KEGG   DRUG: Prasugrel hydrochlorideHelp
Entry
D05597                      Drug                                   

Name
Prasugrel hydrochloride (JAN/USAN);
Effient (TN)
Product
Formula
C20H20FNO3S. HCl
Exact mass
409.0915
Mol weight
409.902
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01712  Antiplatelet agent
 DG01809  P2Y12 receptor antagonist
  DG01808  Thienopyridine
Remark
Therapeutic category: 
ATC code: 
Activity
Inhibits platelet aggregation [platelet ADPP 2Y12 antagonist]
Target
P2Y12 receptor antagonist [HSA:64805] [KO:K04298]
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551], CYP2B6 [HSA:1555]
Interaction
Genomic biomarker: CYP2C19 [HSA:1557]
CYP inhibition: CYP2B6 [HSA:1555]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AC Platelet aggregation inhibitors excl. heparin
     B01AC22 Prasugrel
      D05597  Prasugrel hydrochloride (JAN/USAN)
USP drug classification [BR:br08302]
 Blood Products/Modifiers/Volume Expanders
  Platelet Modifying Agents
   Prasugrel
    D05597  Prasugrel hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   339  Miscellaneous
    3399  Others
     D05597  Prasugrel hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Purine / pyrimidine
    P2Y12 receptor
     Prasugrel
      D05597  Prasugrel hydrochloride (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2B6
   Prasugrel
    D05597  Prasugrel hydrochloride (JAN/USAN)
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D05597
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D05597
BRITE hierarchy
Other DBs
CAS: 
389574-19-0
PubChem: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        27
            1   N1y N    17.0100  -15.7500
            2   C1x C    17.0100  -14.3500
            3   C1x C    18.2000  -13.6500
            4   C8y C    19.4600  -14.3500
            5   C8y C    19.4600  -15.7500
            6   C1x C    18.2000  -16.4500
            7   S2x S    20.7900  -13.9300
            8   C8y C    21.5600  -15.0500
            9   C8x C    20.7900  -16.1700
            10  O7a O    22.9600  -15.0500
            11  C7a C    23.6600  -13.8600
            12  C1a C    25.0600  -13.8600
            13  O6a O    22.9600  -12.6700
            14  C1c C    15.8200  -16.4500
            15  C8y C    14.6300  -15.7500
            16  C5a C    15.8200  -17.8500
            17  O5a O    17.0100  -18.5500
            18  C1y C    14.6300  -18.5500
            19  C8y C    14.6300  -14.3500
            20  C8x C    13.3700  -13.6500
            21  C8x C    12.1800  -14.3500
            22  C8x C    12.1800  -15.7500
            23  C8x C    13.3700  -16.4500
            24  C1x C    13.2300  -18.5500
            25  C1x C    13.9300  -19.7400
            26  X   F    15.8200  -13.6500
            27  X   Cl   24.7800  -18.0600
BOND        29
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    5   9 1
            11    8  10 1
            12   10  11 1
            13   11  12 1
            14   11  13 2
            15    1  14 1
            16   14  15 1
            17   14  16 1
            18   16  17 2
            19   16  18 1
            20   15  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   15  23 1
            26   18  24 1
            27   24  25 1
            28   25  18 1
            29   19  26 1

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