinil (JAN/USAN/INN)
 Inhbitors
  CYP2C19
   Modafinil
    D01832  Modafinil (JAN/USAN/INN)
 Inducers
  CYP1A2
   Modafinil
    D01832  Modafinil (JAN/USAN/INN)
  CYP3A
   Modafinil
    D01832  Modafinil (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
68693-11-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        19
            1   C8x C    21.4292  -18.4524
            2   C8x C    21.4292  -19.8539
            3   C8x C    22.6459  -20.5546
            4   C8x C    23.8554  -19.8539
            5   C8y C    23.8554  -18.4524
            6   C8x C    22.6459  -17.7516
            7   C1c C    25.0604  -17.7516
            8   C8y C    26.2708  -18.4524
            9   C8x C    26.2691  -19.8510
            10  C8x C    27.4794  -20.5517
            11  C8x C    28.6914  -19.8539
            12  C8x C    28.6931  -18.4552
            13  C8x C    27.4828  -17.7545
            14  S4a S    25.0590  -16.3501
            15  C1b C    26.2721  -15.6482
            16  O3c O    23.8447  -15.6505
            17  C5a C    26.2708  -14.2467
            18  N1a N    27.4839  -13.5447
            19  O5a O    25.0563  -13.5471
BOND        20
            1     4   5 1
            2     5   6 2
            3     6   1 1
            4     8   9 2
            5     9  10 1
            6    10  11 2
            7    11  12 1
            8    12  13 2
            9    13   8 1
            10    7  14 1
            11    5   7 1
            12   14  15 1
            13    1   2 2
            14   14  16 2
            15    7   8 1
            16   15  17 1
            17    2   3 1
            18   17  18 1
            19    3   4 2
            20   17  19 2

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