KEGG   DRUG: D02173Help
Entry
D02173                      Drug                                   

Name
Galantamine hydrobromide (JAN/USAN);
Razadyne (TN);
Reminyl (TN)
Product
  Generic
Formula
C17H21NO3. HBr
Exact mass
367.0783
Mol weight
368.2655
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Alzheimer's disease treatment [cholinesterase inhibitor] [DS:H00056]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
acetylcholinesterase (AChE) inhibitor [HSA:43] [KO:K01049];
nicotinic acetylcholine receptor (nAChR) allosteric site agonist
  Pathway
hsa00564  Glycerophospholipid metabolism
hsa04725  Cholinergic synapse  
 
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Agents for Alzheimer-type dementia
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DA Anticholinesterases
     N06DA04 Galantamine
      D02173  Galantamine hydrobromide (JAN/USAN)
USP drug classification [BR:br08302]
 Antidementia Agents
  Cholinesterase Inhibitors
   Galantamine
    D02173  Galantamine hydrobromide (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D02173  Galantamine hydrobromide (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   acetylcholinesterase (AChE)
    Galantamine
     D02173  Galantamine hydrobromide (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
1953-04-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        22
            1   X   Br   26.7123  -22.0590
            2   C8y C    21.3562  -22.9628
            3   C1x C    22.4064  -23.7330
            4   N1y N    23.7367  -23.4529
            5   C1x C    24.2969  -22.1927
            6   C8y C    21.3562  -21.5625
            7   C1x C    23.7367  -21.0024
            8   C1z C    22.4064  -20.5123
            9   C1a C    24.6470  -24.5032
            10  C8x C    20.1659  -23.6630
            11  C8x C    18.9756  -22.9628
            12  C8y C    18.9756  -21.5625
            13  C8y C    20.1659  -20.8623
            14  O2a O    17.7854  -20.9324
            15  O2x O    20.5160  -19.2520
            16  C1y C    21.9163  -19.1820
            17  C1x C    22.5465  -18.0617
            18  C1y C    23.9468  -18.0617
            19  C2x C    24.6470  -19.2520
            20  C2x C    23.9468  -20.5123
            21  O1a O    24.6470  -16.8014
            22  C1a C    16.5992  -21.6765
BOND        24
            1     4   5 1
            2     2   6 2
            3     5   7 1
            4     3   4 1
            5     6   8 1
            6     2   3 1
            7     8   7 1 #Down
            8     4   9 1
            9     2  10 1
            10   10  11 2
            11   11  12 1
            12   12  13 2
            13    6  13 1
            14   12  14 1
            15   13  15 1
            16   15  16 1
            17    8  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21    8  20 1
            22   20  19 2
            23   18  21 1 #Up
            24   14  22 1

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