KEGG   DRUG: D02219Help
Entry
D02219                      Drug                                   

Name
Terbinafine hydrochloride (JP16/USP);
Lamisil (TN)
Product
  Generic
TERBINAFINE HYDROCHLORIDE (American Health Packaging), TERBINAFINE HYDROCHLORIDE (Camber Pharmaceuticals), TERBINAFINE HYDROCHLORIDE (Carilion Materials Management), TERBINAFINE (Exelan Pharmaceuticals), TERBINAFINE (HARRIS Pharmaceutical), TERBINAFINE HYDROCHLORIDE (Proficient Rx LP), TERBINAFINE HYDROCHLORIDE (REMEDYREPACK), TERBINAFINE (Aurobindo Pharma Limited), TERBINAFINE HYDROCHLORIDE (AvKARE), TERBINAFINE HYDROCHLORIDE (Breckenridge Pharmaceutical), TERBINAFINE HYDROCHLORIDE (Bryant Ranch Prepack), TERBINAFINE HYDROCHLORIDE (Dr.Reddys Laboratories Limited), TERBINAFINE HYDROCHLORIDE (Golden State Medical Supply), TERBINAFINE HYDROCHLORIDE (Harris Pharmaceutical), TERBINEX (Innocutis), TERBINAFINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), TERBINAFINE HYDROCHLORIDE (Northstar Rx LLC), TERBINAFINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), TERBINAFINE HYDOCHLORIDE (Physicians Total Care), TERBINAFINE HYDROCHLORIDE (Preferred Pharmaceuticals), TERBINAFINE HYDROCHLORIDE (Rebel Distributors Corp), TERBINAFINE HYDROCHLORIDE (Wockhardt Limited), TERBINAFINE HYDROCHLORIDE (Wockhardt USA LLC.), TERBINAFINE HYDROCHLORIDE (Wockhardt USA)
Formula
C21H25N. HCl
Exact mass
327.1754
Mol weight
327.8908
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antifungal [DS:H01316]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
squalene epoxidase inhibitor [KO:K00511]
  Pathway
ko00100  Steroid biosynthesis  
 
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP1A2 [HSA:1544], CYP3A4 [HSA:1576], CYP2C8 [HSA:1558], CYP2C19 [HSA:1557]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP2D6 [HSA:1565], CYP1A2 [HSA:1544]
Drug interaction
Structure map
Antifungal agents
Naphthalene family
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D01 ANTIFUNGALS FOR DERMATOLOGICAL USE
   D01A ANTIFUNGALS FOR TOPICAL USE
    D01AE Other antifungals for topical use
     D01AE15 Terbinafine
      D02219  Terbinafine hydrochloride (JP16/USP)
   D01B ANTIFUNGALS FOR SYSTEMIC USE
    D01BA Antifungals for systemic use
     D01BA02 Terbinafine
      D02219  Terbinafine hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Antifungals
  Terbinafine
   D02219  Terbinafine hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   265  Antiparasitic dermatosis agents
    2659  Others
     D02219  Terbinafine hydrochloride (JP16/USP)
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   629  Miscellaneous
    6290  Miscellaneous
     D02219  Terbinafine hydrochloride (JP16/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  58 Ringworm drugs
   D02219  Terbinafine hydrochloride (JP16/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Terbinafine
    D02219  Terbinafine hydrochloride (JP16/USP)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Terbinafine
    D02219  Terbinafine hydrochloride (JP16/USP)
Antiinfectives [BR:br08307]
 Antifungals
  Ergosterol biosynthesis inhibitor
   squalene epoxidase inhibitor
    Allylamines
     Terbinafine
      D02219  Terbinafine hydrochloride (JP16/USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Terbinafine
    D02219  Terbinafine hydrochloride (JP16/USP)
  CYP2C8
   Terbinafine
    D02219  Terbinafine hydrochloride (JP16/USP)
  CYP2C9
   Terbinafine
    D02219  Terbinafine hydrochloride (JP16/USP)
  CYP2C19
   Terbinafine
    D02219  Terbinafine hydrochloride (JP16/USP)
  CYP3A4
   Terbinafine
    D02219  Terbinafine hydrochloride (JP16/USP)
 Inhbitors
  CYP1A2
   Terbinafine
    D02219  Terbinafine hydrochloride (JP16/USP)
   Terbinafine
    D02219  Terbinafine hydrochloride (JP16/USP)
  CYP2D6
   Terbinafine
    D02219  Terbinafine hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02219  Terbinafine hydrochloride
  D02219  Terbinafine hydrochloride solution
  D02219  Terbinafine hydrochloride cream
  D02219  Terbinafine hydrochloride spray
BRITE hierarchy
Other DBs
CAS: 
78628-80-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        23
            1   X   Cl   36.1001  -19.8424
            2   C8x C    25.4100  -18.8300
            3   C8x C    25.4100  -20.2300
            4   C8x C    26.6700  -20.9300
            5   C8y C    27.8600  -20.2300
            6   C8y C    27.8600  -18.8300
            7   C8x C    26.6700  -18.1300
            8   C8x C    29.0500  -20.9300
            9   C8x C    30.3100  -20.2300
            10  C8x C    30.3100  -18.8300
            11  C8y C    29.0500  -18.1300
            12  C1b C    29.0500  -16.7300
            13  N1c N    30.3100  -16.0300
            14  C1b C    31.5000  -16.7300
            15  C1a C    30.3100  -14.6300
            16  C2b C    32.6900  -16.0300
            17  C2b C    33.8800  -16.7300
            18  C3b C    35.0700  -16.0300
            19  C3b C    36.2600  -15.3300
            20  C1d C    37.5200  -14.6300
            21  C1a C    38.7100  -13.9300
            22  C1a C    36.8200  -13.3700
            23  C1a C    38.2200  -15.8200
BOND        23
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     5   8 1
            8     8   9 2
            9     9  10 1
            10   10  11 2
            11    6  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   13  15 1
            16   14  16 1
            17   16  17 2
            18   17  18 1
            19   18  19 3
            20   19  20 1
            21   20  21 1
            22   20  22 1
            23   20  23 1

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