KEGG   DRUG: D05008Help
Entry
D05008                      Drug                                   

Name
Metoclopramide hydrochloride (USAN);
Metoclopramide hydrochloride monohydrate;
Clopra (TN);
Reglan (TN)
Product
  Generic
METOCLOPRAMIDE (A-S Medication Solutions LLC), METOCLOPRAMIDE (ANIP Acquisition Company), METOCLOPRAMIDE (Actavis Elizabeth LLC), METOCLOPRAMIDE (Aidarex Pharmaceuticals LLC), METOCLOPRAMIDE (American Health Packaging), METOCLOPRAMIDE (Bryant Ranch Prepack), METOCLOPRAMIDE (Cardinal Health), METOCLOPRAMIDE (Cardinal Health), METOCLOPRAMIDE (Cardinal Health), METOCLOPRAMIDE (Lake Erie Medical DBA Quality Care Products LLC), METOCLOPRAMIDE (Liberty Pharmaceuticals), METOCLOPRAMIDE (McKesson Contract Packager), METOCLOPRAMIDE (Mylan Institutional), METOCLOPRAMIDE (NCS HealthCare of KY), METOCLOPRAMIDE (NCS HealthCare of KY), METOCLOPRAMIDE (NCS HealthCare of KY), METOCLOPRAMIDE (Par Pharmaceutical), METOCLOPRAMIDE (Physicians Total Care), METOCLOPRAMIDE (Preferred Pharmaceuticals), METOCLOPRAMIDE (Preferred Pharmaceuticals), METOCLOPRAMIDE (Qualitest Pharmaceuticals), METOCLOPRAMIDE (REMEDYREPACK), METOCLOPRAMIDE (REMEDYREPACK), METOCLOPRAMIDE (REMEDYREPACK), METOCLOPRAMIDE (REMEDYREPACK), METOCLOPRAMIDE (REMEDYREPACK), METOCLOPRAMIDE (Ranbaxy Pharmaceuticals), METOCLOPRAMIDE (Rebel Distributors Corp.), METOCLOPRAMIDE (State of Florida DOH Central Pharmacy), METOCLOPRAMIDE (Teva Parenteral Medicines), METOCLOPRAMIDE (Teva Pharmaceuticals USA), METOCLOPRAMIDE (UDL Laboratories), METOCLOPRAMIDE (American Health Packaging), METOCLOPRAMIDE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), METOCLOPRAMIDE (BD Rx), METOCLOPRAMIDE HYDROCHLORIDE (Bryant Ranch Prepack), METOCLOPRAMIDE (Cardinal Health), METOCLOPRAMIDE (Cardinal Health), METOCLOPRAMIDE HYDROCHLORIDE (Cardinal Health), METOCLOPRAMIDE (Heritage Pharmaceuticals), METOCLOPRAMIDE (Hospira), METOCLOPRAMIDE (McKesson Contract Packaging), METOCLOPRAMIDE (McKesson Contract Packaging), METOCLOPRAMIDE HYDROCHLORIDE (McKesson Packaging Services a business unit of McKesson Corporation), METOCLOPRAMIDE (Morton Grove Pharmaceuticals), METOCLOPRAMIDE HYDROCHLORIDE (Northstar RxLLC), METOCLOPRAMIDE (Pharmaceutical Associates), METOCLOPRAMIDE (Precision Dose), METOCLOPRAMIDE HYDROCHLORIDE (Preferred Pharmaceuticals), METOCLOPRAMIDE HYDROCHLORIDE (REMEDYREPACK), METOCLOPRAMIDE HYDROCHLORIDE (REMEDYREPACK), METOCLOPRAMIDE HYDROCHLORIDE (Rebel Distributors Corp), METOCLOPRAMIDE HYDROCHLORIDE (Rebel Distributors Corp), METOCLOPRAMIDE (STAT RX USA LLC), METOCLOPRAMIDE HYDROCHLORIDE (State of Florida DOH Central Pharmacy), METOCLOPRAMIDE HYDROCHLORIDE (VistaPharm), METOCLOPRAMIDE HYDROCHLORIDE (Watson Laboratories)
Formula
C14H22ClN3O2. HCl. H2O
Exact mass
353.1273
Mol weight
354.2726
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiemetic
Remark
ATC code: 
Drug group: 
Target
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145];
5-HT4-receptor agonist [HSA:3360] [KO:K04160];
5-HT3-receptor antagonist [HSA:3359 9177 170572 200909 285242] [KO:K04819]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Genomic biomarker: CYB5R [HSA:51706 51700 1727 51167]
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antipsychotics
Antimigraines
Serotonin receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A03 DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
   A03F PROPULSIVES
    A03FA Propulsives
     A03FA01 Metoclopramide
      D05008  Metoclopramide hydrochloride (USAN)
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Metoclopramide
    D05008  Metoclopramide hydrochloride (USAN)
 Gastrointestinal Agents
  Gastrointestinal Agents, Other
   Metoclopramide
    D05008  Metoclopramide hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor
     Metoclopramide
      D05008  Metoclopramide hydrochloride (USAN)
   Serotonin
    5-HT3-receptor
     Metoclopramide
      D05008  Metoclopramide hydrochloride (USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Metoclopramide
    D05008  Metoclopramide hydrochloride (USAN)
 Inhbitors
  CYP2D6
   Metoclopramide
    D05008  Metoclopramide hydrochloride (USAN)
Animal drugs in Japan [BR:br08331]
 93  Agents affecting digestive organs
  932  Antistomach, antidiarrhoics (including absorptives, antidiarrhoics, antibububble and preparations)
   9329  Other antistomach, antidiarrhoics and preparations
    D05008  Metoclopramide hydrochloride
BRITE hierarchy
Other DBs
CAS: 
54143-57-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        22
            1   C8y C    20.4459  -16.5247
            2   C8y C    20.4459  -15.1244
            3   C8x C    19.2556  -17.2249
            4   C5a C    21.7062  -17.2249
            5   C8x C    19.2556  -14.4243
            6   O2a O    21.7062  -14.4243
            7   C8y C    18.0654  -16.5247
            8   N1b N    22.8965  -16.5247
            9   O5a O    21.7062  -18.6252
            10  C8y C    18.0654  -15.1244
            11  C1a C    22.8965  -15.1244
            12  X   Cl   16.8751  -17.2249
            13  C1b C    24.1567  -17.2249
            14  N1a N    16.8751  -14.4243
            15  C1b C    25.3470  -16.5247
            16  N1c N    26.5373  -17.2249
            17  C1b C    27.7976  -16.5247
            18  C1b C    26.5373  -18.6252
            19  C1a C    28.9878  -17.2249
            20  C1a C    27.7976  -19.3254
            21  X   Cl   33.3900  -15.4700
            22  O0  O    33.8100  -17.7800
BOND        20
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 2
            9     5  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 1
            13   10  14 1
            14   13  15 1
            15   15  16 1
            16   16  17 1
            17   16  18 1
            18   17  19 1
            19   18  20 1
            20    7  10 2

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