KEGG   DRUG: Atomoxetine hydrochlorideHelp
Entry
D02574                      Drug                                   

Name
Atomoxetine hydrochloride (JAN/USAN);
Tomoxetine hydrochloride;
Strattera (TN)
Product
  Generic
Formula
C17H21NO. HCl
Exact mass
291.139
Mol weight
291.8157
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cyp substrate
 DG01644  CYP2D6 substrate
Unclassified
 DG01970  Agents for ADHD
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Stimulant (central), sNRI
Comment
selective norepinephrine reuptake inhibitor (sNRI)
Treatment of attention deficit hyperactivity disorder (ADHD)
Target
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA09 Atomoxetine
      D02574  Atomoxetine hydrochloride (JAN/USAN)
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Attention Deficit Hyperactivity Disorder Agents, Non- amphetamines
   Atomoxetine
    D02574  Atomoxetine hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D02574  Atomoxetine hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter)
     Atomoxetine
      D02574  Atomoxetine hydrochloride (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2D6
   Atomoxetine
    D02574  Atomoxetine hydrochloride (JAN/USAN)
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D02574
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D02574
BRITE hierarchy
Other DBs
CAS: 
82248-59-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        20
            1   C8x C    11.5500  -14.3500
            2   C8x C    11.5500  -15.7500
            3   C8x C    12.7624  -16.4500
            4   C8x C    13.9749  -15.7500
            5   C8y C    13.9749  -14.3500
            6   C8y C    12.7624  -13.6500
            7   C1a C    12.7624  -12.2502
            8   O2a O    15.2124  -13.6500
            9   C1c C    16.4249  -14.3500
            10  C1b C    17.6373  -13.6500
            11  C1b C    18.8497  -14.3500
            12  N1b N    20.0622  -13.6500
            13  C1a C    21.2746  -14.3500
            14  C8y C    16.4249  -15.7498
            15  C8x C    15.2313  -16.4391
            16  C8x C    15.2315  -17.8391
            17  C8x C    16.4441  -18.5389
            18  C8x C    17.6376  -17.8496
            19  C8x C    17.6374  -16.4496
            20  X   Cl   26.6700  -14.4200
BOND        20
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     5   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    9  14 1 #Down
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   14  19 1

» Japanese version   » Back

DBGET integrated database retrieval system