KEGG   DRUG: Sodium phenylbutyrateHelp
Entry
D05868                      Drug                                   

Name
Sodium phenylbutyrate (JAN/USAN);
Buphenyl (TN)
Product
  Generic
Formula
C10H11O2. Na
Exact mass
186.0657
Mol weight
186.1829
Structure
Mol fileKCF fileDB searchJmolKegDraw
Remark
Therapeutic category: 
ATC code: 
Activity
Antihyperammonemic
  Disease
Urea cycle disorder
Comment
Active form of prodrug: Phenylacetate [CPD:C07086]
Interaction
Genomic biomarker: NAGS [HSA:162417], CPS [HSA:1373], ASS [HSA:445], OTC [HSA:5009], ASL [HSA:435], ARG [HSA:383 384]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AX Various alimentary tract and metabolism products
     A16AX03 Sodium phenylbutyrate
      D05868  Sodium phenylbutyrate (JAN/USAN)
USP drug classification [BR:br08302]
 Enzyme Replacement/Modifiers
  Sodium phenylbutyrate
   D05868  Sodium phenylbutyrate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D05868  Sodium phenylbutyrate (JAN/USAN)
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D05868
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D05868
BRITE hierarchy
Other DBs
CAS: 
1716-12-7
PubChem: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        13
            1   Z   Na   13.8833  -28.3419 #+
            2   C8x C     8.1900  -28.3500
            3   C8x C     8.1900  -29.7500
            4   C8x C     9.4024  -30.4500
            5   C8x C    10.6149  -29.7500
            6   C8x C    10.6149  -28.3500
            7   C8y C     9.4024  -27.6500
            8   C1b C     9.4024  -26.2502
            9   C1b C    10.5980  -25.5598
            10  C1b C    11.7852  -26.2452
            11  C6a C    12.9766  -25.5572
            12  O6a O    14.1659  -26.2439 #-
            13  O6a O    12.9767  -24.1503
BOND        12
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     7   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12   11  13 2

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