KEGG   DRUG: D02138Help
Entry
D02138                      Drug                                   

Name
Colistin sulfate (JP16/USP);
Coly-Mycin S;
Colymycin S (TN)
Formula
(C52H97N16O13R)2. 5H2SO4
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
Same as: 
ATC code: 
Drug group: 
Comment
Colistin A (R = -CH3)
Colistin B (R = -H)
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07A INTESTINAL ANTIINFECTIVES
    A07AA Antibiotics
     A07AA10 Colistin
      D02138  Colistin sulfate (JP16/USP)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01X OTHER ANTIBACTERIALS
    J01XB Polymyxins
     J01XB01 Colistin
      D02138  Colistin sulfate (JP16/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  56 Purulent skin remedies
   D02138  Colistin sulfate (JP16/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Colistin
    D02138  Colistin sulfate (JP16/USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Others
   Cell membrane function inhibitors
    Polypeptides
     Colistin
      D02138  Colistin sulfate (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02138  Colistin sulfate
BRITE hierarchy
Other DBs
CAS: 
1264-72-8
PubChem: 
DrugBank: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        189
            1   S4a S    43.7884  -14.0613
            2   O1d O    43.7884  -15.4667
            3   O1d O    45.1939  -14.0613
            4   O1d O    43.7884  -12.6557
            5   O1d O    42.3830  -14.0613
            6   C1c C    29.0933  -19.7038
            7   C1a C    30.3008  -20.4028
            8   O1a O    27.8786  -20.4028
            9   C1c C    25.4494  -11.7267
            10  N1b N    25.4494  -13.1319
            11  N1b N    27.8786  -11.7267
            12  C5a C    26.6711  -11.0275
            13  C5a C    30.3008  -11.7267
            14  C1c C    29.0933  -11.0275
            15  C1c C    32.7300  -11.7267
            16  N1b N    31.5153  -11.0275
            17  C5a C    24.2419  -13.8239
            18  C1c C    24.2419  -15.2222
            19  C1b C    25.4494  -15.9281
            20  C1b C    25.4494  -17.3264
            21  N1b N    26.6711  -18.0184
            22  C5a C    27.8786  -17.3264
            23  C1c C    29.0933  -18.0184
            24  N1b N    30.3008  -17.3264
            25  C5a C    31.5153  -18.0184
            26  C1c C    32.7300  -17.3264
            27  O5a O    26.6711   -9.6294
            28  C1c C    35.1522  -11.7267
            29  C1b C    33.9376  -11.0275
            30  C1b C    29.0933   -9.3494
            31  C5a C    32.7300  -13.1319
            32  C1a C    36.3666  -11.0275
            33  C1a C    35.1522  -13.1319
            34  O5a O    31.5153  -13.8239
            35  C1c C    30.3008   -8.6503
            36  C1a C    31.5648   -9.3494
            37  C1a C    30.3008   -7.2098
            38  O5a O    30.3008  -13.1319
            39  C1b C    24.2419  -11.0275
            40  O5a O    23.0274  -13.1319
            41  N1b N    23.0274  -15.9281
            42  O5a O    27.8786  -15.9281
            43  O5a O    31.5153  -19.4238
            44  N1b N    32.7300  -15.9281
            45  C5a C    34.1281  -15.9281
            46  N1b N    33.9376  -13.8239
            47  C1c C    34.8271  -14.7560
            48  C1b C    36.2253  -14.7560
            49  C1b C    33.9376  -18.0184
            50  C1b C    33.9376  -19.4238
            51  N1a N    35.1522  -20.1228
            52  C1b C    24.2419   -9.6294
            53  N1a N    23.0274   -8.9303
            54  C5a C    21.8198  -15.2222
            55  C1c C    20.6053  -15.9281
            56  N1b N    19.3978  -15.2222
            57  C5a C    18.1831  -15.9281
            58  C1c C    16.9615  -15.2222
            59  N1b N    15.7541  -15.9281
            60  C5a C    14.5394  -15.2222
            61  C1c C    13.3319  -15.9281
            62  N1b N    12.1172  -15.2222
            63  C5a C    10.9098  -15.9281
            64  C1b C     9.6951  -15.2222
            65  C1b C     8.4876  -15.9281
            66  C1b C     7.2660  -15.2222
            67  C1b C     6.0515  -15.9281
            68  C1c C     4.8439  -15.2222
            69  C1b C     3.6292  -15.9281
            70  R   R     2.4217  -15.2222
            71  O5a O    21.8198  -13.8239
            72  C1b C    20.6053  -17.3264
            73  O5a O    18.1831  -17.3264
            74  C1c C    16.9615  -13.4739
            75  C1a C    15.7541  -12.7819
            76  O1a O    18.1831  -12.7819
            77  O5a O    14.5394  -13.8239
            78  C1b C    13.3319  -17.3264
            79  O5a O    10.9098  -17.3264
            80  C1a C     4.8439  -13.8239
            81  C1b C    19.3978  -18.0184
            82  N1a N    19.3978  -19.4238
            83  C1b C    12.1172  -18.0184
            84  N1a N    12.1172  -19.4238
            85  O5a O    34.8271  -17.1357
            86  C1b C    36.9404  -15.9936
            87  N1a N    38.3596  -15.9936
            88  S4a S    43.7884  -14.0613
            89  O1d O    43.7884  -15.4667
            90  O1d O    45.1939  -14.0613
            91  O1d O    43.7884  -12.6557
