KEGG   DRUG: D02666Help
Entry
D02666                      Drug                                   

Name
Iloperidone (USAN/INN);
Fanapt (TN)
Product
Formula
C24H27FN2O4
Exact mass
426.1955
Mol weight
426.4806
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antipsychotic
Remark
ATC code: 
Drug group: 
Target
5-HT2A-receptor antagonist [HSA:3356] [KO:K04157];
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction  
 
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AX Other antipsychotics
     N05AX14 Iloperidone
      D02666  Iloperidone (USAN/INN)
USP drug classification [BR:br08302]
 Antipsychotics
  2nd Generation/Atypical
   Iloperidone
    D02666  Iloperidone (USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor
     Iloperidone
      D02666  Iloperidone (USAN/INN)
   Serotonin
    5-HT2A-receptor
     Iloperidone
      D02666  Iloperidone (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
133454-47-4
PubChem: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        31
            1   O2x O    20.8600  -29.1900
            2   C8y C    21.2800  -30.5200
            3   C8y C    22.6800  -30.5200
            4   C8y C    23.1000  -29.1900
            5   N5x N    21.9800  -28.3500
            6   C1x C    24.2900  -27.0900
            7   C1y C    24.2900  -28.4900
            8   C1x C    25.4800  -29.1900
            9   C1x C    26.7400  -28.4900
            10  N1y N    26.7400  -27.0900
            11  C1x C    25.4800  -26.3900
            12  C8x C    20.5800  -31.7324
            13  C8y C    21.2800  -32.9449
            14  C8x C    22.6800  -32.9449
            15  C8x C    23.3800  -31.7324
            16  X   F    20.5690  -34.1760
            17  C1b C    27.9466  -26.3800
            18  C1b C    29.1563  -27.0653
            19  C1b C    30.3766  -26.3470
            20  O2a O    31.5858  -27.0313
            21  C8y C    32.7852  -26.3249
            22  C8y C    33.9824  -27.0024
            23  C8x C    35.1888  -26.2920
            24  C8y C    35.1768  -24.8921
            25  C8x C    33.9796  -24.2146
            26  C8x C    32.7732  -24.9249
            27  C5a C    36.3949  -24.1743
            28  C1a C    37.6068  -24.8596
            29  O5a O    36.3821  -22.7501
            30  O2a O    33.9250  -28.4193
            31  C1a C    32.7046  -29.0596
BOND        34
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 2
            5     1   5 1
            6     6   7 1
            7     7   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11    6  11 1
            12    7   4 1
            13    2  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    3  15 2
            18   13  16 1
            19   10  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 2
            25   22  23 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   21  26 1
            30   24  27 1
            31   27  28 1
            32   27  29 2
            33   22  30 1
            34   30  31 1

» Japanese version   » Back

DBGET integrated database retrieval system