KEGG   DRUG: D02103Help
Entry
D02103                      Drug                                   

Name
Phenytoin sodium for injection (JP16);
Phenytoin sodium (USP);
Aleviatin (TN);
Dilantin (TN)
Product
  Generic
DILANTIN (REMEDYREPACK), PHENYTEK (Mylan Pharmaceuticals), EXTENDED PHENYTOIN SODIUM (PD-Rx Pharmaceuticals), EXTENDED PHENYTOIN SODIUM (REMEDYREPACK), EXTENDED PHENYTOIN SODIUM (REMEDYREPACK), EXTENDED PHENYTOIN SODIUM (REMEDYREPACK), EXTENDED PHENYTOIN SODIUM (Wockhardt Limited), EXTENDED PHENYTOIN SODIUM (Wockhardt USA LLC.), DILANTIN (A-S Medication Solutions LLC), EXTENDED PHENYTOIN SODIUM (American Health Packaging), EXTENDED PHENYTOIN SODIUM (Amneal Pharmaceuticals of New York), DILANTIN (Aphena Pharma Solutions - Tennessee), PHENYTOIN SODIUM (AvPAK), PHENYTOIN SODIUM (Bryant Ranch Prepack), PHENYTOIN SODIUM (Cardinal Health), PHENYTOIN SODIUM (Cardinal Health), PHENYTOIN SODIUM (Cardinal Health), PHENYTOIN SODIUM (Cardinal Health), PHENYTOIN SODIUM (Cardinal Health), DILANTIN (Cardinal Health), DILANTIN (Carilion Materials Management), PHENYTOIN SODIUM (Clinical Solutions Wholesale), PHENYTEK (Clinical Solutions Wholesale), PHENYTOIN SODIUM (Contract Pharmacy Services-PA), PHENYTOIN SODIUM (General Injectables & Vaccines), PHENYTOIN SODIUM (General Injectables & Vaccines), PHENYTOIN SODIUM (General Injectables & Vaccines), PHENYTOIN SODIUM (General Injectables & Vaccines), PHENYTOIN SODIUM (General Injectables & Vaccines), PHENYTOIN SODIUM (Hospira), PHENYTOIN SODIUM (Hospira), DILANTIN (KAISER FOUNDATION HOSPITALS), PHENYTOIN SODIUM (Lake Erie Medical DBA Quality Care Products LLC), EXTENDED PHENYTOIN SODIUM (Major Pharmaceuticals), PHENYTOIN SODIUM (McKesson Contract Packaging), PHENYTOIN SODIUM (Mylan Institutional), PHENYTOIN SODIUM (Mylan Pharmaceuticals), PHENYTOIN SODIUM (NCS HealthCare of KY), EXTENDED PHENYTOIN SODIUM (PD-Rx Pharmaceuticals), DILANTIN (Parke-Davis Div of Pfizer), DILANTIN (Physicians Total Care), PHENYTOIN SODIUM (Physicians Total Care), EXTENDED PHENYTOIN SODIUM (REMEDYREPACK), DILANTIN (REMEDYREPACK), DILANTIN (REMEDYREPACK), PHENYTOIN SODIUM (REMEDYREPACK), PHENYTOIN SODIUM (REMEDYREPACK), EXTENDED PHENYTOIN SODIUM (REMEDYREPACK), PHENYTOIN SODIUM (Rebel Distributors Corp), PHENYTOIN (STAT RX USA LLC), PHENYTOIN SODIUM (SUN PHARMACEUTICAL INDUSTRIES LIMITED), PHENYTOIN SODIUM (State of Florida DOH Central Pharmacy), PHENYTOIN SODIUM (Sun Pharmaceutical Industries Limited), PHENYTOIN SODIUM (Taro Pharmaceuticals U.S.A.), PHENYTOIN SODIUM (Upsher-Smith Laboratories), PHENYTOIN SODIUM (West-Ward Pharmaceutical Corp.), PHENYTOIN SODIUM (West-Ward Pharmaceutical Corp.), PHENYTOIN SODIUM (X-GEN Pharmaceuticals)
Formula
C15H11N2O2. Na
Exact mass
274.0718
Mol weight
274.2498
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticonvulsant [DS:H00808]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Hydantoins
There is a strong association between the risk of developing SJS/TEN with Phenytoin treatment and the presence of an inherited variant of the HLA-B gene, HLA-B*1502.
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP2C19 [HSA:1557], CYP3A [HSA:1576 1577 1551], CYP2B6 [HSA:1555]
Interaction
Genomic biomarker: HLA-B [HSA:3106]
CYP induction: CYP3A [HSA:1576 1577 1551], CYP1A2 [HSA:1544]
Transporter induction: ABCB1 [HSA:5243]
Drug interaction
Structure map
Anticonvulsants