            92  O1d O    42.3830  -14.0613
            93  S4a S    43.7884  -14.0613
            94  O1d O    43.7884  -15.4667
            95  O1d O    45.1939  -14.0613
            96  O1d O    43.7884  -12.6557
            97  O1d O    42.3830  -14.0613
            98  S4a S    43.7884  -14.0613
            99  O1d O    43.7884  -15.4667
            100 O1d O    45.1939  -14.0613
            101 O1d O    43.7884  -12.6557
            102 O1d O    42.3830  -14.0613
            103 S4a S    43.7884  -14.0613
            104 O1d O    43.7884  -15.4667
            105 O1d O    45.1939  -14.0613
            106 O1d O    43.7884  -12.6557
            107 O1d O    42.3830  -14.0613
            108 C1c C    29.0933  -19.7038
            109 C1a C    30.3008  -20.4028
            110 O1a O    27.8786  -20.4028
            111 C1c C    29.0933  -18.0184
            112 C5a C    27.8786  -17.3264
            113 O5a O    27.8786  -15.9281
            114 N1b N    26.6711  -18.0184
            115 C1b C    25.4494  -17.3264
            116 C1b C    25.4494  -15.9281
            117 C1c C    24.2419  -15.2222
            118 N1b N    23.0274  -15.9281
            119 C5a C    21.8198  -15.2222
            120 C1c C    20.6053  -15.9281
            121 N1b N    19.3978  -15.2222
            122 C5a C    18.1831  -15.9281
            123 C1c C    16.9615  -15.2222
            124 N1b N    15.7541  -15.9281
            125 C5a C    14.5394  -15.2222
            126 C1c C    13.3319  -15.9281
            127 N1b N    12.1172  -15.2222
            128 C5a C    10.9098  -15.9281
            129 C1b C     9.6951  -15.2222
            130 C1b C     8.4876  -15.9281
            131 C1b C     7.2660  -15.2222
            132 C1b C     6.0515  -15.9281
            133 C1c C     4.8439  -15.2222
            134 C1b C     3.6292  -15.9281
            135 R   R     2.4217  -15.2222
            136 C1a C     4.8439  -13.8239
            137 O5a O    10.9098  -17.3264
            138 C1b C    13.3319  -17.3264
            139 C1b C    12.1172  -18.0184
            140 N1a N    12.1172  -19.4238
            141 O5a O    14.5394  -13.8239
            142 C1c C    16.9615  -13.4739
            143 C1a C    15.7541  -12.7819
            144 O1a O    18.1831  -12.7819
            145 O5a O    18.1831  -17.3264
            146 C1b C    20.6053  -17.3264
            147 C1b C    19.3978  -18.0184
            148 N1a N    19.3978  -19.4238
            149 O5a O    21.8198  -13.8239
            150 C5a C    24.2419  -13.8239
            151 O5a O    23.0274  -13.1319
            152 N1b N    25.4494  -13.1319
            153 C1c C    25.4494  -11.7267
            154 C1b C    24.2419  -11.0275
            155 C1b C    24.2419   -9.6294
            156 N1a N    23.0274   -8.9303
            157 C5a C    26.6711  -11.0275
            158 O5a O    26.6711   -9.6294
            159 N1b N    27.8786  -11.7267
            160 C1c C    29.0933  -11.0275
            161 C1b C    29.0933   -9.3494
            162 C1c C    30.3008   -8.6503
            163 C1a C    31.5648   -9.3494
            164 C1a C    30.3008   -7.2098
            165 C5a C    30.3008  -11.7267
            166 O5a O    30.3008  -13.1319
            167 N1b N    31.5153  -11.0275
            168 C1c C    32.7300  -11.7267
            169 C1b C    33.9376  -11.0275
            170 C1c C    35.1522  -11.7267
            171 C1a C    36.3666  -11.0275
            172 C1a C    35.1522  -13.1319
            173 C5a C    32.7300  -13.1319
            174 O5a O    31.5153  -13.8239
            175 N1b N    33.9376  -13.8239
            176 C1c C    34.8271  -14.7560
            177 C5a C    34.1281  -15.9281
            178 N1b N    32.7300  -15.9281
            179 C1c C    32.7300  -17.3264
            180 C5a C    31.5153  -18.0184
            181 N1b N    30.3008  -17.3264
            182 O5a O    31.5153  -19.4238
            183 C1b C    33.9376  -18.0184
            184 C1b C    33.9376  -19.4238
            185 N1a N    35.1522  -20.1228
            186 O5a O    34.8271  -17.1357
            187 C1b C    36.2253  -14.7560
            188 C1b C    36.9404  -15.9936
            189 N1a N    38.3596  -15.9936
BOND        184
            1     1   2 2
            2     1   3 1
            3     1   4 2
            4     1   5 1
            5    88  89 2
            6    88  90 1
            7    88  91 2
            8    88  92 1
            9    93  94 2
            10   93  95 1
            11   93  96 2
            12   93  97 1
            13   98  99 2
            14   98 100 1
            15   98 101 2
            16   98 102 1
            17  103 104 2
            18  103 105 1
            19  103 106 2
            20  103 107 1
            21    6   7 1
            22    6   8 1
            23   22  23 1
            24   23  24 1
            25   24  25 1
            26   25  26 1
            27   12  27 2
            28   28  29 1
            29   15  29 1
            30   14  30 1
            31   15  31 1
            32   28  32 1
            33   28  33 1
            34   31  34 2
            35   30  35 1
