KEGG   DRUG: D02272Help
Entry
D02272                      Drug                                   

Name
Quinidine sulfate hydrate (JP16);
Quinidine sulfate (USP);
Quinidex (TN)
Product
  Generic
Formula
(C20H24N2O2)2. H2SO4. 2H2O
Exact mass
782.3561
Mol weight
782.9426
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Cardiac depressant [anti-arrhythmic]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Class I antiarrhythmic agent (Ia)
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Transporter: SLC22A1 [HSA:6580], SLC22A3 [HSA:6581]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP2D6 [HSA:1565]
Transporter inhibition: SLC22A2 [HSA:6582], SLC22A1 [HSA:6580], SLC47A1 [HSA:55244], SCL47A2 [HSA:146802], ABCB1 [HSA:5243]
Drug interaction
Structure map
Quinolines
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BA Antiarrhythmics, class Ia
     C01BA01 Quinidine
      D02272  Quinidine sulfate hydrate (JP16); Quinidine sulfate (USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Quinidine
    D02272  Quinidine sulfate hydrate (JP16); Quinidine sulfate (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2122  Quinidines
     D02272  Quinidine sulfate hydrate (JP16); Quinidine sulfate (USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Quinidine
      D02272  Quinidine sulfate (USP)
    voltage-gated sodium channel (SCN2A)
     Quinidine
      D02272  Quinidine sulfate (USP)
    voltage-gated sodium channel (SCN3A)
     Quinidine
      D02272  Quinidine sulfate (USP)
    voltage-gated sodium channel (SCN4A)
     Quinidine
      D02272  Quinidine sulfate (USP)
    voltage-gated sodium channel (SCN5A)
     Quinidine
      D02272  Quinidine sulfate (USP)
    voltage-gated sodium channel (SCN8A)
     Quinidine
      D02272  Quinidine sulfate (USP)
    voltage-gated sodium channel (SCN9A)
     Quinidine
      D02272  Quinidine sulfate (USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Quinidine
    D02272  Quinidine sulfate hydrate (JP16); Quinidine sulfate (USP)
 Inhbitors
  CYP2D6
   Quinidine
    D02272  Quinidine sulfate hydrate (JP16); Quinidine sulfate (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02272  Quinidine sulfate hydrate
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from tryptophan and anthranillic acid
   Quinoline alkaloids
    D02272  Quinidine sulfate (JP15/USP)
BRITE hierarchy
Other DBs
CAS: 
6591-63-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        55
            1   C8y C    19.1695  -25.8213
            2   C8y C    20.3898  -25.1264
            3   C8y C    19.1636  -27.2226
            4   C8x C    17.9666  -25.1206
            5   C1c C    20.3956  -23.7251
            6   C8x C    21.6100  -25.8330
            7   C8x C    17.9666  -27.9291
            8   N5x N    20.3782  -27.9348
            9   C8y C    16.7463  -25.8213
            10  C1y C    21.6217  -23.0186
            11  O1a O    19.1812  -23.0070
            12  C8x C    21.6042  -27.2342
            13  C8x C    16.7463  -27.2226
            14  O2a O    15.5319  -25.1206
            15  N1y N    23.0581  -22.1429
            16  C1x C    20.8919  -21.9734
            17  C1a C    15.5319  -23.7193
            18  C1x C    23.0581  -20.9050
            19  C1x C    24.5586  -22.9485
            20  C1y C    22.3049  -21.1385
            21  C1y C    22.3107  -20.1518
            22  C1x C    23.8639  -21.8391
            23  C2b C    21.7736  -18.8497
            24  C2a C    22.6376  -17.7405
            25  S4a S    28.9727  -21.0527
            26  O1d O    30.3683  -21.0584
            27  O1d O    27.5773  -21.0527
            28  O1d O    28.9670  -22.4481
            29  O1d O    28.9670  -19.6514
            30  O0  O    29.7500  -25.6200
            31  C8y C    19.1695  -25.8213
            32  C8y C    20.3898  -25.1264
            33  C1c C    20.3956  -23.7251
            34  C1y C    21.6217  -23.0186
            35  N1y N    23.0581  -22.1429
            36  C1x C    23.0581  -20.9050
            37  C1y C    22.3107  -20.1518
            38  C2b C    21.7736  -18.8497
            39  C2a C    22.6376  -17.7405
            40  C1y C    22.3049  -21.1385
            41  C1x C    20.8919  -21.9734
            42  C1x C    23.8639  -21.8391
            43  C1x C    24.5586  -22.9485
            44  O1a O    19.1812  -23.0070
            45  C8x C    21.6100  -25.8330
            46  C8x C    21.6042  -27.2342
            47  N5x N    20.3782  -27.9348
            48  C8y C    19.1636  -27.2226
            49  C8x C    17.9666  -27.9291
            50  C8x C    16.7463  -27.2226
            51  C8y C    16.7463  -25.8213
            52  C8x C    17.9666  -25.1206
            53  O2a O    15.5319  -25.1206
            54  C1a C    15.5319  -23.7193
            55  O0  O    29.7500  -25.6200
BOND        58
            1    25  26 1
            2    25  27 1
            3    25  28 2
            4    25  29 2
            5     1   2 1
            6     1   3 1
            7     1   4 2
            8     2   5 1
            9     2   6 2
            10    3   7 2
            11    3   8 1
            12    4   9 1
            13    5  10 1
            14    5  11 1 #Down
            15    6  12 1
            16    7  13 1
            17    9  14 1
            18   10  15 1
            19   10  16 1
            20   14  17 1
            21   15  18 1
            22   15  19 1
            23   16  20 1
            24   18  21 1
            25   19  22 1
            26   21  23 1 #Up
            27   23  24 2
            28    8  12 2
            29    9  13 2
            30   20  21 1
            31   20  22 1
            32   31  32 1
            33   31  48 1
            34   31  52 2
            35   32  33 1
            36   32  45 2
            37   48  49 2
            38   48  47 1
            39   52  51 1
            40   33  34 1
            41   33  44 1 #Down
            42   45  46 1
            43   49  50 1
            44   51  53 1
            45   34  35 1
            46   34  41 1
            47   53  54 1
            48   35  36 1
            49   35  43 1
            50   41  40 1
            51   36  37 1
            52   43  42 1
            53   37  38 1 #Up
            54   38  39 2
            55   47  46 2
            56   51  50 2
            57   40  37 1
            58   40  42 1
BRACKET     1    14.7000  -28.9100   14.7000  -16.8700
            1    25.2700  -16.8700   25.2700  -28.9100
            1  2
 ORIGINAL  1    1   2   5  10  15  18  21  23  24  20  16  22  19  25  11   6
            1   12   8   3   7  13   9   4  14  17
 REPEAT    1   32  33  34  35  36  37  38  39  40  41  42  43  44  45  46  47
            1   48  49  50  51  52  53  54  55  56
            2    27.5800  -26.5300   27.5800  -24.7800
            2    30.3800  -24.7800   30.3800  -26.5300
            2  2
 ORIGINAL  2   31
 REPEAT    2   57

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