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AB Hydantoin derivatives
     N03AB02 Phenytoin
      D02103  Phenytoin sodium for injection (JP16); Phenytoin sodium (USP)
USP drug classification [BR:br08302]
 Anticonvulsants
  Sodium Channel Agents
   Phenytoin
    D02103  Phenytoin sodium for injection (JP16); Phenytoin sodium (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1132  Hydantoins
     D02103  Phenytoin sodium for injection (JP16); Phenytoin sodium (USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Phenytoin
      D02103  Phenytoin sodium (USP)
    voltage-gated sodium channel (SCN2A)
     Phenytoin
      D02103  Phenytoin sodium (USP)
    voltage-gated sodium channel (SCN3A)
     Phenytoin
      D02103  Phenytoin sodium (USP)
    voltage-gated sodium channel (SCN4A)
     Phenytoin
      D02103  Phenytoin sodium (USP)
    voltage-gated sodium channel (SCN5A)
     Phenytoin
      D02103  Phenytoin sodium (USP)
    voltage-gated sodium channel (SCN8A)
     Phenytoin
      D02103  Phenytoin sodium (USP)
    voltage-gated sodium channel (SCN9A)
     Phenytoin
      D02103  Phenytoin sodium (USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2B6
   Phenytoin
    D02103  Phenytoin sodium for injection (JP16); Phenytoin sodium (USP)
  CYP2C9
   Phenytoin
    D02103  Phenytoin sodium for injection (JP16); Phenytoin sodium (USP)
  CYP2C19
   Phenytoin
    D02103  Phenytoin sodium for injection (JP16); Phenytoin sodium (USP)
  CYP3A
   Phenytoin
    D02103  Phenytoin sodium for injection (JP16); Phenytoin sodium (USP)
 Inducers
  CYP1A2
   Phenytoin
    D02103  Phenytoin sodium for injection (JP16); Phenytoin sodium (USP)
  CYP3A
   Phenytoin
    D02103  Phenytoin sodium for injection (JP16); Phenytoin sodium (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02103  Phenytoin sodium for injection
BRITE hierarchy
Other DBs
CAS: 
630-93-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        20
            1   Z   Na   16.6434  -17.9173 #+
            2   C1z C    14.9800  -21.4200
            3   N1x N    15.4700  -20.1600
            4   C2y C    14.3500  -19.3900
            5   N2x N    13.1600  -20.1600
            6   C5x C    13.6500  -21.4200
            7   O1a O    14.3500  -17.9200 #-
            8   O5x O    12.8100  -22.6100
            9   C8y C    16.3800  -21.4200
            10  C8x C    17.0800  -22.6800
            11  C8x C    18.5500  -22.6800
            12  C8x C    19.2500  -21.4900
            13  C8x C    18.4800  -20.2300
            14  C8x C    17.0800  -20.2300
            15  C8y C    14.9800  -22.8900
            16  C8x C    13.7900  -23.5200
            17  C8x C    13.7900  -24.9200
            18  C8x C    15.0500  -25.6900
            19  C8x C    16.2400  -24.9900
            20  C8x C    16.2400  -23.5900
BOND        21
            1     2   3 1
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     2   6 1
            6     4   7 1
            7     6   8 2
            8     2   9 1
            9     9  10 2
            10   10  11 1
            11   11  12 2
            12   12  13 1
            13   13  14 2
            14    9  14 1
            15    2  15 1
            16   15  16 2
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   19  20 2
            21   15  20 1

» Japanese version   » Back

DBGET integrated database retrieval system