            36   35  36 1
            37   35  37 1
            38   13  38 2
            39    9  39 1
            40   17  40 2
            41   18  41 1
            42   22  42 2
            43   25  43 2
            44   26  44 1
            45   44  45 1
            46   31  46 1
            47   45  47 1
            48   46  47 1
            49   47  48 1
            50   26  49 1
            51   49  50 1
            52   50  51 1
            53   39  52 1
            54   52  53 1
            55   41  54 1
            56   54  55 1
            57   55  56 1
            58   56  57 1
            59   57  58 1
            60   58  59 1
            61   59  60 1
            62   60  61 1
            63   61  62 1
            64   62  63 1
            65   63  64 1
            66   64  65 1
            67   65  66 1
            68   66  67 1
            69   67  68 1
            70   68  69 1
            71   69  70 1
            72   54  71 2
            73   55  72 1
            74   57  73 2
            75   58  74 1
            76   74  75 1
            77   74  76 1
            78   60  77 2
            79   61  78 1
            80   63  79 2
            81   68  80 1
            82   72  81 1
            83   81  82 1
            84   78  83 1
            85   83  84 1
            86   45  85 2
            87    9  10 1
            88   11  12 1
            89    9  12 1
            90   13  14 1
            91   11  14 1
            92   15  16 1
            93   13  16 1
            94   10  17 1
            95   17  18 1
            96   18  19 1
            97   19  20 1
            98   20  21 1
            99   21  22 1
            100   6  23 1
            101  48  86 1
            102  86  87 1
            103 108 109 1
            104 108 110 1
            105 112 111 1
            106 111 181 1
            107 181 180 1
            108 180 179 1
            109 157 158 2
            110 170 169 1
            111 168 169 1
            112 160 161 1
            113 168 173 1
            114 170 171 1
            115 170 172 1
            116 173 174 2
            117 161 162 1
            118 162 163 1
            119 162 164 1
            120 165 166 2
            121 153 154 1
            122 150 151 2
            123 117 118 1
            124 112 113 2
            125 180 182 2
            126 179 178 1
            127 178 177 1
            128 173 175 1
            129 177 176 1
            130 175 176 1
            131 176 187 1
            132 179 183 1
            133 183 184 1
            134 184 185 1
            135 154 155 1
            136 155 156 1
            137 118 119 1
            138 119 120 1
            139 120 121 1
            140 121 122 1
            141 122 123 1
            142 123 124 1
            143 124 125 1
            144 125 126 1
            145 126 127 1
            146 127 128 1
            147 128 129 1
            148 129 130 1
            149 130 131 1
            150 131 132 1
            151 132 133 1
            152 133 134 1
            153 134 135 1
            154 119 149 2
            155 120 146 1
            156 122 145 2
            157 123 142 1
            158 142 143 1
            159 142 144 1
            160 125 141 2
            161 126 138 1
            162 128 137 2
            163 133 136 1
            164 146 147 1
            165 147 148 1
            166 138 139 1
            167 139 140 1
            168 177 186 2
            169 153 152 1
            170 159 157 1
            171 153 157 1
            172 165 160 1
            173 159 160 1
            174 168 167 1
            175 165 167 1
            176 152 150 1
            177 150 117 1
            178 117 116 1
            179 116 115 1
            180 115 114 1
            181 114 112 1
            182 108 111 1
            183 187 188 1
            184 188 189 1
BRACKET     1    41.1600  -16.4500   41.1600  -11.5500
            1    46.3400  -11.4800   46.3400  -16.3800
            1  5
 ORIGINAL  1    1   2   3   4   5
 REPEAT    1   88  89  90  91  92  93  94  95  96  97  98  99 100 101 102 103
            1  104 105 106 107
            2     2.2400  -21.1400    2.2400   -6.3700
            2    39.7600   -6.3700   39.7600  -21.1400
            2  2
 ORIGINAL  2    6   7   8  23  22  42  21  20  19  18  41  54  55  56  57  58
            2   59  60  61  62  63  64  65  66  67  68  69  70  80  79  78  83
            2   84  77  74  75  76  73  72  81  82  71  17  40  10   9  39  52
            2   53  12  27  11  14  30  35  36  37  13  38  16  15  29  28  32
            2   33  31  34  46  47  45  44  26  25  24  43  49  50  51  85  48
            2   86  87
 REPEAT    2  108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123
            2  124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139
            2  140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155
            2  156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171
            2  172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187
            2  188 189

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