KEGG   DRUG: FluphenazineHelp
Entry
D07977                      Drug                                   

Name
Fluphenazine (INN);
Moditen (TN)
Formula
C22H26F3N3OS
Exact mass
437.1749
Mol weight
437.5216
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01905  Phenothiazine antipsychotics
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
Cyp substrate
 DG01644  CYP2D6 substrate
Remark
Same as: 
ATC code: 
Chemical group: 
Efficacy
Antipsychotic, Neuroleptic, Dopamine D2 receptor antagonist
Comment
Phenothiazine derivative
Target
  Pathway
Neuroactive ligand-receptor interaction
Gap junction
Interaction
Drug interaction
Structure map
Antipsychotics - phenothiazines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AB Phenothiazines with piperazine structure
     N05AB02 Fluphenazine
      D07977  Fluphenazine (INN)
USP drug classification [BR:br08302]
 Antipsychotics
  1st Generation/Typical
   Fluphenazine
    D07977  Fluphenazine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor
     Fluphenazine
      D07977  Fluphenazine (INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2D6
   Fluphenazine
    D07977  Fluphenazine (INN)
BRITE hierarchy
Other DBs
CAS: 
69-23-8
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        30
            1   C8y C    20.5100  -20.3700
            2   N1y N    21.7000  -19.6700
            3   C8y C    20.5100  -21.7700
            4   C8x C    19.2500  -19.6700
            5   C8y C    22.8900  -20.4400
            6   C1b C    21.7000  -18.2700
            7   S2x S    21.7000  -22.4700
            8   C8x C    19.2500  -22.4700
            9   C8x C    18.0600  -20.4400
            10  C8y C    22.8900  -21.7700
            11  C8x C    24.1500  -19.7400
            12  C1b C    22.8900  -17.5700
            13  C8x C    18.0600  -21.7700
            14  C8x C    24.1500  -22.4700
            15  C8y C    25.3400  -20.4400
            16  C1b C    22.8900  -16.1700
            17  C8x C    25.3400  -21.7700
            18  N1y N    24.1500  -15.4700
            19  C1x C    24.0800  -14.0700
            20  C1x C    25.3400  -16.1700
            21  C1x C    25.3400  -13.3700
            22  C1x C    26.6000  -15.4700
            23  N1y N    26.6000  -14.0700
            24  C1b C    27.8600  -13.4400
            25  C1b C    29.0500  -14.1400
            26  O1a O    30.3100  -13.4400
            27  C1d C    26.6000  -19.7400
            28  X   F    27.7200  -18.9700
            29  X   F    27.2300  -20.8600
            30  X   F    25.8300  -18.4800
BOND        33
            1    18  19 1
            2    18  20 1
            3    19  21 1
            4    20  22 1
            5    21  23 1
            6    23  24 1
            7     7  10 1
            8     9  13 1
            9    15  17 1
            10   22  23 1
            11    1   2 1
            12    1   3 2
            13    1   4 1
            14    2   5 1
            15    2   6 1
            16    3   7 1
            17    3   8 1
            18    4   9 2
            19    5  10 2
            20    5  11 1
            21    6  12 1
            22    8  13 2
            23   10  14 1
            24   11  15 2
            25   12  16 1
            26   14  17 2
            27   16  18 1
            28   24  25 1
            29   25  26 1
            30   15  27 1
            31   27  28 1
            32   27  29 1
            33   27  30 1

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