KEGG   DRUG: D03682Help
Entry
D03682                      Drug                                   

Name
Denileukin diftitox (USAN/INN);
Ontak (TN)
Product
Formula
C2560H4036N678O799S17
Exact mass
57605.128
Mol weight
57640.606
Activity
Biological response modifier;
Antineoplastic
Remark
ATC code: 
Comment
Indication: recurrent cutaneous T-cell lymphoma
Denileukin diftitox consists of diphtheria toxin fragments fused to interleukin-2.
immunotoxin
Target
interleukin 2 receptor [HSA:3559 3560 3561] [KO:K05068 K05069 K05070]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04144  Endocytosis
hsa04630  Jak-STAT signaling pathway  
 
Interaction
Genomic biomarker: CD25 [HSA:3669]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XX Other antineoplastic agents
     L01XX29 Denileukin diftitox
      D03682  Denileukin diftitox (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Class I cytokine receptors (hematopoietin family receptors)
   interleukin 2 receptor
    Denileukin diftitox
     D03682  Denileukin diftitox (USAN/INN)
Antineoplastics [BR:br08308]
 Molecularly targeted agents
  Interleukin 2 receptor toxin
   Denileukin diftitox
    D03682  Denileukin diftitox (USAN/INN)
 Biologic response modifiers
  Interleukins
   Denileukin diftitox
    D03682  Denileukin diftitox (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
173146-27-5
PubChem: 
DrugBank: 
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