KEGG   DRUG: Eltrombopag olamineHelp
Entry
D03978                      Drug                                   

Name
Eltrombopag olamine (JAN/USAN);
Promacta (TN)
Product
Formula
C25H22N4O4. (C2H7NO)2
Exact mass
564.2696
Mol weight
564.6327
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cyp substrate
 DG01892  CYP1A2 substrate
Transporter substrate
 DG01913  BCRP substrate
Remark
Therapeutic category: 
ATC code: 
Activity
Treatment of chemotherapy-induced thrombocytopenia and treatment of immune thrombocytopenic purpura
  Disease
Chronic immune thrombocytopenia [DS:H01240]
Target
MPL (TPOR, CD110) [HSA:4352] [KO:K05082]
  Pathway
Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2C8 [HSA:1558]
Transporter: ABCG2 [HSA:9429], UGT1A1 [HSA:54658], UGT1A3 [HSA:54659]
Interaction
Genomic biomarker: F5 [HSA:2153], SERPINC1 [HSA:462]
Transporter inhibition: ABCG2 [HSA:9429], SLCO1B1 [HSA:10599]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BX Other systemic hemostatics
     B02BX05 Eltrombopag
      D03978  Eltrombopag olamine (JAN/USAN)
USP drug classification [BR:br08302]
 Blood Products/Modifiers/Volume Expanders
  Blood Formation Modifiers
   Eltrombopag olamine
    D03978  Eltrombopag olamine (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D03978  Eltrombopag olamine (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Class I cytokine receptors (hematopoietin family receptors)
   thrombopoietin receptor
    Eltrombopag
     D03978  Eltrombopag olamine (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP1A2
   Eltrombopag
    D03978  Eltrombopag olamine (JAN/USAN)
  CYP2C8
   Eltrombopag
    D03978  Eltrombopag olamine (JAN/USAN)
 Transporter inhibitors
  ABCG2
   Eltrombopag
    D03978  Eltrombopag olamine (JAN/USAN)
  SLCO1B1
   Eltrombopag
    D03978  Eltrombopag olamine (JAN/USAN)
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D03978
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D03978
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D03978
BRITE hierarchy
Other DBs
CAS: 
496775-62-3
PubChem: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        41
            1   N1a N    35.8702  -19.1003
            2   C1b C    37.0869  -18.3978
            3   C1b C    38.3036  -19.1003
            4   O1a O    39.5203  -18.3978
            5   N2x N    27.1600  -16.3800
            6   C2y C    28.5600  -16.3800
            7   C2y C    28.9926  -15.0485
            8   C5x C    27.8600  -14.2256
            9   N1y N    26.7274  -15.0485
            10  O5x O    27.8600  -12.8100
            11  C8y C    25.5149  -14.3485
            12  C8x C    24.3025  -15.0485
            13  N1b N    31.4175  -15.0485
            14  N2b N    30.2051  -14.3485
            15  C1a C    29.3829  -17.5126
            16  C8x C    25.5149  -12.9485
            17  C8x C    24.3025  -12.2485
            18  C8y C    23.0901  -12.9485
            19  C8y C    23.0901  -14.3485
            20  C8y C    32.6299  -14.3485
            21  C1a C    21.8845  -15.0446
            22  C1a C    21.8857  -12.2532
            23  C8y C    33.8355  -15.0446
            24  C8y C    35.0480  -14.3446
            25  C8x C    35.0480  -12.9446
            26  C8x C    33.8424  -12.2485
            27  C8x C    32.6300  -12.9485
            28  O1a O    33.8356  -16.4498
            29  C8y C    36.2792  -15.0556
            30  C8x C    36.2790  -16.4499
            31  C8x C    37.4913  -17.1501
            32  C8x C    38.7038  -16.4502
            33  C8y C    38.7040  -15.0560
            34  C8x C    37.4917  -14.3558
            35  C6a C    39.9237  -14.3521
            36  O6a O    41.1172  -15.0416
            37  O6a O    39.9240  -12.9502
            38  N1a N    35.8702  -19.1003
            39  C1b C    37.0869  -18.3978
            40  C1b C    38.3036  -19.1003
            41  O1a O    39.5203  -18.3978
BOND        42
            1     5   6 2
            2     6   7 1
            3     7   8 1
            4     8   9 1
            5     5   9 1
            6     8  10 2
            7     9  11 1
            8    11  12 1
            9    13  14 1
            10    7  14 2
            11    6  15 1
            12   11  16 2
            13   16  17 1
            14   17  18 2
            15   18  19 1
            16   12  19 2
            17   13  20 1
            18   19  21 1
            19   18  22 1
            20   20  23 2
            21   23  24 1
            22   24  25 2
            23   25  26 1
            24   26  27 2
            25   20  27 1
            26   23  28 1
            27   24  29 1
            28   29  30 2
            29   30  31 1
            30   31  32 2
            31   32  33 1
            32   33  34 2
            33   29  34 1
            34   33  35 1
            35   35  36 1
            36   35  37 2
            37    1   2 1
            38    2   3 1
            39    3   4 1
            40   38  39 1
            41   39  40 1
            42   40  41 1
BRACKET     1    33.8800  -19.8800   33.8800  -17.6400
            1    40.8100  -17.6400   40.8100  -19.8800
            1  2
 ORIGINAL  1    1   2   3   4
 REPEAT    1   38  39  40  41

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