KEGG   DRUG: D03257Help
Entry
D03257                      Drug                                   

Name
Trastuzumab (genetical recombination) (JAN);
Trastuzumab (INN);
Herceptin (TN)
Product
Sequence
(Heavy chain) EVQLVESGGG LVQPGGSLRL SCAASGFNIK DTYIHWVRQA
PGKGLEWVAR IYPTNGYTRY ADSVKGRFTI SADTSKNTAY LQMNSLRAED TAVYYCSRWG
GDGFYAMDYW GQGTLVTVSS ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS
WNSGALTSGV HTFPAVLQSS GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKKVEP
KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW
YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS
KAKGQPREPQ VYTLPPSREE MTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV
LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPG
(Disulfide bridge: 22-96; 147-203; 264-324; 370-428, Dimer: 229; 232)
(Light chain) DIQMTQSPSS LSASVGDRVT ITCRASQDVN TAVAWYQQKP
GKAPKLLIYS ASFLYSGVPS RFSGSRSGTD FTLTISSLQP EDFATYYCQQ HYTTPPTFGQ
GTKVEIKRTV AAPSVFIFPP SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ
ESVTEQDSKD STYSLSSTLT LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: 23-88; 134-194; H223-L214, Dimer)
  Type
Peptide
Activity
Antineoplastic [DS:H00031]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
breast cancer treatment
Monoclonal antibody
Target
ERBB2 tyrosine kinase (HER2) [HSA:2064] [KO:K05083]
  Pathway
hsa04012  ErbB signaling pathway
hsa04510  Focal adhesion
hsa04520  Adherens junction
hsa05200  Pathways in cancer  
 
Interaction
Genomic biomarker: HER2 [HSA:2064]
Drug interaction
Structure map
Antineoplastics - protein kinases inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XC Monoclonal antibodies
     L01XC03 Trastuzumab
      D03257  Trastuzumab (genetical recombination) (JAN); Trastuzumab (INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D03257  Trastuzumab (genetical recombination) (JAN); Trastuzumab (INN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class I (EGF receptor family)
    ERBB2 tyrosine kinase
     Trastuzumab
      D03257  Trastuzumab (genetical recombination) (JAN); Trastuzumab (INN)
Antineoplastics [BR:br08308]
 Molecularly targeted agents
  Monoclonal antibody
   Trastuzumab
    D03257  Trastuzumab (genetical recombination) (JAN); Trastuzumab (INN)
BRITE hierarchy
Other DBs
CAS: 
180288-69-1
PubChem: 
DrugBank: 
NIKKAJI: 
LinkDB All DBs

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