KEGG   DRUG: D04687Help
Entry
D04687                      Drug                                   

Name
Lenalidomide (USAN/INN);
Revlimid (TN)
Product
Formula
C13H13N3O3
Exact mass
259.0957
Mol weight
259.2606
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Immunomulator intended for use in the treatment of multiple myeloma, myelodysplastic syndromes, solid tumors including glioma and metastatic melanoma, Crohn's disease, and heart failure [DS:H00010]
Remark
ATC code: 
Drug group: 
Comment
Thalidomide [DR:D00754] derivative
Indication: Multiple myeloma (MM), Myelodysplastic syndromes (MDS)
Lenalidomide is for the type of MDS with a chromosome problem where part of chromosome 5 is missing.
Target
TNF-alpha inhibitor [HSA:7124] [KO:K03156]
Interaction
Genomic biomarker: Chromosome-5q deletion
Drug interaction
Structure map
Immunosuppressive agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AX Other immunosuppressants
     L04AX04 Lenalidomide
      D04687  Lenalidomide (USAN/INN)
USP drug classification [BR:br08302]
 Antineoplastics
  Antiangiogenic Agents
   Lenalidomide
    D04687  Lenalidomide (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokines
  TNF family
   TNF-alpha
    Lenalidomide
     D04687  Lenalidomide (USAN/INN)
Antineoplastics [BR:br08308]
 Biologic response modifiers
  Nonspecific immunomodulation
   Lenalidomide
    D04687  Lenalidomide (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
191732-72-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        19
            1   C8x C    12.8800  -15.7500
            2   C8x C    12.8800  -17.1500
            3   C8x C    14.0924  -17.8500
            4   C8y C    15.3049  -17.1500
            5   C8y C    15.3049  -15.7500
            6   C8y C    14.0924  -15.0500
            7   C5x C    16.6364  -17.5826
            8   N1y N    17.4593  -16.4500
            9   C1x C    16.6364  -15.3174
            10  C1y C    18.8300  -16.4500
            11  O5x O    17.0675  -18.9094
            12  N1a N    14.0924  -13.6502
            13  C1x C    19.5300  -17.6624
            14  C1x C    20.9300  -17.6624
            15  C5x C    21.6300  -16.4500
            16  N1x N    20.9300  -15.2376
            17  C5x C    19.5300  -15.2376
            18  O5x O    18.8396  -14.0421
            19  O5x O    23.0300  -16.4500
BOND        21
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    5   9 1
            11    8  10 1
            12    7  11 2
            13    6  12 1
            14   10  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   10  17 1
            20   17  18 2
            21   15  19 2

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