KEGG   DRUG: D05374Help
Entry
D05374                      Drug                                   

Name
Paroxetine hydrochloride (USP);
Paxil (TN)
Product
  Generic
PAROXETINE (DIRECT RX), PAROXETINE (REMEDYREPACK), PAROXETINE (Apotex Corp.), PAROXETINE (Bryant Ranch Prepack), PAROXETINE (Bryant Ranch Prepack), PAROXETINE (Cadila Healthcare Limited), PAROXETINE (Cardinal Health), PAROXETINE (Cardinal Health), PAROXETINE (Contract Pharmacy Services-PA), PAROXETINE (Major Pharmaceuticals), PAROXETINE (Major Pharmaceuticals), PAROXETINE (MedVantx), PAROXETINE (PD-Rx Pharmaceuticals), PAROXETINE (Physicians Total Care), PAROXETINE (Preferred Pharmaceuticals), PAROXETINE (Preferred Pharmaceuticals), PAROXETINE HYDROCHLORIDE (REMEDYREPACK), PAROXETINE (REMEDYREPACK), PAROXETINE HYDROCHLORIDE (REMEDYREPACK), PAROXETINE (State of Florida DOH Central Pharmacy), PAROXETINE (State of Florida DOH Central Pharmacy), PAROXETINE (Teva Pharmaceuticals USA), PAROXETINE (Unit Dose Services)
Formula
C19H20FNO3. HCl
Exact mass
365.1194
Mol weight
365.8263
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidepressant
Remark
ATC code: 
Drug group: 
Comment
Selective serotonin reuptake inhibitor (SSRI)
Target
serotonin transporter inhibitor [HSA:6532] [KO:K05037]
  Pathway
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Transporter: ABCB1 [HSA:5243]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AB Selective serotonin reuptake inhibitors
     N06AB05 Paroxetine
      D05374  Paroxetine hydrochloride (USP)
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Paroxetine
    D05374  Paroxetine hydrochloride (USP)
 Anxiolytics
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Paroxetine
    D05374  Paroxetine hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (serotonin transporter)
     Paroxetine
      D05374  Paroxetine hydrochloride (USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Paroxetine
    D05374  Paroxetine hydrochloride (USP)
 Inhbitors
  CYP2D6
   Paroxetine
    D05374  Paroxetine hydrochloride (USP)
BRITE hierarchy
Other DBs
CAS: 
78246-49-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        25
            1   C1y C    25.2966  -20.5661
            2   C1y C    24.0856  -21.2622
            3   C8y C    25.3023  -19.1620
            4   C1x C    26.5074  -21.2622
            5   C1b C    22.8746  -20.5661
            6   C1x C    24.0856  -22.6663
            7   C8x C    26.5133  -18.4659
            8   C8x C    24.0913  -18.4659
            9   C1x C    26.5074  -22.6663
            10  O2a O    21.6576  -21.2622
            11  N1x N    25.2966  -23.3626
            12  C8x C    26.5133  -17.0677
            13  C8x C    24.0913  -17.0619
            14  C8y C    20.4465  -20.5601
            15  C8y C    25.3023  -16.3657
            16  C8x C    20.4525  -19.1679
            17  C8x C    19.2415  -21.2681
            18  X   F    25.2381  -14.9675
            19  C8y C    19.2472  -18.4659
            20  C8x C    18.0305  -20.5661
            21  C8y C    18.0305  -19.1679
            22  O2x O    18.9607  -17.0911
            23  O2x O    16.9891  -18.2260
            24  C1x C    17.5624  -16.9391
            25  X   Cl   29.5912  -22.1540
BOND        27
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1 #Up
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 2
            13   10  14 1
            14   12  15 2
            15   14  16 2
            16   14  17 1
            17   15  18 1
            18   16  19 1
            19   17  20 2
            20   19  21 2
            21   19  22 1
            22   21  23 1
            23   22  24 1
            24    9  11 1
            25   13  15 1
            26   20  21 1
            27   23  24 1

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