KEGG   DRUG: D02260Help
Entry
D02260                      Drug                                   

Name
Paroxetine hydrochloride hydrate (JP16);
Paroxetine hydrochloride tablets (JP16);
Paxil (TN)
Product
  Generic
PAROXETINE (Aidarex Pharmaceuticals LLC), PAROXETINE (Aurolife Pharma LLC), PAROXETINE (Clinical Solutions Wholesale), PAROXETINE (Lake Erie Medical DBA Quality Care Products LLC), PAROXETINE (NCS HealthCare of KY), PAROXETINE (Preferred Pharmaceuticals), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (STAT Rx USA LLC), PAROXETINE (Zydus Pharmaceuticals (USA)), PAROXETINE (American Health Packaging), PAROXETINE (Aurobindo Pharma Limited), PAROXETINE (Bryant Ranch Prepack), PAROXETINE (Bryant Ranch Prepack), PAROXETINE (Cardinal Health), PAROXETINE (Cardinal Health), PAROXETINE (Golden State Medical Supply), PAROXETINE (Greenstone LLC), PAROXETINE (H.J. Harkins Company), PAROXETINE (International Labs), PAROXETINE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), PAROXETINE (Lake Erie Medical DBA Quality Care Products LLC), PAROXETINE (McKesson Contract Packaging), PAROXETINE HYDROCHLORIDE (Mylan Institutional), PAROXETINE HYDROCHLORIDE (Mylan Pharmaceuticals), PAROXETINE HYDROCHLORIDE (New Horizon Rx Group), PAROXETINE HYDROCHLORIDE (Physicians Total Care), PAROXETINE (Preferred Pharmaceuticals), PAROXETINE HYDROCHLORIDE (REMEDYREPACK), PAROXETINE HYDROCHLORIDE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE HYDROCHLORIDE (REMEDYREPACK), PAROXETINE HYDROCHLORIDE (REMEDYREPACK), PAROXETINE HYDROCHLORIDE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE (Rebel Distributors Corp), PAROXETINE (STAT Rx USA LLC), PAROXETINE (Aphena Pharma Solutions - Tennessee), PAROXETINE (Cardinal Health), PAROXETINE (Mylan Institutional), PAROXETINE (Mylan Pharmaceuticals), PAROXETINE (PD-Rx Pharmaceuticals), PAROXETINE (PD-Rx Pharmaceuticals), PAROXETINE (PD-Rx Pharmaceuticals), PAROXETINE (REMEDYREPACK), PAROXETINE (State of Florida DOH Central Pharmacy), PAROXETINE (State of Florida DOH Central Pharmacy)
Formula
(C19H20FNO3. HCl)2. H2O
Exact mass
748.2494
Mol weight
749.668
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidepressant
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Selective serotonin reuptake inhibitor (SSRI)
Target
serotonin transporter inhibitor [HSA:6532] [KO:K05037]
  Pathway
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Transporter: ABCB1 [HSA:5243]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AB Selective serotonin reuptake inhibitors
     N06AB05 Paroxetine
      D02260  Paroxetine hydrochloride hydrate (JAN)
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Paroxetine
    D02260  Paroxetine hydrochloride hydrate (JAN)
 Anxiolytics
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Paroxetine
    D02260  Paroxetine hydrochloride hydrate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D02260  Paroxetine hydrochloride hydrate (JP16); Paroxetine hydrochloride tablets (JP16)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (serotonin transporter)
     Paroxetine
      D02260  Paroxetine hydrochloride hydrate (JAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Paroxetine
    D02260  Paroxetine hydrochloride hydrate (JAN)
 Inhbitors
  CYP2D6
   Paroxetine
    D02260  Paroxetine hydrochloride hydrate (JAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02260  Paroxetine hydrochloride hydrate
  D02260  Paroxetine hydrochloride tablets
BRITE hierarchy
Other DBs
PubChem: 
DrugBank: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        51
            1   O0  O    41.1566  -17.6442
            2   C1y C    33.8100  -18.5500
            3   C1y C    32.5500  -19.2500
            4   C8y C    33.8100  -17.1500
            5   C1x C    35.0000  -19.2500
            6   C1b C    31.3600  -18.5500
