KEGG   DRUG: BelataceptHelp
Entry
D03222                      Drug                                   

Name
Belatacept (USAN/INN);
Nulojix (TN)
Product
Formula
C3508H5440N922O1096S32
Exact mass
79042.9351
Mol weight
79092.329
Sequence
MHVAQPAVVL ASSRGIASFV CEYASPGKYT EVRVTVLRQA DSQVTEVCAA TYMMGNELTF
LDDSICTGTS SGNQVNLTIQ GLRAMDTGLY ICKVELMYPP PYYEGIGNGT QIYVIDPEPC
PDSDQEPKSS DKTHTSPPSP APELLGGSSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED
PEVKFNWYVD GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA
PIEKTISKAK GQPREPQVYT LPPSRDELTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN
YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGK
(Disulfide bridge: 21-92; 48-66; 171-231; 277-335, Dimer: 120)
  Type
Peptide
Remark
ATC code: 
Efficacy
Antirheumatic, Immunosuppressant
Comment
Fusion protein (extracellular domain of CTLA4 fused to Fc of a human IgG1)
Prevention of allograft rejection in recipients of solid organ transplants, Prevention of graft-vs.-host disease following bone marrow transplantation, Treatment of autoimmune diseases and conditions such as rheumatoid arthritis
Target
CTLA4 (CD152) [HSA:1493] [KO:K06538];
CD80 [HSA:941] [KO:K05412];
CD86 [HSA:942] [KO:K05413]
  Pathway
Cell adhesion molecules (CAMs)
T cell receptor signaling pathway
Rheumatoid arthritis
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AA Selective immunosuppressants
     L04AA28 Belatacept
      D03222  Belatacept (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Others
  Cellular antigens
   CD152 (CTLA4)
    Belatacept
     D03222  Belatacept (USAN/INN)
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D03222
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03222
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03222
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D03222
BRITE hierarchy
Other DBs
CAS: 
706808-37-9
PubChem: 
LinkDB All DBs

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