KEGG   DRUG: Quinidine sulfateHelp
Entry
D02272                      Drug                                   

Name
Quinidine sulfate (USP);
Quinidine sulfate hydrate (JP17);
Quinidex (TN)
Product
  Generic
Formula
(C20H24N2O2)2. H2SO4. 2H2O
Exact mass
782.3561
Mol weight
782.9426
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01649  Class Ia antiarrhythmic agent
Cyp substrate
 DG01633  CYP3A4 substrate
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antiarrhythmic, Sodium channel blocker
Comment
Class I antiarrhythmic agent (Ia)
Target
SCN1A [HSA:6323] [KO:K04833];
SCN2A [HSA:6326] [KO:K04834];
SCN3A [HSA:6328] [KO:K04836];
SCN4A [HSA:6329] [KO:K04837];
SCN5A [HSA:6331] [KO:K04838];
SCN8A [HSA:6334] [KO:K04840];
SCN9A [HSA:6335] [KO:K04841]
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Transporter: SLC22A1 [HSA:6580], SLC22A3 [HSA:6581]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP2D6 [HSA:1565]
Transporter inhibition: SLC22A2 [HSA:6582], SLC22A1 [HSA:6580], SLC47A1 [HSA:55244], SCL47A2 [HSA:146802], ABCB1 [HSA:5243]
Drug interaction
Structure map
Quinolines
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BA Antiarrhythmics, class Ia
     C01BA01 Quinidine
      D02272  Quinidine sulfate (USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Quinidine
    D02272  Quinidine sulfate (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2122  Quinidines
     D02272  Quinidine sulfate (USP); Quinidine sulfate hydrate (JP17)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Quinidine
      D02272  Quinidine sulfate (USP)
    voltage-gated sodium channel (SCN2A)
     Quinidine
      D02272  Quinidine sulfate (USP)
    voltage-gated sodium channel (SCN3A)
     Quinidine
      D02272  Quinidine sulfate (USP)
    voltage-gated sodium channel (SCN4A)
     Quinidine
      D02272  Quinidine sulfate (USP)
    voltage-gated sodium channel (SCN5A)
     Quinidine
      D02272  Quinidine sulfate (USP)
    voltage-gated sodium channel (SCN8A)
     Quinidine
      D02272  Quinidine sulfate (USP)
    voltage-gated sodium channel (SCN9A)
     Quinidine
      D02272  Quinidine sulfate (USP)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2D6
   Quinidine
    D02272  Quinidine sulfate (USP)
 CYP substrates
  CYP3A4
   Quinidine
    D02272  Quinidine sulfate (USP)
  CYP3A
   Quinidine
    D02272  Quinidine sulfate (USP)
 Transporter inhibitors
  ABCB1
   Quinidine
    D02272  Quinidine sulfate (USP)
  SLC22A1
   Quinidine
    D02272  Quinidine sulfate (USP)
  SLC22A2
   Quinidine
    D02272  Quinidine sulfate (USP)
  MATE1
   Quinidine
    D02272  Quinidine sulfate (USP)
  MATE2
   Quinidine
    D02272  Quinidine sulfate (USP)
 Transporter substrates
  ABCB1
   Quinidine
    D02272  Quinidine sulfate (USP)
  SLC22A1
   Quinidine
    D02272  Quinidine sulfate (USP)
  SLC22A3
   Quinidine
    D02272  Quinidine sulfate (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02272  Quinidine sulfate hydrate
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from tryptophan and anthranillic acid
   Quinoline alkaloids
    D02272  Quinidine sulfate (JP15/USP)
Cardiovascular agents [br08364.html]
 Antiarrhythmics
  D02272
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D02272
BRITE hierarchy
Other DBs
CAS: 
6591-63-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        55
            1   C8y C    19.1695  -25.8213
            2   C8y C    20.3898  -25.1264
            3   C8y C    19.1636  -27.2226
            4   C8x C    17.9666  -25.1206
            5   C1c C    20.3956  -23.7251
            6   C8x C    21.6100  -25.8330
            7   C8x C    17.9666  -27.9291
            8   N5x N    20.3782  -27.9348
            9   C8y C    16.7463  -25.8213
            10  C1y C    21.6217  -23.0186
            11  O1a O    19.1812  -23.0070
            12  C8x C    21.6042  -27.2342
            13  C8x C    16.7463  -27.2226
