KEGG   DRUG: ModafinilHelp
Entry
D01832                      Drug                                   

Name
Modafinil (JAN/USAN/INN);
Provigil (TN)
Product
  Generic
Formula
C15H15NO2S
Exact mass
273.0823
Mol weight
273.3501
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cyp substrate
 DG01892  CYP1A2 substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A4 substrate
Cyp inducer
 DG01637  CYP1A2 inducer
 DG01635  CYP3A4 inducer
 DG01897  CYP3A5 inducer
Unclassified
 DG01933  CYP2C19 inhibitor
Remark
Therapeutic category: 
ATC code: 
Activity
Analeptic
Comment
Treatment of narcolepsy and hypersomnia
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2C9 [HSA:1559], CYP2C19 [HSA:1557], CYP1A2 [HSA:1544], CYP2B6 [HSA:1555]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP induction: CYP1A2 [HSA:1544], CYP2B6 [HSA:1555], CYP3A [HSA:1576 1577 1551]
CYP inhibition: CYP2C9 [HSA:1559], CYP2C19 [HSA:1557]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA07 Modafinil
      D01832  Modafinil (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Sleep Disorder Agents
  Sleep Disorders, Other
   Modafinil
    D01832  Modafinil (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01832  Modafinil (JAN/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2C19
   Modafinil
    D01832  Modafinil (JAN/USAN/INN)
 CYP inducers
  CYP1A2
   Modafinil
    D01832  Modafinil (JAN/USAN/INN)
  CYP3A
   Modafinil
    D01832  Modafinil (JAN/USAN/INN)
 CYP substrates
  CYP1A2
   Modafinil
    D01832  Modafinil (JAN/USAN/INN)
  CYP2B6
   Modafinil
    D01832  Modafinil (JAN/USAN/INN)
  CYP2C9
   Modafinil
    D01832  Modafinil (JAN/USAN/INN)
  CYP2C19
   Modafinil
    D01832  Modafinil (JAN/USAN/INN)
  CYP3A4
   Modafinil
    D01832  Modafinil (JAN/USAN/INN)
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D01832
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D01832
BRITE hierarchy
Other DBs
CAS: 
68693-11-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        19
            1   C8x C    21.4292  -18.4524
            2   C8x C    21.4292  -19.8539
            3   C8x C    22.6459  -20.5546
            4   C8x C    23.8554  -19.8539
            5   C8y C    23.8554  -18.4524
            6   C8x C    22.6459  -17.7516
            7   C1c C    25.0604  -17.7516
            8   C8y C    26.2708  -18.4524
            9   C8x C    26.2691  -19.8510
            10  C8x C    27.4794  -20.5517
            11  C8x C    28.6914  -19.8539
            12  C8x C    28.6931  -18.4552
            13  C8x C    27.4828  -17.7545
            14  S4a S    25.0590  -16.3501
            15  C1b C    26.2721  -15.6482
            16  O3c O    23.8447  -15.6505
            17  C5a C    26.2708  -14.2467
            18  N1a N    27.4839  -13.5447
            19  O5a O    25.0563  -13.5471
BOND        20
            1     4   5 1
            2     5   6 2
            3     6   1 1
            4     8   9 2
            5     9  10 1
            6    10  11 2
            7    11  12 1
            8    12  13 2
            9    13   8 1
            10    7  14 1
            11    5   7 1
            12   14  15 1
            13    1   2 2
            14   14  16 2
            15    7   8 1
            16   15  17 1
            17    2   3 1
            18   17  18 1
            19    3   4 2
            20   17  19 2

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