KEGG   DRUG: D05375Help
Entry
D05375                      Drug                                   

Name
Paroxetine mesylate (USAN);
Brisdelle (TN);
Pexeva (TN)
Product
Formula
C19H20FNO3. CH4SO3
Exact mass
425.1308
Mol weight
425.4711
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of major depressive disorder, obsessive compulsive disorder, and panic disorder [selective serotonin reuptake inhibitor]
Remark
ATC code: 
Drug group: 
Comment
Selective serotonin reuptake inhibitor (SSRI)
Target
serotonin transporter inhibitor [HSA:6532] [KO:K05037]
  Pathway
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Transporter: ABCB1 [HSA:5243]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AB Selective serotonin reuptake inhibitors
     N06AB05 Paroxetine
      D05375  Paroxetine mesylate (USAN)
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Paroxetine
    D05375  Paroxetine mesylate (USAN)
 Anxiolytics
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Paroxetine
    D05375  Paroxetine mesylate (USAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (serotonin transporter)
     Paroxetine
      D05375  Paroxetine mesylate (USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Paroxetine
    D05375  Paroxetine mesylate (USAN)
 Inhbitors
  CYP2D6
   Paroxetine
    D05375  Paroxetine mesylate (USAN)
BRITE hierarchy
Other DBs
CAS: 
217797-14-3
PubChem: 
DrugBank: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        29
            1   C1y C    10.4825   -8.1745
            2   C1y C     9.2690   -8.8721
            3   C8y C    10.4883   -6.8611
            4   C1x C    11.6958   -8.8721
            5   C1b C     8.0556   -8.1745
            6   C1x C     9.2690  -10.2791
            7   C8x C    11.7018   -6.1634
            8   C8x C     9.2748   -6.1634
            9   C1x C    11.6958  -10.2791
            10  O2a O     6.8361   -8.8721
            11  N1x N    10.4825  -10.9766
            12  C8x C    11.7018   -4.7624
            13  C8x C     9.2748   -4.7566
            14  C8y C     5.6226   -8.1686
            15  C8y C    10.4883   -4.0589
            16  C8x C     5.6286   -6.7733
            17  C8x C     4.4151   -8.8781
            18  X   F    10.4942   -2.7982
            19  C8y C     4.4208   -6.0699
            20  C8x C     3.2016   -8.1745
            21  C8y C     3.2016   -6.7733
            22  O2x O     4.1337   -4.6456
            23  O2x O     2.2048   -5.7829
            24  C1x C     2.6857   -4.3996
            25  O1d O    15.9383   -6.5271
            26  S4a S    15.9383   -7.9217
            27  C1a C    14.5438   -7.9217
            28  O1d O    17.3329   -7.9217
            29  O1d O    15.9383   -9.3162
BOND        31
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1 #Up
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 2
            13   10  14 1
            14   12  15 2
            15   14  16 2
            16   14  17 1
            17   15  18 1
            18   16  19 1
            19   17  20 2
            20   19  21 2
            21   19  22 1
            22   21  23 1
            23   22  24 1
            24    9  11 1
            25   13  15 1
            26   20  21 1
            27   23  24 1
            28   25  26 2
            29   26  27 1
            30   26  28 1
            31   26  29 2

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