KEGG   DRUG: RufinamideHelp
Entry
D05775                      Drug                                   

Name
Rufinamide (JAN/USAN/INN);
Banzel (TN)
Product
Formula
C10H8F2N4O
Exact mass
238.0666
Mol weight
238.1935
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG02034  Carboxamide antiepileptics
Cyp inducer
 DG01635  CYP3A4 inducer
 DG01897  CYP3A5 inducer
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Efficacy
Antiepileptic
Comment
Carboxamide derivative
Rufinamide is a weak inhibitor of CYP 2E1.
Rufinamide is a weak inducer of CYP3A4 enzymes.
Target
SCN1A [HSA:6323] [KO:K04833];
SCN2A [HSA:6326] [KO:K04834];
SCN3A [HSA:6328] [KO:K04836];
SCN4A [HSA:6329] [KO:K04837];
SCN5A [HSA:6331] [KO:K04838];
SCN8A [HSA:6334] [KO:K04840];
SCN9A [HSA:6335] [KO:K04841];
SCN10A [HSA:6336] [KO:K04842];
SCN11A [HSA:11280] [KO:K04843]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AF Carboxamide derivatives
     N03AF03 Rufinamide
      D05775  Rufinamide (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Anticonvulsants
  Sodium Channel Agents
   Rufinamide
    D05775  Rufinamide (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D05775  Rufinamide (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Rufinamide
      D05775  Rufinamide (JAN/USAN/INN)
    voltage-gated sodium channel (SCN2A)
     Rufinamide
      D05775  Rufinamide (JAN/USAN/INN)
    voltage-gated sodium channel (SCN3A)
     Rufinamide
      D05775  Rufinamide (JAN/USAN/INN)
    voltage-gated sodium channel (SCN4A)
     Rufinamide
      D05775  Rufinamide (JAN/USAN/INN)
    voltage-gated sodium channel (SCN5A)
     Rufinamide
      D05775  Rufinamide (JAN/USAN/INN)
    voltage-gated sodium channel (SCN8A)
     Rufinamide
      D05775  Rufinamide (JAN/USAN/INN)
    voltage-gated sodium channel (SCN9A)
     Rufinamide
      D05775  Rufinamide (JAN/USAN/INN)
    voltage-gated sodium channel (SCN10A)
     Rufinamide
      D05775  Rufinamide (JAN/USAN/INN)
    voltage-gated sodium channel (SCN11A)
     Rufinamide
      D05775  Rufinamide (JAN/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inducers
  CYP3A
   Rufinamide
    D05775  Rufinamide (JAN/USAN/INN)
Neurological agents [br08367.html]
 Antiepileptic agents
  D05775
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D05775
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D05775
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D05775
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D05775
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D05775
BRITE hierarchy
Other DBs
CAS: 
106308-44-5
PubChem: 
ChEMBL: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        17
            1   C8x C    27.5379  -17.1661
            2   C8x C    27.5379  -18.5624
            3   C8x C    28.7471  -19.2605
            4   C8y C    29.9564  -18.5624
            5   C8y C    29.9564  -17.1661
            6   C8y C    28.7471  -16.4679
            7   X   F    28.7471  -15.0718
            8   X   F    31.1843  -19.2715
            9   C1b C    31.1843  -16.4570
            10  N4y N    32.3863  -17.1508
            11  N5x N    32.4321  -18.5562
            12  N5x N    33.7844  -18.9475
            13  C8y C    34.5745  -17.7822
            14  C8x C    33.7104  -16.6707
            15  C5a C    35.9312  -17.8076
            16  N1a N    36.5583  -19.0940
            17  O5a O    36.6991  -16.6707
BOND        18
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     4   8 1
            9     5   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15   10  14 1
            16   13  15 1
            17   15  16 1
            18   15  17 2

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