KEGG   DRUG: RetapamulinHelp
Entry
D05720                      Drug                                   

Name
Retapamulin (USAN/INN);
Altabax (TN)
Product
Formula
C30H47NO4S
Exact mass
517.3226
Mol weight
517.7635
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antibacterial
 DG01813  Pleuromutilin
Remark
ATC code: 
Efficacy
Antibiotic, Protein biosynthesis inhibitor
Comment
Pleuromutilin [CPD:C09169] derivative
Topical antibiotic for secondarily infected traumatic lesions (SITL) and secondarily infected dermatoses (SID) or impetigo
Target
50S ribosomal subunit
  Pathway
Ribosome
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AX Other antibiotics for topical use
     D06AX13 Retapamulin
      D05720  Retapamulin (USAN/INN)
USP drug classification [BR:br08302]
 Antibacterials
  Antibacterials, Other
   Retapamulin
    D05720  Retapamulin (USAN/INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   50S subunit inhibitor
    Pleuromutilin derivatives
     Retapamulin
      D05720  Retapamulin (USAN/INN)
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from ornithine
   Tropane alkaloids
    D05720  Retapamulin (USAN/INN)
Antibacterials [br08350.html]
 D05720
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D05720
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D05720
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D05720
BRITE hierarchy
Other DBs
CAS: 
224452-66-8
PubChem: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        36
            1   C1x C    21.3514  -20.9923
            2   C1y C    19.9657  -20.0223
            3   C1y C    19.8964  -20.9923
            4   N1y N    19.1342  -19.1908
            5   C1x C    18.9957  -20.6459
            6   C1x C    18.4414  -21.7545
            7   C1a C    19.1342  -17.8051
            8   C1x C    21.3514  -20.0223
            9   C1y C    22.2522  -21.5466
            10  S2a S    23.3608  -22.5166
            11  C1b C    24.7465  -22.5166
            12  C7a C    25.4394  -21.2002
            13  O6a O    24.6772  -20.0223
            14  C1z C    31.4259  -20.7270
            15  C1y C    30.4496  -21.7090
            16  C1y C    31.4259  -19.3350
            17  C1x C    32.6680  -21.3625
            18  C1x C    31.4200  -22.1076
            19  C1z C    29.0576  -21.7090
            20  C5x C    31.0735  -22.9512
            21  C1y C    30.4496  -18.3530
            22  C1a C    32.7083  -18.8033
            23  C1x C    32.4483  -22.7373
            24  C1x C    30.1021  -22.1415
            25  C1y C    28.0756  -20.7212
            26  C1y C    29.0517  -23.0955
            27  C1a C    28.1776  -22.7826
            28  O5x O    30.4439  -24.1872
            29  C1z C    29.0576  -18.3530
            30  O1a O    30.9753  -17.0704
            31  C1x C    28.0756  -19.3350
            32  O7a O    26.7873  -21.1885
            33  C1a C    28.6821  -24.4357
            34  C2b C    28.5373  -17.0966
            35  C1a C    27.6703  -18.3530
            36  C2a C    28.5373  -15.7094
BOND        40
            1     8   2 1
            2     8   9 1
            3     1   3 1
            4     2   4 1
            5     2   5 1
            6     3   6 1
            7     3   4 1
            8     5   6 1
            9     4   7 1
            10    9   1 1
            11    9  10 1
            12   10  11 1
            13   11  12 1
            14   12  13 2
            15   16  21 1
            16   16  22 1 #Down
            17   17  23 1
            18   18  24 1
            19   19  25 1
            20   19  26 1
            21   19  27 1 #Up
            22   20  28 2
            23   21  29 1
            24   21  30 1 #Up
            25   25  31 1
            26   25  32 1 #Down
            27   26  33 1 #Up
            28   20  23 1
            29   24  26 1
            30   29  31 1
            31   14  15 1
            32   14  16 1
            33   14  17 1
            34   14  18 1 #Up
            35   15  19 1
            36   15  20 1
            37   29  34 1 #Up
            38   29  35 1 #Down
            39   34  36 2
            40   12  32 1

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