KEGG   DRUG: Mitiglinide calcium hydrate
Entry
D01854                      Drug                                   
Name
Mitiglinide calcium hydrate (JP18);
Mitiglinide calcium dihydrate;
Glufast (TN)
Formula
(C19H24NO3)2. 2H2O. Ca
Exact mass
704.335
Mol weight
704.9061
Structure
Simcomp
Class
Antidiabetic agent
 DG01508  Sulfonylurea receptor agonist
  DG01735  Glinide
 DG02044  Hypoglycemic agent
  DG01735  Glinide
Metabolizing enzyme substrate
 DG02924  UGT substrate
Remark
Therapeutic category: 3969
ATC code: A10BX08
Product: D01854<JP>
Product (mixture): D10160<JP>
Efficacy
Antidiabetic, Hypoglycemic, Sulfonylurea receptor agonist
Comment
Glinide derivative
Rapid-onset insulinotropic agents
Target
ABCC8(SUR1)/KCNJ11(KIR6.2) [HSA:6833 3767] [KO:K05032 K05004]
  Pathway
hsa02010  ABC transporters
hsa04911  Insulin secretion
hsa04930  Type II diabetes mellitus
Metabolism
Enzyme: UGT [KO:K00699]
Interaction
Structure map
map07051  Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BX Other blood glucose lowering drugs, excl. insulins
     A10BX08 Mitiglinide
      D01854  Mitiglinide calcium hydrate (JP18) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3969  Others
     D01854  Mitiglinide calcium hydrate (JP18)
Drug groups [BR:br08330]
 Antidiabetic agent
  DG01508  Sulfonylurea receptor agonist
   DG01735  Glinide
    D01854  Mitiglinide calcium hydrate
  DG02044  Hypoglycemic agent
   DG01735  Glinide
    D01854  Mitiglinide calcium hydrate
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   D01854  Mitiglinide calcium hydrate
Drug classes [BR:br08332]
 Antidiabetic agent
  DG01735  Glinide
   D01854  Mitiglinide calcium hydrate
  DG02044  Hypoglycemic agent
   D01854  Mitiglinide calcium hydrate
Target-based classification of drugs [BR:br08310]
 Transporters
  ABC transporters
   ABCC subfamily
    ABCC8(SUR1)/KCNJ11(KIR6.2)
     D01854  Mitiglinide calcium hydrate (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01854  Mitiglinide calcium hydrate
  D01854  Mitiglinide calcium tablets
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01854
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01854
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01854
Other DBs
PubChem: 7848916
LigandBox: D01854
LinkDB
KCF data

ATOM        49
            1   N1y N    14.7700  -17.2900
            2   C5a C    15.9600  -16.5900
            3   C1b C    17.1500  -17.2900
            4   C1c C    18.3400  -16.5900
            5   C6a C    19.6000  -17.2900
            6   O6a O    20.7900  -16.5900 #-
            7   C1x C    14.5600  -18.6900
            8   C1x C    13.4400  -16.7300
            9   C1y C    12.5300  -17.7800
            10  C1y C    13.2300  -18.9700
            11  C1x C    12.5300  -20.1600
            12  C1x C    11.1300  -20.1600
            13  C1x C    10.4300  -18.9700
            14  C1x C    11.1300  -17.7800
            15  O5a O    15.9600  -15.1900
            16  C1b C    18.4100  -15.1900
            17  O6a O    19.6000  -18.6900
            18  C8y C    19.6000  -14.4900
            19  C8x C    19.6000  -13.0900
            20  C8x C    20.7900  -12.3900
            21  C8x C    22.0500  -13.0900
            22  C8x C    22.0500  -14.4900
            23  C8x C    20.7900  -15.1900
            24  Z   Ca   25.3400  -14.4200 #2+
            25  O0  O    26.6700  -17.2200
            26  N1y N    14.7700  -17.2900
            27  C5a C    15.9600  -16.5900
            28  O5a O    15.9600  -15.1900
            29  C1b C    17.1500  -17.2900
            30  C1c C    18.3400  -16.5900
            31  C6a C    19.6000  -17.2900
            32  O6a O    20.7900  -16.5900 #-
            33  O6a O    19.6000  -18.6900
            34  C1b C    18.4100  -15.1900
            35  C8y C    19.6000  -14.4900
            36  C8x C    19.6000  -13.0900
            37  C8x C    20.7900  -12.3900
            38  C8x C    22.0500  -13.0900
            39  C8x C    22.0500  -14.4900
            40  C8x C    20.7900  -15.1900
            41  C1x C    14.5600  -18.6900
            42  C1y C    13.2300  -18.9700
            43  C1y C    12.5300  -17.7800
            44  C1x C    11.1300  -17.7800
            45  C1x C    10.4300  -18.9700
            46  C1x C    11.1300  -20.1600
            47  C1x C    12.5300  -20.1600
            48  C1x C    13.4400  -16.7300
            49  O0  O    26.6700  -17.2200
BOND        50
            1     4   5 1
            2     1   2 1
            3     5   6 1
            4     9  10 1
            5    10  11 1
            6    11  12 1
            7    12  13 1
            8    13  14 1
            9    14   9 1
            10    2  15 2
            11    2   3 1
            12    4  16 1 #Down
            13    1   7 1
            14    5  17 2
            15    7  10 1
            16   16  18 1
            17    9   8 1
            18    8   1 1
            19    3   4 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   23  18 1
            26   30  31 1
            27   26  27 1
            28   31  32 1
            29   43  42 1
            30   42  47 1
            31   47  46 1
            32   46  45 1
            33   45  44 1
            34   44  43 1
            35   27  28 2
            36   27  29 1
            37   30  34 1 #Down
            38   26  41 1
            39   31  33 2
            40   41  42 1
            41   34  35 1
            42   43  48 1
            43   48  26 1
            44   29  30 1
            45   35  36 2
            46   36  37 1
            47   37  38 2
            48   38  39 1
            49   39  40 2
            50   40  35 1
BRACKET     1     9.6600  -20.8600    9.6600  -11.4800
            1    22.7500  -11.4800   22.7500  -20.8600
            1  2
 ORIGINAL  1    1   2  15   3   4   5   6  17  16  18  19  20  21  22  23   7
            1   10  24   9  25  14  13  12  11   8
 REPEAT    1   28  29  30  31  32  33  34  35  36  37  38  39  40  41  42  43
            1   44  45  46  47  48  49  50  51  52
            2    24.4300  -18.2700   24.4300  -16.1700
            2    27.2300  -16.1700   27.2300  -18.2700
            2  2
 ORIGINAL  2   27
 REPEAT    2   53

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