            7   C1x C    32.5500  -20.6500
            8   C8x C    35.0000  -16.4500
            9   C8x C    32.5500  -16.4500
            10  C1x C    35.0000  -20.6500
            11  O2a O    30.1700  -19.2500
            12  N1x N    33.8100  -21.3500
            13  C8x C    35.0000  -15.0500
            14  C8x C    32.5500  -15.0500
            15  C8y C    28.9100  -18.5500
            16  C8y C    33.8100  -14.3500
            17  C8x C    28.9100  -17.1500
            18  C8x C    27.7200  -19.2500
            19  X   F    33.8100  -12.9500
            20  C8y C    27.7200  -16.4500
            21  C8x C    26.5300  -18.5500
            22  C8y C    26.5300  -17.1500
            23  O2x O    27.4400  -15.1200
            24  O2x O    25.4800  -16.2400
            25  C1x C    26.0400  -14.9100
            26  X   Cl   37.7300  -17.5700
            27  C1y C    33.8100  -18.5500
            28  C1y C    32.5500  -19.2500
            29  C1b C    31.3600  -18.5500
            30  O2a O    30.1700  -19.2500
            31  C8y C    28.9100  -18.5500
            32  C8x C    28.9100  -17.1500
            33  C8y C    27.7200  -16.4500
            34  C8y C    26.5300  -17.1500
            35  C8x C    26.5300  -18.5500
            36  C8x C    27.7200  -19.2500
            37  O2x O    25.4800  -16.2400
            38  C1x C    26.0400  -14.9100
            39  O2x O    27.4400  -15.1200
            40  C1x C    32.5500  -20.6500
            41  N1x N    33.8100  -21.3500
            42  C1x C    35.0000  -20.6500
            43  C1x C    35.0000  -19.2500
            44  C8y C    33.8100  -17.1500
            45  C8x C    35.0000  -16.4500
            46  C8x C    35.0000  -15.0500
            47  C8y C    33.8100  -14.3500
            48  C8x C    32.5500  -15.0500
            49  C8x C    32.5500  -16.4500
            50  X   F    33.8100  -12.9500
            51  X   Cl   37.7300  -17.5700
BOND        54
            1    14  16 1
            2    21  22 1
            3    24  25 1
            4     2   3 1
            5     2   4 1 #Down
            6     2   5 1
            7     3   6 1 #Up
            8     3   7 1
            9     4   8 2
            10    4   9 1
            11    5  10 1
            12    6  11 1
            13    7  12 1
            14    8  13 1
            15    9  14 2
            16   11  15 1
            17   13  16 2
            18   15  17 2
            19   15  18 1
            20   16  19 1
            21   17  20 1
            22   18  21 2
            23   20  22 2
            24   20  23 1
            25   22  24 1
            26   23  25 1
            27   10  12 1
            28   48  47 1
            29   35  34 1
            30   37  38 1
            31   27  28 1
            32   27  44 1 #Down
            33   27  43 1
            34   28  29 1 #Up
            35   28  40 1
            36   44  45 2
            37   44  49 1
            38   43  42 1
            39   29  30 1
            40   40  41 1
            41   45  46 1
            42   49  48 2
            43   30  31 1
            44   46  47 2
            45   31  32 2
            46   31  36 1
            47   47  50 1
            48   32  33 1
            49   36  35 2
            50   33  34 2
            51   33  39 1
            52   34  37 1
            53   39  38 1
            54   42  41 1
BRACKET     1    25.0600  -22.8200   25.0600  -12.2500
            1    38.5000  -12.2500   38.5000  -22.8200
            1  2
 ORIGINAL  1    2   3   6  11  15  17  20  22  21  18  24  25  23   7  12  10
            1    5   4   8  13  16  14   9  19  26
 REPEAT    1   27  28  29  30  31  32  33  34  35  36  37  38  39  40  41  42
            1   43  44  45  46  47  48  49  50  51

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