KEGG   DRUG: D02408Help
Entry
D02408                      Drug                                   

Name
Trimipramine maleate (JAN/USAN);
Surmontil (TN)
Product
  Generic
Formula
C20H26N2. C4H4O4
Exact mass
410.2206
Mol weight
410.506
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidepressant
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Tricyclic antidepressants
Target
noradrenalin transporter inhibitor [HSA:6530] [KO:K05035];
serotonin transporter inhibitor [HSA:6532] [KO:K05037]
  Pathway
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AA Non-selective monoamine reuptake inhibitors
     N06AA06 Trimipramine
      D02408  Trimipramine maleate (JAN/USAN)
USP drug classification [BR:br08302]
 Antidepressants
  Tricyclics
   Trimipramine
    D02408  Trimipramine maleate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1174  Imipramines
     D02408  Trimipramine maleate (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter)
     Trimipramine
      D02408  Trimipramine maleate (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Trimipramine
    D02408  Trimipramine maleate (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
521-78-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        30
            1   C6a C    38.9900  -19.7400
            2   C2b C    38.2900  -18.6200
            3   O6a O    38.2900  -20.9300
            4   O6a O    40.3200  -19.7400
            5   C2b C    36.6100  -18.6200
            6   C6a C    35.9100  -19.7400
            7   O6a O    34.5100  -19.7400
            8   O6a O    36.6100  -20.9300
            9   C1x C    26.5300  -22.2600
            10  C8y C    25.6900  -21.1400
            11  C8y C    26.0400  -19.8100
            12  N1y N    27.3000  -19.2500
            13  C1x C    27.9300  -22.2600
            14  C8y C    28.5600  -19.8800
            15  C8y C    28.8400  -21.2100
            16  C8x C    24.9900  -18.8300
            17  C8x C    23.6600  -19.2500
            18  C8x C    23.3100  -20.5800
            19  C8x C    24.3600  -21.5600
            20  C8x C    30.1700  -21.6300
            21  C8x C    31.2200  -20.7200
            22  C8x C    30.9400  -19.3200
            23  C8x C    29.6100  -18.9000
            24  C1b C    27.3000  -17.8500
            25  C1c C    28.5124  -17.1500
            26  C1b C    29.7079  -17.8404
            27  C1a C    28.5125  -15.7502
            28  N1c N    30.8953  -17.1549
            29  C1a C    32.0865  -17.8429
            30  C1a C    30.8955  -15.7502
BOND        31
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     5   6 1
            6     6   7 1
            7     6   8 2
            8    11  12 1
            9     9  13 1
            10   12  14 1
            11   10  11 1
            12   13  15 1
            13    9  10 1
            14   14  15 1
            15   11  16 2
            16   16  17 1
            17   17  18 2
            18   18  19 1
            19   10  19 2
            20   15  20 2
            21   20  21 1
            22   21  22 2
            23   22  23 1
            24   14  23 2
            25   12  24 1
            26   24  25 1
            27   25  26 1
            28   25  27 1
            29   26  28 1
            30   28  29 1
            31   28  30 1

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