KEGG   DRUG: Pazopanib hydrochlorideHelp
Entry
D05380                      Drug                                   

Name
Pazopanib hydrochloride (JAN/USAN);
Votrient (TN)
Product
Formula
C21H23N7O2S. HCl
Exact mass
473.1401
Mol weight
473.979
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
 DG01522  CYP3A4 inhibitor
Transporter substrate
 DG01913  BCRP substrate
Remark
Therapeutic category: 
ATC code: 
Activity
Antineoplastic, Tyrosine kinase inhibitor
  Disease
Malignant soft tissue sarcoma [DS:H00046 H00037 H00041 H00050 H00051 H00052 H00053]
Target
PDGFRA tyrosine kinase inhibitor [HSA:5156] [KO:K04363];
PDGFRB tyrosine kinase inhibitor [HSA:5159] [KO:K05089];
VEGFR1 tyrosine kinase inhibitor [HSA:2321] [KO:K05096];
VEGFR2 tyrosine kinase inhibitor [HSA:3791] [KO:K05098];
VEGFR3 tyrosine kinase inhibitor [HSA:2324] [KO:K05097];
c-KIT tyrosine kinase inhibitor [HSA:3815] [KO:K05091]
  Pathway
MAPK signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
Pathways in cancer
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP1A2 [HSA:1544], CYP2C8 [HSA:1558]
Transporter: ABCB1 [HSA:5243], ABCG2 [HSA:9429]
Interaction
Genomic biomarker: UGT1A1 [HSA:54658]
CYP inhibition: CYP2D6 [HSA:1565], CYP3A [HSA:1576 1577 1551]
Drug interaction
Structure map
Antineoplastics - protein kinases inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XE Protein kinase inhibitors
     L01XE11 Pazopanib
      D05380  Pazopanib hydrochloride (JAN/USAN)
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Pazopanib
    D05380  Pazopanib hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D05380  Pazopanib hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    PDGFRA tyrosine kinase
     Pazopanib
      D05380  Pazopanib hydrochloride (JAN/USAN)
    PDGFRB tyrosine kinase
     Pazopanib
      D05380  Pazopanib hydrochloride (JAN/USAN)
    c-KIT tyrosine kinase
     Pazopanib
      D05380  Pazopanib hydrochloride (JAN/USAN)
   RTK class V (VEGF receptor family)
    VEGFR1 tyrosine kinase
     Pazopanib
      D05380  Pazopanib hydrochloride (JAN/USAN)
    VEGFR2 tyrosine kinase
     Pazopanib
      D05380  Pazopanib hydrochloride (JAN/USAN)
    VEGFR3 tyrosine kinase
     Pazopanib
      D05380  Pazopanib hydrochloride (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2D6
   Pazopanib
    D05380  Pazopanib hydrochloride (JAN/USAN)
  CYP3A
   Pazopanib
    D05380  Pazopanib hydrochloride (JAN/USAN)
Antineoplastics [br08340.html]
 D05380
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D05380
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D05380
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D05380
BRITE hierarchy
Other DBs
CAS: 
635702-64-6
PubChem: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        32
            1   C8x C     8.1900  -18.2000
            2   C8y C     8.1900  -19.6000
            3   C8y C     9.4024  -20.3000
            4   C8x C    10.6149  -19.6000
            5   C8y C    10.6149  -18.2000
            6   C8x C     9.4024  -17.5000
            7   N5x N    13.0397  -19.6000
            8   C8y C    13.0397  -18.2000
            9   N1b N    11.8273  -17.5000
            10  C8x C    14.2522  -20.3000
            11  C8x C    15.4646  -19.6000
            12  C8y C    15.4646  -18.2000
            13  N5x N    14.2522  -17.5000
            14  N1c N    16.6811  -17.4977
            15  C8y C    17.8786  -18.1892
            16  C1a C    16.6811  -16.1002
            17  C1a C     6.9776  -20.3000
            18  S4a S     9.4024  -21.6998
            19  N1a N     9.4024  -23.0998
            20  O3c O     7.9800  -21.6998
            21  O3c O    10.7800  -21.6998
            22  C8x C    17.8787  -19.5997
            23  C8x C    19.0911  -20.2996
            24  C8y C    20.3035  -19.5996
            25  C8y C    20.3035  -18.1891
            26  C8x C    19.0910  -17.4892
            27  C8y C    21.6450  -20.0354
            28  N4y N    22.4741  -18.8942
            29  N5x N    21.6449  -17.7532
            30  C1a C    23.8700  -18.8942
            31  C1a C    22.0716  -21.3485
            32  X   Cl   22.1900  -23.9400
BOND        34
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15   12  14 1
            16   14  15 1
            17   14  16 1
            18    2  17 1
            19    3  18 1
            20   18  19 1
            21   18  20 2
            22   18  21 2
            23   15  22 1
            24   22  23 2
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   15  26 2
            29   24  27 2
            30   27  28 1
            31   28  29 1
            32   25  29 2
            33   28  30 1
            34   27  31 1

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