KEGG   DRUG: Zoledronic acidHelp
Entry
D01968                      Drug                                   

Name
Zoledronic acid (USAN);
Zoledronic acid hydrate (JAN);
Zometa (TN)
Product
  Generic
ZOLEDRONIC ACID (Accord Healthcare), ZOLEDRONIC ACID (Actavis Pharma), ZOLEDRONIC ACID (Akorn), ZOLEDRONIC ACID (Akorn), ZOLEDRONIC ACID (Amneal-Agila), ZOLEDRONIC ACID (Apotex Corp), ZOLEDRONIC ACID (AuroMedics Pharma LLC), ZOLEDRONIC ACID (Breckenridge Pharmaceutical), ZOLEDRONIC ACID (Breckenridge Pharmaceutical), ZOLEDRONIC ACID (Dr. Reddy's Laboratories), ZOLEDRONIC ACID (Dr. Reddy's Laboratories Limited), ZOLEDRONIC ACID (Dr.Reddy's Laboratories), ZOLEDRONIC ACID (Dr.Reddy's Laboratories), ZOLEDRONIC ACID (Fresenius Kabi USA), ZOLEDRONIC ACID (Fresenius Kabi USA), ZOLEDRONIC ACID (Gland Pharma Limited), ZOLEDRONIC ACID (Gland Pharma Limited), ZOLEDRONIC ACID (Heritage Pharmaceuticals), ZOLEDRONIC ACID (Heritage Pharmaceuticals), ZOLEDRONIC ACID (Heritage Pharmaceuticals), ZOLEDRONIC ACID (Hospira), ZOLEDRONIC ACID (Hospira), ZOLEDRONIC ACID (JHP Pharmaceuticals), ZOLEDRONIC ACID (Mylan Institutional LLC), ZOLEDRONIC ACID (Mylan Institutional LLC), ZOLEDRONIC ACID (Par Pharmaceutical Companies), ZOLEDRONIC ACID (Par Pharmaceutical Companies), ZOLEDRONIC ACID (Sagent Pharmaceuticals), ZOLEDRONIC ACID (Sagent Pharmaceuticals), ZOLEDRONIC ACID (Sagent Pharmaceuticals), ZOLEDRONIC ACID (West-Ward Pharmaceuticals Corp)
Formula
C5H10N2O7P2. H2O
Exact mass
290.0069
Mol weight
290.1049
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Other
 DG01600  Bisphosphonate
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Efficacy
Antihypercalcemia, Antiresorptive, Farnesylpyrophosphate synthetase inhibitor
  Disease
Osteoporosis [DS:H01593]
Glucocorticoid-induced osteoporosis [DS:H01709]
Paget's disease of bone [DS:H00437]
Comment
Bisphosphonate
Target
FDPS [HSA:2224] [KO:K00787]
  Pathway
Terpenoid backbone biosynthesis
Interaction
Drug interaction
Structure map
Osteoporosis drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M05 DRUGS FOR TREATMENT OF BONE DISEASES
   M05B DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
    M05BA Bisphosphonates
     M05BA08 Zoledronic acid
      D01968  Zoledronic acid (USAN)
USP drug classification [BR:br08302]
 Metabolic Bone Disease Agents
  Zoledronic acid
   D01968  Zoledronic acid (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D01968  Zoledronic acid (USAN); Zoledronic acid hydrate (JAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases
   farnesylpyrophosphate synthetase
    Zoledronic acid
     D01968  Zoledronic acid (USAN)
Antineoplastics [br08340.html]
 D01968
Osteoporosis drugs [br08368.html]
 D01968
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D01968
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01968
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01968
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01968
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D01968
BRITE hierarchy
Other DBs
CAS: 
165800-06-6
PubChem: 
DrugBank: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        17
            1   O0  O    28.8400  -25.1300
            2   C1d C    23.3100  -23.8000
            3   P1b P    24.5700  -24.4300
            4   P1b P    22.1200  -24.4300
            5   C1b C    23.3100  -22.4000
            6   O1c O    20.9300  -23.8000
            7   O1c O    22.1200  -25.8300
            8   O1c O    20.5800  -25.4100
            9   O1c O    25.6900  -23.8000
            10  O1c O    24.5700  -25.8300
            11  O1c O    25.6900  -25.1300
            12  O1a O    23.3100  -25.2000
            13  N4y N    24.5000  -21.7000
            14  C8x C    25.8300  -22.1200
            15  N5x N    26.6700  -21.0000
            16  C8x C    25.8300  -19.8800
            17  C8x C    24.5000  -20.3000
BOND        16
            1     2   3 1
            2     2   4 1
            3     2   5 1
            4     4   6 2
            5     4   7 1
            6     4   8 1
            7     3   9 2
            8     3  10 1
            9     3  11 1
            10    2  12 1
            11    5  13 1
            12   13  14 1
            13   14  15 2
            14   15  16 1
            15   16  17 2
            16   13  17 1

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