KEGG   DRUG: D03978Help
Entry
D03978                      Drug                                   

Name
Eltrombopag olamine (JAN/USAN);
Promacta (TN)
Product
Formula
C25H22N4O4. (C2H7NO)2
Exact mass
564.2696
Mol weight
564.6327
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of chemotherapy-induced thrombocytopenia and treatment of immune thrombocytopenic purpura [DS:H01240]
Remark
Therapeutic category: 
ATC code: 
Comment
Use Eltrombopag olamine to patients who have factor V leiden mutation or Antithrombin III deficiency is at risk of increase thromboembolism.
Target
thrombopoietin receptor agonist [HSA:4352] [KO:K05082]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  Jak-STAT signaling pathway  
 
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2C8 [HSA:1558]
Interaction
Genomic biomarker: F5 [HSA:2153], SERPINC1 [HSA:462]
Transporter inhibition: ABCG2 [HSA:9429], SLCO1B1 [HSA:10599]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BX Other systemic hemostatics
     B02BX05 Eltrombopag
      D03978  Eltrombopag olamine (JAN/USAN)
USP drug classification [BR:br08302]
 Blood Products/Modifiers/Volume Expanders
  Blood Formation Modifiers
   Eltrombopag olamine
    D03978  Eltrombopag olamine (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D03978  Eltrombopag olamine (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Class I cytokine receptors (hematopoietin family receptors)
   thrombopoietin receptor
    Eltrombopag
     D03978  Eltrombopag olamine (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Eltrombopag
    D03978  Eltrombopag olamine (JAN/USAN)
  CYP2C8
   Eltrombopag
    D03978  Eltrombopag olamine (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
496775-62-3
PubChem: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        41
            1   N1a N    35.8702  -19.1003
            2   C1b C    37.0869  -18.3978
            3   C1b C    38.3036  -19.1003
            4   O1a O    39.5203  -18.3978
            5   N2x N    27.1600  -16.3800
            6   C2y C    28.5600  -16.3800
            7   C2y C    28.9926  -15.0485
            8   C5x C    27.8600  -14.2256
            9   N1y N    26.7274  -15.0485
            10  O5x O    27.8600  -12.8100
            11  C8y C    25.5149  -14.3485
            12  C8x C    24.3025  -15.0485
            13  N1b N    31.4175  -15.0485
            14  N2b N    30.2051  -14.3485
            15  C1a C    29.3829  -17.5126
            16  C8x C    25.5149  -12.9485
            17  C8x C    24.3025  -12.2485
            18  C8y C    23.0901  -12.9485
            19  C8y C    23.0901  -14.3485
            20  C8y C    32.6299  -14.3485
            21  C1a C    21.8845  -15.0446
            22  C1a C    21.8857  -12.2532
            23  C8y C    33.8355  -15.0446
            24  C8y C    35.0480  -14.3446
            25  C8x C    35.0480  -12.9446
            26  C8x C    33.8424  -12.2485
            27  C8x C    32.6300  -12.9485
            28  O1a O    33.8356  -16.4498
            29  C8y C    36.2792  -15.0556
            30  C8x C    36.2790  -16.4499
            31  C8x C    37.4913  -17.1501
            32  C8x C    38.7038  -16.4502
            33  C8y C    38.7040  -15.0560
            34  C8x C    37.4917  -14.3558
            35  C6a C    39.9237  -14.3521
            36  O6a O    41.1172  -15.0416
            37  O6a O    39.9240  -12.9502
            38  N1a N    35.8702  -19.1003
            39  C1b C    37.0869  -18.3978
            40  C1b C    38.3036  -19.1003
            41  O1a O    39.5203  -18.3978
BOND        42
            1     5   6 2
            2     6   7 1
            3     7   8 1
            4     8   9 1
            5     5   9 1
            6     8  10 2
            7     9  11 1
            8    11  12 1
            9    13  14 1
            10    7  14 2
            11    6  15 1
            12   11  16 2
            13   16  17 1
            14   17  18 2
            15   18  19 1
            16   12  19 2
            17   13  20 1
            18   19  21 1
            19   18  22 1
            20   20  23 2
            21   23  24 1
            22   24  25 2
            23   25  26 1
            24   26  27 2
            25   20  27 1
            26   23  28 1
            27   24  29 1
            28   29  30 2
            29   30  31 1
            30   31  32 2
            31   32  33 1
            32   33  34 2
            33   29  34 1
            34   33  35 1
            35   35  36 1
            36   35  37 2
            37    1   2 1
            38    2   3 1
            39    3   4 1
            40   38  39 1
            41   39  40 1
            42   40  41 1
BRACKET     1    33.8800  -19.8800   33.8800  -17.6400
            1    40.8100  -17.6400   40.8100  -19.8800
            1  2
 ORIGINAL  1    1   2   3   4
 REPEAT    1   38  39  40  41

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