KEGG   DRUG: MetforminHelp
Entry
D04966                      Drug                                   

Name
Metformin (USAN/INN)
Formula
C4H11N5
Exact mass
129.1014
Mol weight
129.1636
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Antidiabetic agent
 DG01685  Insulin sensitizer
  DG01684  Biguanide antidiabetic
Unclassified
 DG02044  Hypoglycemics
  DG01684  Biguanide antidiabetic
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antidiabetic, Hypoglycemic, AMP kinase activator
Comment
Component of Actoplus met (TN)
biguanides
Target
AMPK (PRKAA) [HSA:5562 5563] [KO:K07198]
  Pathway
Autophagy - animal
mTOR signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Metabolism
Transporter: SLC22A2 [HSA:6582], SLC22A1 [HSA:6580], SLC47A1 [HSA:55244], SCL47A2 [HSA:146802]
Interaction
Drug interaction
Structure map
Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BA Biguanides
     A10BA02 Metformin
      D04966  Metformin (USAN/INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Metformin
    D04966  Metformin (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine protein kinases: CAMK group
   CAMKL family
    AMPK
     Metformin
      D04966  Metformin (USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Transporter substrates
  SLC22A2
   Metformin
    D04966  Metformin (USAN/INN)
  MATE1
   Metformin
    D04966  Metformin (USAN/INN)
  MATE2
   Metformin
    D04966  Metformin (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
657-24-9
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        9
            1   C2c C    26.2960  -19.4016
            2   N1b N    25.0898  -18.7081
            3   N1c N    27.5139  -18.7081
            4   N2a N    26.2960  -20.8058
            5   C2c C    23.8721  -19.4016
            6   C1a C    28.7260  -19.4016
            7   C1a C    27.5139  -17.3038
            8   N1a N    22.6600  -18.7081
            9   N2a N    23.8721  -20.8058
BOND        8
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     5   8 1
            8     5   9 2

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