KEGG   DRUG: D04966Help
Entry
D04966                      Drug                                   

Name
Metformin (USAN/INN)
Formula
C4H11N5
Exact mass
129.1014
Mol weight
129.1636
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidiabetic [DS:H00409]
Remark
Same as: 
ATC code: 
Comment
Component of Actoplus met (TN)
biguanides
Target
AMPK activator [HSA:5562 5563] [KO:K07198]
  Pathway
hsa04140  Regulation of autophagy
hsa04150  mTOR signaling pathway
hsa04910  Insulin signaling pathway
hsa04920  Adipocytokine signaling pathway  
 
Metabolism
Transporter: SLC22A2 [HSA:6582], SLC22A1 [HSA:6580], SLC47A1 [HSA:55244], SCL47A2 [HSA:146802]
Interaction
Drug interaction
Structure map
Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BA Biguanides
     A10BA02 Metformin
      D04966  Metformin (USAN/INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Metformin
    D04966  Metformin (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine protein kinases: CAMK group
   CAMKL family
    AMPK [HSA:5562 5563] [KO:K07198]
     Metformin [ATC:A10BA02]
      D04966  Metformin (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
657-24-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        9
            1   C2c C    26.2960  -19.4016
            2   N1b N    25.0898  -18.7081
            3   N1c N    27.5139  -18.7081
            4   N2a N    26.2960  -20.8058
            5   C2c C    23.8721  -19.4016
            6   C1a C    28.7260  -19.4016
            7   C1a C    27.5139  -17.3038
            8   N1a N    22.6600  -18.7081
            9   N2a N    23.8721  -20.8058
BOND        8
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     5   8 1
            8     5   9 2

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