KEGG   DRUG: Testosterone undecanoateHelp
Entry
D06087                      Drug                                   

Name
Testosterone undecanoate (USAN);
Andriol (TN)
Product
Formula
C30H48O3
Exact mass
456.3603
Mol weight
456.7003
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Other
 DG01590  Androgen receptor agonist
Cyp substrate
 DG01633  CYP3A4 substrate
Remark
ATC code: 
Chemical group: 
Activity
In males: testosterone replacement therapy for primary or secondary hypogonadal disorders.
In female-to-male transsexuales: masculinization.
Moreover, in men, testosterone therapy may be indicated in osteoporosis caused by androgen deficiency
Target
NR3C4 (AR) [HSA:367] [KO:K08557]
Metabolism
Enzyme: CYP2B6 [HSA:1555], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
Drug interaction
Structure map
Progesterone, androgen and estrogen receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03B ANDROGENS
    G03BA 3-oxoandrosten (4) derivatives
     G03BA03 Testosterone
      D06087  Testosterone undecanoate (USAN)
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Androgens
   Testosterone
    D06087  Testosterone undecanoate (USAN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    androgen receptor
     Testosterone
      D06087  Testosterone undecanoate (USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP3A4
   Testosterone
    D06087  Testosterone undecanoate (USAN)
  CYP3A5
   Testosterone
    D06087  Testosterone undecanoate (USAN)
  CYP3A7
   Testosterone
    D06087  Testosterone undecanoate (USAN)
 Transporter inhibitors
  SLC22A2
   Testosterone
    D06087  Testosterone undecanoate (USAN)
Endocrine and hormonal agents [br08373.html]
 Hormone related agents
  D06087
BRITE hierarchy
Other DBs
CAS: 
5949-44-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        33
            1   C1y C    27.8027  -26.8341
            2   C1y C    26.6157  -26.1733
            3   C1y C    29.0304  -26.1617
            4   C1x C    27.8085  -28.1907
            5   C1z C    25.4521  -26.8516
            6   C1x C    26.6099  -24.8227
            7   C1z C    29.0190  -24.8168
            8   C1x C    31.3285  -26.1617
            9   C1x C    26.6331  -28.8864
            10  C2y C    25.4695  -28.2082
            11  C1x C    24.2824  -26.1850
            12  C1a C    25.4461  -25.5067
            13  C1x C    27.7793  -24.1444
            14  C1y C    30.1298  -24.1210
            15  C1a C    29.0072  -23.4017
            16  C1x C    31.3111  -24.8051
            17  C2x C    24.2942  -28.8981
            18  C1x C    23.1073  -26.8633
            19  O7a O    30.1241  -22.7060
            20  C5x C    23.1132  -28.2199
            21  O5x O    21.9028  -28.9216
            22  C7a C    31.3241  -22.0068
            23  C1b C    32.5383  -22.7015
            24  O6a O    31.3185  -20.6170
            25  C1b C    33.7162  -22.0153
            26  C1b C    34.9228  -22.7060
            27  C1b C    36.1045  -22.0176
            28  C1b C    37.3324  -22.7500
            29  C1b C    38.5449  -22.0500
            30  C1b C    39.7573  -22.7500
            31  C1b C    40.9697  -22.0500
            32  C1b C    42.1822  -22.7500
            33  C1a C    43.3946  -22.0500
BOND        36
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    5  11 1
            11    5  12 1 #Up
            12    6  13 1
            13    7  14 1
            14    7  15 1 #Up
            15    8  16 1
            16   10  17 2
            17   11  18 1
            18   14  19 1 #Up
            19   17  20 1
            20   20  21 2
            21    7  13 1
            22    9  10 1
            23   14  16 1
            24   18  20 1
            25   19  22 1
            26   22  24 2
            27   26  27 1
            28   22  23 1
            29   23  25 1
            30   25  26 1
            31   27  28 1
            32   28  29 1
            33   29  30 1
            34   30  31 1
            35   31  32 1
            36   32  33 1

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