KEGG   DRUG: AxitinibHelp
Entry
D03218                      Drug                                   

Name
Axitinib (JAN/USAN);
Inlyta (TN)
Product
Formula
C22H18N4OS
Exact mass
386.1201
Mol weight
386.4695
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Cyp substrate
 DG01892  CYP1A2 substrate
 DG01633  CYP3A4 substrate
Remark
Therapeutic category: 
ATC code: 
Activity
Antineoplastic, Inhibitor of VEGF/PDGF tyrosine kinases
  Disease
Renal cell carcinoma [DS:H00021]
Target
PDGFRB [HSA:5159] [KO:K05089];
VEGFR1 (FLT1) [HSA:2321] [KO:K05096];
VEGFR2 (KDR) [HSA:3791] [KO:K05098];
VEGFR3 (FLT4) [HSA:2324] [KO:K05097];
KIT (CD117) [HSA:3815] [KO:K05091]
  Pathway
MAPK signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
VEGF signaling pathway
Pathways in cancer
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP1A2 [HSA:1544], CYP2C19 [HSA:1557], UGT1A1 [HSA:54658]
Interaction
Drug interaction
Structure map
Antineoplastics - protein kinases inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XE Protein kinase inhibitors
     L01XE17 Axitinib
      D03218  Axitinib (JAN/USAN)
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Axitinib
    D03218  Axitinib (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D03218  Axitinib (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    PDGFRB tyrosine kinase
     Axitinib
      D03218  Axitinib (JAN/USAN)
    c-KIT tyrosine kinase
     Axitinib
      D03218  Axitinib (JAN/USAN)
   RTK class V (VEGF receptor family)
    VEGFR1 tyrosine kinase
     Axitinib
      D03218  Axitinib (JAN/USAN)
    VEGFR2 tyrosine kinase
     Axitinib
      D03218  Axitinib (JAN/USAN)
    VEGFR3 tyrosine kinase
     Axitinib
      D03218  Axitinib (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP3A4
   Axitinib
    D03218  Axitinib (JAN/USAN)
  CYP3A5
   Axitinib
    D03218  Axitinib (JAN/USAN)
Antineoplastics [br08340.html]
 D03218
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D03218
BRITE hierarchy
Other DBs
CAS: 
319460-85-0
PubChem: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        28
            1   C8y C    13.1600  -21.9100
            2   C8x C    13.1600  -23.3100
            3   C8x C    14.4200  -24.0100
            4   C8y C    15.6100  -23.3100
            5   C8y C    15.6100  -21.9100
            6   C8x C    14.4200  -21.2100
            7   C8y C    16.9400  -23.7300
            8   N5x N    17.7800  -22.6100
            9   N4x N    16.9400  -21.4900
            10  S2a S    11.9700  -21.2100
            11  C8y C    10.7800  -21.9100
            12  C8y C     9.5900  -21.2100
            13  C8x C     8.3300  -21.9100
            14  C8x C     8.3300  -23.3100
            15  C8x C     9.5200  -24.0100
            16  C8x C    10.7800  -23.3100
            17  C5a C     9.5900  -19.8100
            18  N1b N     8.3300  -19.1100
            19  O5a O    10.7800  -19.1100
            20  C1a C     7.1400  -19.8100
            21  C2b C    16.9400  -25.2000
            22  C2b C    18.2000  -25.9000
            23  C8y C    18.2172  -27.2999
            24  N5x N    17.0008  -28.0224
            25  C8x C    17.0181  -29.4223
            26  C8x C    18.2391  -30.1073
            27  C8x C    19.4556  -29.3847
            28  C8x C    19.4382  -27.9848
BOND        31
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    5   9 1
            11    1  10 1
            12   10  11 1
            13   11  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   11  16 1
            19   12  17 1
            20   17  18 1
            21   17  19 2
            22   18  20 1
            23    7  21 1
            24   21  22 2
            25   22  23 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   26  27 1
            30   27  28 2
            31   23  28 1

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