            14  O2a O    15.5319  -25.1206
            15  N1y N    23.0581  -22.1429
            16  C1x C    20.8919  -21.9734
            17  C1a C    15.5319  -23.7193
            18  C1x C    23.0581  -20.9050
            19  C1x C    24.5586  -22.9485
            20  C1y C    22.3049  -21.1385
            21  C1y C    22.3107  -20.1518
            22  C1x C    23.8639  -21.8391
            23  C2b C    21.7736  -18.8497
            24  C2a C    22.6376  -17.7405
            25  S4a S    28.9727  -21.0527
            26  O1d O    30.3683  -21.0584
            27  O1d O    27.5773  -21.0527
            28  O1d O    28.9670  -22.4481
            29  O1d O    28.9670  -19.6514
            30  O0  O    29.7500  -25.6200
            31  C8y C    19.1695  -25.8213
            32  C8y C    20.3898  -25.1264
            33  C1c C    20.3956  -23.7251
            34  C1y C    21.6217  -23.0186
            35  N1y N    23.0581  -22.1429
            36  C1x C    23.0581  -20.9050
            37  C1y C    22.3107  -20.1518
            38  C2b C    21.7736  -18.8497
            39  C2a C    22.6376  -17.7405
            40  C1y C    22.3049  -21.1385
            41  C1x C    20.8919  -21.9734
            42  C1x C    23.8639  -21.8391
            43  C1x C    24.5586  -22.9485
            44  O1a O    19.1812  -23.0070
            45  C8x C    21.6100  -25.8330
            46  C8x C    21.6042  -27.2342
            47  N5x N    20.3782  -27.9348
            48  C8y C    19.1636  -27.2226
            49  C8x C    17.9666  -27.9291
            50  C8x C    16.7463  -27.2226
            51  C8y C    16.7463  -25.8213
            52  C8x C    17.9666  -25.1206
            53  O2a O    15.5319  -25.1206
            54  C1a C    15.5319  -23.7193
            55  O0  O    29.7500  -25.6200
BOND        58
            1    25  26 1
            2    25  27 1
            3    25  28 2
            4    25  29 2
            5     1   2 1
            6     1   3 1
            7     1   4 2
            8     2   5 1
            9     2   6 2
            10    3   7 2
            11    3   8 1
            12    4   9 1
            13    5  10 1
            14    5  11 1 #Down
            15    6  12 1
            16    7  13 1
            17    9  14 1
            18   10  15 1
            19   10  16 1
            20   14  17 1
            21   15  18 1
            22   15  19 1
            23   16  20 1
            24   18  21 1
            25   19  22 1
            26   21  23 1 #Up
            27   23  24 2
            28    8  12 2
            29    9  13 2
            30   20  21 1
            31   20  22 1
            32   31  32 1
            33   31  48 1
            34   31  52 2
            35   32  33 1
            36   32  45 2
            37   48  49 2
            38   48  47 1
            39   52  51 1
            40   33  34 1
            41   33  44 1 #Down
            42   45  46 1
            43   49  50 1
            44   51  53 1
            45   34  35 1
            46   34  41 1
            47   53  54 1
            48   35  36 1
            49   35  43 1
            50   41  40 1
            51   36  37 1
            52   43  42 1
            53   37  38 1 #Up
            54   38  39 2
            55   47  46 2
            56   51  50 2
            57   40  37 1
            58   40  42 1
BRACKET     1    14.7000  -28.9100   14.7000  -16.8700
            1    25.2700  -16.8700   25.2700  -28.9100
            1  2
 ORIGINAL  1    1   2   5  10  15  18  21  23  24  20  16  22  19  25  11   6
            1   12   8   3   7  13   9   4  14  17
 REPEAT    1   32  33  34  35  36  37  38  39  40  41  42  43  44  45  46  47
            1   48  49  50  51  52  53  54  55  56
            2    27.5800  -26.5300   27.5800  -24.7800
            2    30.3800  -24.7800   30.3800  -26.5300
            2  2
 ORIGINAL  2   31
 REPEAT    2   57

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