KEGG   DRUG: Paroxetine mesylateHelp
Entry
D05375                      Drug                                   

Name
Paroxetine mesylate (USAN);
Brisdelle (TN);
Pexeva (TN)
Product
Formula
C19H20FNO3. CH4SO3
Exact mass
425.1308
Mol weight
425.4711
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01659  Selective serotonin reuptake inhibitor
Cyp substrate
 DG01644  CYP2D6 substrate
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
Transporter substrate
 DG01665  P-glycoprotein substrate
Remark
ATC code: 
Chemical group: 
Activity
Antidepressant, SSRI
Comment
Selective serotonin reuptake inhibitor (SSRI)
Fluoxetine derivative
Treatment of major depressive disorder, obsessive compulsive disorder, and panic disorder
Target
serotonin transporter [HSA:6532] [KO:K05037]
  Pathway
Serotonergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Transporter: ABCB1 [HSA:5243]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AB Selective serotonin reuptake inhibitors
     N06AB05 Paroxetine
      D05375  Paroxetine mesylate (USAN)
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Paroxetine
    D05375  Paroxetine mesylate (USAN)
 Anxiolytics
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Paroxetine
    D05375  Paroxetine mesylate (USAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (serotonin transporter)
     Paroxetine
      D05375  Paroxetine mesylate (USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2D6
   Paroxetine
    D05375  Paroxetine mesylate (USAN)
 CYP substrates
  CYP2D6
   Paroxetine
    D05375  Paroxetine mesylate (USAN)
 Transporter substrates
  ABCB1
   Paroxetine
    D05375  Paroxetine mesylate (USAN)
Psychiatric agents [br08363.html]
 Antidepressants
  D05375
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D05375
BRITE hierarchy
Other DBs
CAS: 
217797-14-3
PubChem: 
DrugBank: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        29
            1   C1y C    10.4825   -8.1745
            2   C1y C     9.2690   -8.8721
            3   C8y C    10.4883   -6.8611
            4   C1x C    11.6958   -8.8721
            5   C1b C     8.0556   -8.1745
            6   C1x C     9.2690  -10.2791
            7   C8x C    11.7018   -6.1634
            8   C8x C     9.2748   -6.1634
            9   C1x C    11.6958  -10.2791
            10  O2a O     6.8361   -8.8721
            11  N1x N    10.4825  -10.9766
            12  C8x C    11.7018   -4.7624
            13  C8x C     9.2748   -4.7566
            14  C8y C     5.6226   -8.1686
            15  C8y C    10.4883   -4.0589
            16  C8x C     5.6286   -6.7733
            17  C8x C     4.4151   -8.8781
            18  X   F    10.4942   -2.7982
            19  C8y C     4.4208   -6.0699
            20  C8x C     3.2016   -8.1745
            21  C8y C     3.2016   -6.7733
            22  O2x O     4.1337   -4.6456
            23  O2x O     2.2048   -5.7829
            24  C1x C     2.6857   -4.3996
            25  O1d O    15.9383   -6.5271
            26  S4a S    15.9383   -7.9217
            27  C1a C    14.5438   -7.9217
            28  O1d O    17.3329   -7.9217
            29  O1d O    15.9383   -9.3162
BOND        31
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1 #Up
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 2
            13   10  14 1
            14   12  15 2
            15   14  16 2
            16   14  17 1
            17   15  18 1
            18   16  19 1
            19   17  20 2
            20   19  21 2
            21   19  22 1
            22   21  23 1
            23   22  24 1
            24    9  11 1
            25   13  15 1
            26   20  21 1
            27   23  24 1
            28   25  26 2
            29   26  27 1
            30   26  28 1
            31   26  29 2

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