KEGG   DRUG: D03218Help
Entry
D03218                      Drug                                   

Name
Axitinib (JAN/USAN);
Inlyta (TN)
Product
Formula
C22H18N4OS
Exact mass
386.1201
Mol weight
386.4695
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antineoplastic, inhibitor of VEGF/PDGF tyrosine kinases [DS:H00021]
Remark
ATC code: 
Target
PDGFRB tyrosine kinase inhibitor [HSA:5159] [KO:K05089];
VEGFR1 tyrosine kinase inhibitor [HSA:2321] [KO:K05096];
VEGFR2 tyrosine kinase inhibitor [HSA:3791] [KO:K05098];
VEGFR3 tyrosine kinase inhibitor [HSA:2324] [KO:K05097];
c-KIT tyrosine kinase inhibitor [HSA:3815] [KO:K05091]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04370  VEGF signaling pathway
hsa05200  Pathways in cancer  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577]
Interaction
Drug interaction
Structure map
Antineoplastics - protein kinases inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XE Protein kinase inhibitors
     L01XE17 Axitinib
      D03218  Axitinib (JAN/USAN)
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Axitinib
    D03218  Axitinib (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    PDGFRB tyrosine kinase
     Axitinib
      D03218  Axitinib (JAN/USAN)
    c-KIT tyrosine kinase
     Axitinib
      D03218  Axitinib (JAN/USAN)
   RTK class V (VEGF receptor family)
    VEGFR1 tyrosine kinase
     Axitinib
      D03218  Axitinib (JAN/USAN)
    VEGFR2 tyrosine kinase
     Axitinib
      D03218  Axitinib (JAN/USAN)
    VEGFR3 tyrosine kinase
     Axitinib
      D03218  Axitinib (JAN/USAN)
Antineoplastics [BR:br08308]
 Molecularly targeted agents
  Receptor tyrosine kinase inhibitor
   Axitinib
    D03218  Axitinib (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Axitinib
    D03218  Axitinib (JAN/USAN)
  CYP3A5
   Axitinib
    D03218  Axitinib (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
319460-85-0
PubChem: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        28
            1   C8y C    13.1600  -21.9100
            2   C8x C    13.1600  -23.3100
            3   C8x C    14.4200  -24.0100
            4   C8y C    15.6100  -23.3100
            5   C8y C    15.6100  -21.9100
            6   C8x C    14.4200  -21.2100
            7   C8y C    16.9400  -23.7300
            8   N5x N    17.7800  -22.6100
            9   N4x N    16.9400  -21.4900
            10  S2a S    11.9700  -21.2100
            11  C8y C    10.7800  -21.9100
            12  C8y C     9.5900  -21.2100
            13  C8x C     8.3300  -21.9100
            14  C8x C     8.3300  -23.3100
            15  C8x C     9.5200  -24.0100
            16  C8x C    10.7800  -23.3100
            17  C5a C     9.5900  -19.8100
            18  N1b N     8.3300  -19.1100
            19  O5a O    10.7800  -19.1100
            20  C1a C     7.1400  -19.8100
            21  C2b C    16.9400  -25.2000
            22  C2b C    18.2000  -25.9000
            23  C8y C    18.2172  -27.2999
            24  N5x N    17.0008  -28.0224
            25  C8x C    17.0181  -29.4223
            26  C8x C    18.2391  -30.1073
            27  C8x C    19.4556  -29.3847
            28  C8x C    19.4382  -27.9848
BOND        31
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    5   9 1
            11    1  10 1
            12   10  11 1
            13   11  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   11  16 1
            19   12  17 1
            20   17  18 1
            21   17  19 2
            22   18  20 1
            23    7  21 1
            24   21  22 2
            25   22  23 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   26  27 1
            30   27  28 2
            31   23  28 1

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