KEGG   DRUG: D02748Help
Entry
D02748                      Drug                                   

Name
Peginterferon alfa-2b (generical recombination) (JAN);
Peginterferon alfa-2b (INN);
Pegintron (TN);
Sylatron (TN)
Product
Formula
C2H3O2R(C2H4O)n
Structure
Mol fileKCF fileDB searchJmolKegDraw
Sequence
CDLPQTHSLG SRRTLMLLAQ MRRISLFSCL KDRHDFGFPQ EEFGNQFQKA ETIPVLHEMI
QQIFNLFSTK DSSAAWDETL LDKFYTELYQ QLNDLEACVI QGVGVTETPL MKEDSILAVR
KYFQRITLYL KEKKYSPCAW EVVRAEIMRS FSLSTNLQES LRSKE
(Disulfide bridge: 1-98; 29-138, Pegylation site: 1; 31; 121; 134)
  Type
Peptide
Activity
[DS:H00413]
Remark
Therapeutic category: 
ATC code: 
Comment
R: Interferon alfa-2b [DR:D02745]
Target
interferon receptor 1 agonist [HSA:3454] [KO:K05130];
interferon receptor 2 agonist [HSA:3455] [KO:K05131]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04620  Toll-like receptor signaling pathway
hsa04630  Jak-STAT signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity  
 
Interaction
Genomic biomarker: IL28B [HSA:282617]
Drug interaction
Structure map
Antiviral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L03 IMMUNOSTIMULANTS
   L03A IMMUNOSTIMULANTS
    L03AB Interferons
     L03AB10 Peginterferon alfa-2b
      D02748  Peginterferon alfa-2b (generical recombination) (JAN); Peginterferon alfa-2b (INN)
USP drug classification [BR:br08302]
 Antivirals
  Anti-hepatitis B (HBV) Agents
   Peginterferon Alfa-2b
    D02748  Peginterferon alfa-2b (generical recombination) (JAN); Peginterferon alfa-2b (INN)
  Anti-hepatitis C (HCV) Agents
   Peginterferon Alfa-2b
    D02748  Peginterferon alfa-2b (generical recombination) (JAN); Peginterferon alfa-2b (INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  63  Biological preparations
   639  Miscellaneous
    6399  Others
     D02748  Peginterferon alfa-2b (generical recombination) (JAN); Peginterferon alfa-2b (INN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Class II cytokine receptors (interferon/IL-10 family receptors)
   interferon receptor 1
    Peginterferon alfa-2b
     D02748  Peginterferon alfa-2b (generical recombination) (JAN); Peginterferon alfa-2b (INN)
   interferon receptor 2
    Peginterferon alfa-2b
     D02748  Peginterferon alfa-2b (generical recombination) (JAN); Peginterferon alfa-2b (INN)
BRITE hierarchy
Other DBs
CAS: 
215647-85-1
PubChem: 
DrugBank: 
LinkDB All DBs
KCF data Show

ATOM        8
            1   C7a C    23.8000  -25.4800
            2   R   R    25.0124  -26.1800
            3   O7a O    22.5876  -26.1800
            4   O6a O    23.8000  -24.0800
            5   C1b C    21.3921  -25.4896
            6   C1b C    20.2047  -26.1751
            7   O2a O    19.0135  -25.4871
            8   C1a C    17.8240  -26.1738
BOND        7
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     3   5 1
            5     5   6 1
            6     6   7 1
            7     7   8 1
BRACKET     1    18.6900  -27.1600   18.6900  -25.0600
            1    21.5600  -25.0600   21.5600  -27.1600
            1  n
 ORIGINAL  1    5   6   7
 REPEAT    1

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