KEGG   DRUG: D05597Help
Entry
D05597                      Drug                                   

Name
Prasugrel hydrochloride (JAN/USAN);
Effient (TN)
Product
Formula
C20H20FNO3S. HCl
Exact mass
409.0915
Mol weight
409.902
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Inhibits platelet aggregation [platelet ADPP 2Y12 antagonist]
Remark
Therapeutic category: 
ATC code: 
Target
P2Y12 receptor antagonist [HSA:64805] [KO:K04298]
Interaction
Genomic biomarker: CYP2C19 [HSA:1557]
CYP inhibition: CYP2B6 [HSA:1555]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AC Platelet aggregation inhibitors excl. heparin
     B01AC22 Prasugrel
      D05597  Prasugrel hydrochloride (JAN/USAN)
USP drug classification [BR:br08302]
 Blood Products/Modifiers/Volume Expanders
  Platelet Modifying Agents
   Prasugrel
    D05597  Prasugrel hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   339  Miscellaneous
    3399  Others
     D05597  Prasugrel hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Purine / pyrimidine
    P2Y12 receptor
     Prasugrel
      D05597  Prasugrel hydrochloride (USAN)
Cytochrome P450 interactions [BR:br08309]
 Inhbitors
  CYP2B6
   Prasugrel
    D05597  Prasugrel hydrochloride (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
389574-19-0
PubChem: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        27
            1   N1y N    17.0100  -15.7500
            2   C1x C    17.0100  -14.3500
            3   C1x C    18.2000  -13.6500
            4   C8y C    19.4600  -14.3500
            5   C8y C    19.4600  -15.7500
            6   C1x C    18.2000  -16.4500
            7   S2x S    20.7900  -13.9300
            8   C8y C    21.5600  -15.0500
            9   C8x C    20.7900  -16.1700
            10  O7a O    22.9600  -15.0500
            11  C7a C    23.6600  -13.8600
            12  C1a C    25.0600  -13.8600
            13  O6a O    22.9600  -12.6700
            14  C1c C    15.8200  -16.4500
            15  C8y C    14.6300  -15.7500
            16  C5a C    15.8200  -17.8500
            17  O5a O    17.0100  -18.5500
            18  C1y C    14.6300  -18.5500
            19  C8y C    14.6300  -14.3500
            20  C8x C    13.3700  -13.6500
            21  C8x C    12.1800  -14.3500
            22  C8x C    12.1800  -15.7500
            23  C8x C    13.3700  -16.4500
            24  C1x C    13.2300  -18.5500
            25  C1x C    13.9300  -19.7400
            26  X   F    15.8200  -13.6500
            27  X   Cl   24.7800  -18.0600
BOND        29
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    5   9 1
            11    8  10 1
            12   10  11 1
            13   11  12 1
            14   11  13 2
            15    1  14 1
            16   14  15 1
            17   14  16 1
            18   16  17 2
            19   16  18 1
            20   15  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   15  23 1
            26   18  24 1
            27   24  25 1
            28   25  18 1
            29   19  26 1

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